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01-03-2013 | Head and Neck Oncology

Utility of ¹⁸F-FDG PET/CT for Detecting Neck Metastasis in Patients with Salivary Gland Carcinomas: Preoperative Planning for Necessity and Extent of Neck Dissection

Authors: Min-Joo Kim, MD, Jae Seung Kim, MD, Jong-Lyel Roh, MD, Jeong Hyun Lee, MD, Kyung-Ja Cho, MD, Seung-Ho Choi, MD, Soon Yuhl Nam, MD, Sang Yoon Kim, MD

Published in: Annals of Surgical Oncology | Issue 3/2013

Abstract

Background:

The precise diagnosis of cervical lymph node metastasis (CLNM) of salivary gland cancer is important to determine the surgical extent and adjuvant therapy. This study assessed the clinical utility of ¹⁸F-FDG PET in identifying CLNM in such patients.

Methods:

Fifty-four patients with intermediate or high-grade salivary gland cancer were preoperatively evaluated with ¹⁸F-FDG PET/CT and CT/MRI. Histopathologic analysis of neck dissection tissues was used as the gold standard for assessing imaging techniques. Tumor and nodal maximum standardized uptake values (SUVmax) were measured for each patient. Univariate and multivariate analyses were used to identify CLNM predictive factors.

Results:

Of the 54 patients, 24 patients (44 %) had CLNM. On a per-patient basis, the sensitivity and specificity of ¹⁸F-FDG PET/CT and CT/MRI were not significantly different (92 vs. 83 %, P = 0.625 and 93 vs. 97 %, P = 1.000, respectively). On a per-level basis, ¹⁸F-FDG PET/CT was significantly more sensitive and accurate than CT/MRI in the ipsilateral neck (96 vs. 54 %, P < 0.001 and 92 vs. 83 %, P < 0.001, respectively). The mean nodal SUVmax values of patients with and without nodal metastasis were 4.9 and 2.1, respectively (P = 0.008). Histologic grade was a significant predictor of CLNM (P = 0.014, odds ratio 14.46, 95 % confidence interval 1.73–120.79).

Conclusions:

¹⁸F-FDG PET/CT imaging and histologic grade are useful for detecting CLNM in patients with salivary gland carcinoma. This finding may guide preoperative planning for the necessity and extent of neck dissection in these patients.

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Title: Utility of 18F-FDG PET/CT for Detecting Neck Metastasis in Patients with Salivary Gland Carcinomas: Preoperative Planning for Necessity and Extent of Neck Dissection
Authors: Min-Joo Kim, MD
Jae Seung Kim, MD
Jong-Lyel Roh, MD
Jeong Hyun Lee, MD
Kyung-Ja Cho, MD
Seung-Ho Choi, MD
Soon Yuhl Nam, MD
Sang Yoon Kim, MD
Publication date: 01-03-2013
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 3/2013
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-012-2716-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Utility of ¹⁸F-FDG PET/CT for Detecting Neck Metastasis in Patients with Salivary Gland Carcinomas: Preoperative Planning for Necessity and Extent of Neck Dissection

Abstract

Background:

Methods:

Results:

Conclusions:

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background:

Methods:

Results:

Conclusions:

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