Skip to main content
Top
Published in: BMC Medicine 1/2024

Open Access 01-12-2024 | Addiction | Research article

The effectiveness of a standardized tobacco cessation program on psychophysiological parameters in patients with addiction undergoing long-term rehabilitation: a quasi-experimental pilot study

Authors: J. Fuchshuber, H. Schöber, M. Wohlmuth, H. Senra, C. Rominger, A. Schwerdtfeger, H. F. Unterrainer

Published in: BMC Medicine | Issue 1/2024

Login to get access

Abstract

Background

Although there is a very high comorbidity between tobacco dependence and other addictive disorders, there are only few studies examining the implementation and outcomes of a tobacco cessation program in patients with addictive diseases. Therefore, the aim of this study is to investigate to what extent a standardized tobacco cessation program leads to improvements regarding psychological/physical parameters in patients with addiction undergoing therapy and whether there is a reduction in tobacco consumption.

Methods

The study took place in a therapeutic community specialized in addiction therapy. A total sample of 56 participants were non-randomly assigned to an intervention group (IG; n = 31) and a treatment as usual group (TAUG; n = 25). The IG participated in a 6-week tobacco cessation program, while the TAUG received no additional treatment. Both groups were assessed for changes in primary outcomes (tobacco dependence, smoked cigarettes per day (CPD), and general substance-related craving) and secondary outcomes (heart rate variability (HRV): root mean square of successive differences, self-efficacy, and comorbid psychiatric symptoms) at two measurement time points (pre- and post-treatment/6 weeks).

Results

We observed significant improvements in self-efficacy (F(1,53) = 5.86; p < .05; ηp2 = .11) and decreased CPD in the IG (β = 1.16, ρ < .05), while no significant changes were observed in the TAUG. No significant interaction effects were observed in psychiatric symptoms, general substance-related craving, and HRV.

Conclusions

The results highlight the potential benefit of an additional tobacco cessation program as part of a general addiction treatment. Although no improvements in the physiological domain were observed, there were significant improvements regarding self-efficacy and CPD in the IG compared to the TAUG. Randomized controlled trials on larger samples would be an important next step.

Trial registration

ISRCTN15684371
Literature
1.
go back to reference Preston SH, Glei DA, Wilmoth JR. A new method for estimating smoking-attributable mortality in high-income countries. Int J Epidemiol. 2010;39(2):430–8.PubMedCrossRef Preston SH, Glei DA, Wilmoth JR. A new method for estimating smoking-attributable mortality in high-income countries. Int J Epidemiol. 2010;39(2):430–8.PubMedCrossRef
2.
go back to reference Anzenberger J, Busch M, Klein C, Priebe B, Schmutterer I, Strizek J. Epidemiologiebericht Sucht 2022. Illegale Drogen, Alkohol und Tabak. Wien: Gesundheit Österreich; 2022. Anzenberger J, Busch M, Klein C, Priebe B, Schmutterer I, Strizek J. Epidemiologiebericht Sucht 2022. Illegale Drogen, Alkohol und Tabak. Wien: Gesundheit Österreich; 2022.
3.
go back to reference Guydish J, Passalacqua E, Tajima B, Chan M, Chun J, Bostrom A. Smoking prevalence in addiction treatment: a review. Nicotine Tob Res. 2011;13(6):401–11.PubMedPubMedCentralCrossRef Guydish J, Passalacqua E, Tajima B, Chan M, Chun J, Bostrom A. Smoking prevalence in addiction treatment: a review. Nicotine Tob Res. 2011;13(6):401–11.PubMedPubMedCentralCrossRef
4.
go back to reference Parker MA, Sigmon SC, Villanti AC. Higher smoking prevalence among United States adults with co-occurring affective and drug use diagnoses. Addict Behav. 2019;99:106112.PubMedPubMedCentralCrossRef Parker MA, Sigmon SC, Villanti AC. Higher smoking prevalence among United States adults with co-occurring affective and drug use diagnoses. Addict Behav. 2019;99:106112.PubMedPubMedCentralCrossRef
5.
go back to reference Farrell M, Howes S, Bebbington P, Brugha T, Jenkins R, Lewis G, Marsden J, Taylor C, Meltzer H. Nicotine, alcohol and drug dependence, and psychiatric comorbidity–results of a national household survey. Int Rev Psychiatry. 2003;15(1–2):50–6.PubMedCrossRef Farrell M, Howes S, Bebbington P, Brugha T, Jenkins R, Lewis G, Marsden J, Taylor C, Meltzer H. Nicotine, alcohol and drug dependence, and psychiatric comorbidity–results of a national household survey. Int Rev Psychiatry. 2003;15(1–2):50–6.PubMedCrossRef
6.
go back to reference Balbuena L, Peters E, Speed D. Using polygenic risk scores to investigate the evolution of smoking and mental health outcomes in UK biobank participants. Acta Psychiatr Scand. 2023;148(5):447–56.PubMedCrossRef Balbuena L, Peters E, Speed D. Using polygenic risk scores to investigate the evolution of smoking and mental health outcomes in UK biobank participants. Acta Psychiatr Scand. 2023;148(5):447–56.PubMedCrossRef
7.
go back to reference Mühlig S. Tabakentwöhnung bei Patienten mit psychiatrischer Störung. Suchttherapie. 2009;10(01):914. Mühlig S. Tabakentwöhnung bei Patienten mit psychiatrischer Störung. Suchttherapie. 2009;10(01):914.
8.
go back to reference McKelvey K, Thrul J, Ramo D. Impact of quitting smoking and smoking cessation treatment on substance use outcomes: an updated and narrative review. Addict Behav. 2017;65:161–70.PubMedCrossRef McKelvey K, Thrul J, Ramo D. Impact of quitting smoking and smoking cessation treatment on substance use outcomes: an updated and narrative review. Addict Behav. 2017;65:161–70.PubMedCrossRef
9.
go back to reference Prochaska JJ, Hall SM, Tsoh JY, Eisendrath S, Rossi JS, Redding CA, Rosen AB, Meisner M, Humfleet GL, Gorecki JA. Treating tobacco dependence in clinically depressed smokers: effect of smoking cessation on mental health functioning. Am J Public Health. 2008;98(3):446–8.PubMedPubMedCentralCrossRef Prochaska JJ, Hall SM, Tsoh JY, Eisendrath S, Rossi JS, Redding CA, Rosen AB, Meisner M, Humfleet GL, Gorecki JA. Treating tobacco dependence in clinically depressed smokers: effect of smoking cessation on mental health functioning. Am J Public Health. 2008;98(3):446–8.PubMedPubMedCentralCrossRef
10.
go back to reference Stage KB, Glassman AH, Covey LS. Depression after smoking cessation. J Clin Psychiatry. 1996;57(10):467–9.PubMedCrossRef Stage KB, Glassman AH, Covey LS. Depression after smoking cessation. J Clin Psychiatry. 1996;57(10):467–9.PubMedCrossRef
11.
go back to reference Caldwell PE, Cutter HS. Alcoholics Anonymous affiliation during early recovery. J Subst Abuse Treat. 1998;15(3):221–8.PubMedCrossRef Caldwell PE, Cutter HS. Alcoholics Anonymous affiliation during early recovery. J Subst Abuse Treat. 1998;15(3):221–8.PubMedCrossRef
12.
go back to reference Laudet AB, Morgen K, White WL. The role of social supports, spirituality, religiousness, life meaning and affiliation with 12-step fellowships in quality of life satisfaction among individuals in recovery from alcohol and drug problems. Alcohol Treat Q. 2006;24(1–2):33–73.PubMedPubMedCentralCrossRef Laudet AB, Morgen K, White WL. The role of social supports, spirituality, religiousness, life meaning and affiliation with 12-step fellowships in quality of life satisfaction among individuals in recovery from alcohol and drug problems. Alcohol Treat Q. 2006;24(1–2):33–73.PubMedPubMedCentralCrossRef
13.
go back to reference Cookson C, Strang J, Ratschen E, Sutherland G, Finch E, McNeill A. Smoking and its treatment in addiction services: clients’ and staff behaviour and attitudes. BMC Health Serv Res. 2014;14:1–8.CrossRef Cookson C, Strang J, Ratschen E, Sutherland G, Finch E, McNeill A. Smoking and its treatment in addiction services: clients’ and staff behaviour and attitudes. BMC Health Serv Res. 2014;14:1–8.CrossRef
14.
go back to reference Ziedonis DM, Guydish J, Williams J, Steinberg M, Foulds J. Barriers and solutions to addressing tobacco dependence in addiction treatment programs. Alcohol Res Health. 2006;29(3):228.PubMedPubMedCentral Ziedonis DM, Guydish J, Williams J, Steinberg M, Foulds J. Barriers and solutions to addressing tobacco dependence in addiction treatment programs. Alcohol Res Health. 2006;29(3):228.PubMedPubMedCentral
15.
go back to reference Fu SS, Kodl M, Willenbring M, Nelson DB, Nugent S, Gravely AA, Joseph AM. Ethnic differences in alcohol treatment outcomes and the effect of concurrent smoking cessation treatment. Drug Alcohol Depend. 2008;92(1–3):61–8.PubMedCrossRef Fu SS, Kodl M, Willenbring M, Nelson DB, Nugent S, Gravely AA, Joseph AM. Ethnic differences in alcohol treatment outcomes and the effect of concurrent smoking cessation treatment. Drug Alcohol Depend. 2008;92(1–3):61–8.PubMedCrossRef
16.
go back to reference Gwaltney CJ, Metrik J, Kahler CW, Shiffman S. Self-efficacy and smoking cessation: a meta-analysis. Psychol Addict Behav. 2009;23(1):56.PubMedCrossRef Gwaltney CJ, Metrik J, Kahler CW, Shiffman S. Self-efficacy and smoking cessation: a meta-analysis. Psychol Addict Behav. 2009;23(1):56.PubMedCrossRef
17.
go back to reference De Leon G, Unterrainer HF. The therapeutic community: A unique social psychological approach to the treatment of addictions and related disorders. Front Psychiatry. 2020;11:494340. De Leon G, Unterrainer HF. The therapeutic community: A unique social psychological approach to the treatment of addictions and related disorders. Front Psychiatry. 2020;11:494340.
18.
go back to reference Chun J, Haug NA, Guydish JR, Sorensen JL, Delucchi K. Cigarette smoking among opioid-dependent clients in a therapeutic community. Am J Addict. 2009;18(4):316–20.PubMedPubMedCentralCrossRef Chun J, Haug NA, Guydish JR, Sorensen JL, Delucchi K. Cigarette smoking among opioid-dependent clients in a therapeutic community. Am J Addict. 2009;18(4):316–20.PubMedPubMedCentralCrossRef
19.
go back to reference Moon SJE, Schlenk EA, Lee H. Heart rate variability in adults with substance use disorder: a comprehensive narrative review. J Am Psychiatr Nurses Assoc. (2024;30(2):240–51. Moon SJE, Schlenk EA, Lee H. Heart rate variability in adults with substance use disorder: a comprehensive narrative review. J Am Psychiatr Nurses Assoc. (2024;30(2):240–51.
20.
go back to reference Cheng Y-C, Huang Y-C, Huang W-L. Heart rate variability as a potential biomarker for alcohol use disorders: a systematic review and meta-analysis. Drug Alcohol Depend. 2019;204:107502.PubMedCrossRef Cheng Y-C, Huang Y-C, Huang W-L. Heart rate variability as a potential biomarker for alcohol use disorders: a systematic review and meta-analysis. Drug Alcohol Depend. 2019;204:107502.PubMedCrossRef
21.
go back to reference Dinas PC, Koutedakis Y, Flouris AD. Effects of active and passive tobacco cigarette smoking on heart rate variability. Int J Cardiol. 2013;163(2):109–15.PubMedCrossRef Dinas PC, Koutedakis Y, Flouris AD. Effects of active and passive tobacco cigarette smoking on heart rate variability. Int J Cardiol. 2013;163(2):109–15.PubMedCrossRef
22.
go back to reference van Ravenswaaij-Arts CM, Kollee LA, Hopman JC, Stoelinga GB, van Geijn HP. Heart rate variability. Ann Intern Med. 1993;118(6):436–47.PubMedCrossRef van Ravenswaaij-Arts CM, Kollee LA, Hopman JC, Stoelinga GB, van Geijn HP. Heart rate variability. Ann Intern Med. 1993;118(6):436–47.PubMedCrossRef
24.
go back to reference Rajendra Acharya U, Paul Joseph K, Kannathal N, Lim CM, Suri JS. Heart rate variability: a review. Med Biol Eng Comput. 2006;44:1031–51.PubMedCrossRef Rajendra Acharya U, Paul Joseph K, Kannathal N, Lim CM, Suri JS. Heart rate variability: a review. Med Biol Eng Comput. 2006;44:1031–51.PubMedCrossRef
25.
go back to reference Harte CB, Meston CM. Effects of smoking cessation on heart rate variability among long-term male smokers. Int J Behav Med. 2014;21:302–9.PubMedCrossRef Harte CB, Meston CM. Effects of smoking cessation on heart rate variability among long-term male smokers. Int J Behav Med. 2014;21:302–9.PubMedCrossRef
26.
go back to reference Stein PK, Rottman JN, Kleiger RE. Effect of 21 mg transdermal nicotine patches and smoking cessation on heart rate variability. Am J Cardiol. 1996;77(9):701–5.PubMedCrossRef Stein PK, Rottman JN, Kleiger RE. Effect of 21 mg transdermal nicotine patches and smoking cessation on heart rate variability. Am J Cardiol. 1996;77(9):701–5.PubMedCrossRef
27.
go back to reference Minami J, Ishimitsu T, Matsuoka H. Effects of smoking cessation on blood pressure and heart rate variability in habitual smokers. Hypertension. 1999;33(1):586–90.PubMedCrossRef Minami J, Ishimitsu T, Matsuoka H. Effects of smoking cessation on blood pressure and heart rate variability in habitual smokers. Hypertension. 1999;33(1):586–90.PubMedCrossRef
28.
go back to reference Yotsukura M, Koide Y, Fujii K, Tomono Y, Katayama A, Ando H, Suzuki J, Ishikawa K. Heart rate variability during the first month of smoking cessation. Am Heart J. 1998;135(6):1004–9.PubMedCrossRef Yotsukura M, Koide Y, Fujii K, Tomono Y, Katayama A, Ando H, Suzuki J, Ishikawa K. Heart rate variability during the first month of smoking cessation. Am Heart J. 1998;135(6):1004–9.PubMedCrossRef
29.
go back to reference Dilling H, Mombour W, Schmidt M.H. Internationale Klassifikation psychischer Störungen ICD-10, Kapitel V (F): Klinisch-diagnostische Leitlinien [International Classification of Diseases ICD-10]. Bern: Verlag Hans Huber; 2005. Dilling H, Mombour W, Schmidt M.H. Internationale Klassifikation psychischer Störungen ICD-10, Kapitel V (F): Klinisch-diagnostische Leitlinien [International Classification of Diseases ICD-10]. Bern: Verlag Hans Huber; 2005.
30.
go back to reference Batra A, Buchkremer G. Nichtrauchen!: Erfolgreich aussteigen in sechs Schritten. Stuttgart: Stuttgart Kohlhammer Verlag; 2017. Batra A, Buchkremer G. Nichtrauchen!: Erfolgreich aussteigen in sechs Schritten. Stuttgart: Stuttgart Kohlhammer Verlag; 2017.
33.
go back to reference Derogatis LR. Brief symptom inventory 18. Baltimore: Johns Hopkins University Baltimore; 2001. Derogatis LR. Brief symptom inventory 18. Baltimore: Johns Hopkins University Baltimore; 2001.
34.
go back to reference Heatherton TF, Kozlowski LT, Frecker RC, Fagerstrom KO. The Fagerström test for nicotine dependence: a revision of the Fagerstrom Tolerance Questionnaire. Br J Addict. 1991;86(9):1119–27.PubMedCrossRef Heatherton TF, Kozlowski LT, Frecker RC, Fagerstrom KO. The Fagerström test for nicotine dependence: a revision of the Fagerstrom Tolerance Questionnaire. Br J Addict. 1991;86(9):1119–27.PubMedCrossRef
35.
go back to reference Fagerström K. Determinants of tobacco use and renaming the FTND to the Fagerström Test for Cigarette Dependence. Nicotine Tob Res. 2011;14(1):75–8.PubMedCrossRef Fagerström K. Determinants of tobacco use and renaming the FTND to the Fagerström Test for Cigarette Dependence. Nicotine Tob Res. 2011;14(1):75–8.PubMedCrossRef
36.
go back to reference Pomerleau CS, Carton SM, Lutzke ML, Flessland KA, Pomerleau OF. Reliability of the Fagerstrom tolerance questionnaire and the Fagerstrom test for nicotine dependence. Addict Behav. 1994;19(1):33–9.PubMedCrossRef Pomerleau CS, Carton SM, Lutzke ML, Flessland KA, Pomerleau OF. Reliability of the Fagerstrom tolerance questionnaire and the Fagerstrom test for nicotine dependence. Addict Behav. 1994;19(1):33–9.PubMedCrossRef
37.
go back to reference Nakovics H, Diehl A, Geiselhart H, Mann K. Development and validation of an overall instrument to measure craving across multiple substances: the Mannheimer Craving Scale (MaCS). Psychiatr Prax. 2008;36(2):72–8.PubMedCrossRef Nakovics H, Diehl A, Geiselhart H, Mann K. Development and validation of an overall instrument to measure craving across multiple substances: the Mannheimer Craving Scale (MaCS). Psychiatr Prax. 2008;36(2):72–8.PubMedCrossRef
38.
go back to reference Schwarzer R, Jerusalem M. Skalen zur Erfassung von Lehrer- und Schülermerkmalen. Dokumentation der psychometrischen Verfahren im Rahmen der Wissenschaftlichen Begleitung des Modellversuchs Selbstwirksame Schulen. Berlin: Freie Universität Berlin; 1999. Schwarzer R, Jerusalem M. Skalen zur Erfassung von Lehrer- und Schülermerkmalen. Dokumentation der psychometrischen Verfahren im Rahmen der Wissenschaftlichen Begleitung des Modellversuchs Selbstwirksame Schulen. Berlin: Freie Universität Berlin; 1999.
39.
go back to reference Tarvainen MP, Lipponen J, Niskanen JP, Ranta-aho PO. Kubios HRV software user’s guide version 3.5. Kubios Oy. 2021.. Tarvainen MP, Lipponen J, Niskanen JP, Ranta-aho PO. Kubios HRV software user’s guide version 3.5. Kubios Oy. 2021..
40.
go back to reference Sztajzel J. Heart rate variability: a noninvasive electrocardiographic method to measure the autonomic nervous system. Swiss Med Wkly. 2004;134(3536):514–22.PubMed Sztajzel J. Heart rate variability: a noninvasive electrocardiographic method to measure the autonomic nervous system. Swiss Med Wkly. 2004;134(3536):514–22.PubMed
41.
go back to reference Shaffer F, Ginsberg JP. An overview of heart rate variability metrics and norms. Front Public Health. 2017;5:290215.CrossRef Shaffer F, Ginsberg JP. An overview of heart rate variability metrics and norms. Front Public Health. 2017;5:290215.CrossRef
42.
43.
go back to reference Munoz ML, Van Roon A, Riese H, Thio C, Oostenbroek E, Westrik I, de Geus EJ, Gansevoort R, Lefrandt J, Nolte IM. Validity of (ultra-) short recordings for heart rate variability measurements. PLoS One. 2015;10(9):e0138921.PubMedPubMedCentralCrossRef Munoz ML, Van Roon A, Riese H, Thio C, Oostenbroek E, Westrik I, de Geus EJ, Gansevoort R, Lefrandt J, Nolte IM. Validity of (ultra-) short recordings for heart rate variability measurements. PLoS One. 2015;10(9):e0138921.PubMedPubMedCentralCrossRef
45.
go back to reference Munafò MR, Nosek BA, Bishop DV, Button KS, Chambers CD. Percie du Sert N, Simonsohn U, Wagenmakers E-J, Ware JJ, Ioannidis J: A manifesto for reproducible science. Nat Hum Behav. 2017;1(1):1–9.CrossRef Munafò MR, Nosek BA, Bishop DV, Button KS, Chambers CD. Percie du Sert N, Simonsohn U, Wagenmakers E-J, Ware JJ, Ioannidis J: A manifesto for reproducible science. Nat Hum Behav. 2017;1(1):1–9.CrossRef
46.
go back to reference Richter KP, McCool RM, Okuyemi KS, Mayo MS, Ahluwalia JS. Patients’ views on smoking cessation and tobacco harm reduction during drug treatment. Nicotine Tob Res. 2002;4(Suppl_2):S175–82.PubMedCrossRef Richter KP, McCool RM, Okuyemi KS, Mayo MS, Ahluwalia JS. Patients’ views on smoking cessation and tobacco harm reduction during drug treatment. Nicotine Tob Res. 2002;4(Suppl_2):S175–82.PubMedCrossRef
47.
go back to reference Black N, Eisma MC, Viechtbauer W, Johnston M, West R, Hartmann-Boyce J, Michie S, de Bruin M. Variability and effectiveness of comparator group interventions in smoking cessation trials: a systematic review and meta-analysis. Addiction. 2020;115(9):1607–17.PubMedPubMedCentralCrossRef Black N, Eisma MC, Viechtbauer W, Johnston M, West R, Hartmann-Boyce J, Michie S, de Bruin M. Variability and effectiveness of comparator group interventions in smoking cessation trials: a systematic review and meta-analysis. Addiction. 2020;115(9):1607–17.PubMedPubMedCentralCrossRef
48.
49.
go back to reference Malivert M, Fatséas M, Denis C, Langlois E, Auriacombe M. Effectiveness of therapeutic communities: a systematic review. Eur Addict Res. 2011;18(1):1–11.PubMedCrossRef Malivert M, Fatséas M, Denis C, Langlois E, Auriacombe M. Effectiveness of therapeutic communities: a systematic review. Eur Addict Res. 2011;18(1):1–11.PubMedCrossRef
50.
go back to reference Vanderplasschen W, Colpaert K, Autrique M, Rapp RC, Pearce S, Broekaert E, Vandevelde S. Therapeutic communities for addictions: a review of their effectiveness from a recovery-oriented perspective. ScientificWorldJournal. 2013;2013:427817.PubMedPubMedCentralCrossRef Vanderplasschen W, Colpaert K, Autrique M, Rapp RC, Pearce S, Broekaert E, Vandevelde S. Therapeutic communities for addictions: a review of their effectiveness from a recovery-oriented perspective. ScientificWorldJournal. 2013;2013:427817.PubMedPubMedCentralCrossRef
Metadata
Title
The effectiveness of a standardized tobacco cessation program on psychophysiological parameters in patients with addiction undergoing long-term rehabilitation: a quasi-experimental pilot study
Authors
J. Fuchshuber
H. Schöber
M. Wohlmuth
H. Senra
C. Rominger
A. Schwerdtfeger
H. F. Unterrainer
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2024
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-024-03405-z

Other articles of this Issue 1/2024

BMC Medicine 1/2024 Go to the issue