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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2013

01-03-2013 | Gastrointestinal Oncology

Adenocarcinoma of the Esophagogastric Junction: Territory of the Esophagus or Stomach, or an Independent Region?

Authors: Hiroya Takeuchi, MD, PhD, Yuko Kitagawa, MD, PhD, FACS

Published in: Annals of Surgical Oncology | Issue 3/2013

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Excerpt

The most recent union for international cancer control (UICC) tumor-node-metastasis (TNM) classification (7th edition) definitively classified adenocarcinoma of the esophagogastric junction (AEG) for the first time.1 A tumor whose epicenter is within 5 cm of the esophagogastric junction (EGJ) and also extends into the esophagus is classified and staged according to the esophageal cancer scheme. All other gastric tumors with an epicenter greater than 5 cm from EGJ or within 5 cm of EGJ without extension into the esophagus are staged using the gastric cancer scheme. Therefore, most AEGs, including adenocarcinomas of the cardia and subcardia, are now to be staged as esophageal adenocarcinomas rather than gastric cancers by the current edition of TNM classification. …
Literature
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UICC. Oesophagus including oesophagogastric junction. In: Sobin LH, Gospodarowicz M, Wittekind C, editors. TNM classification of malignant tumours. 7th ed. New York: Wiley; 2009. p. 66–72.
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Siewert JR, Stein HJ. Classification of adenocarcinoma of the oesophagogastric junction. Br J Surg. 1998;85:1457–9.PubMedCrossRef
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Gertler R, Stein HJ, Loos M, Langer R, Friess H, Feith M. How to classify adenocarcinomas of the esophagogastric junction: as esophageal or gastric cancer? Am J Surg Pathol. 2011;10:1512–22.CrossRef
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Huang Q, Shi J, Feng A, Fan X, Zhang L, Mashimo H, et al. Gastric cardiac carcinomas involving the esophagus are more adequately staged as gastric cancers by the 7th edition of the American Joint Commission on Cancer Staging System. Mod Pathol. 2011;24:138–46.PubMedCrossRef
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Hasegawa S, Yoshikawa T, Aoyama T, et al. Esophagus or stomach? The seventh TNM classification for Siewert type II/III junctional adenocarcinoma. Ann Surg Oncol. 2012. doi:10.​1245/​s10434-012-2780-x.
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Omloo JM, Lagarde SM, Hulscher JB, Reitsma JB, Fockens P, van Dekken H, et al. Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the mid/distal esophagus: five-year survival of a randomized clinical trial. Ann Surg. 2007;246:992–1001.PubMedCrossRef
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Sasako M, Sano T, Yamamoto S, Sairenji M, Arai K, Kinoshita T, et al. Left thoracoabdominal approach versus abdominal-transhiatal approach for gastric cancer of the cardia or subcardia: a randomised controlled trial. Lancet Oncol. 2006;7:644–51.PubMedCrossRef
Metadata
Title
Adenocarcinoma of the Esophagogastric Junction: Territory of the Esophagus or Stomach, or an Independent Region?
Authors
Hiroya Takeuchi, MD, PhD
Yuko Kitagawa, MD, PhD, FACS
Publication date
01-03-2013
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 3/2013
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-012-2781-9

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