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Critical Care
Published in: Critical Care 1/2021

Open Access 01-12-2021 | Acute Respiratory Distress-Syndrome | Research

Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support

Authors: Jonathan Rilinger, Klara Krötzsch, Xavier Bemtgen, Markus Jäckel, Viviane Zotzmann, Corinna N. Lang, Klaus Kaier, Daniel Duerschmied, Alexander Supady, Christoph Bode, Dawid L. Staudacher, Tobias Wengenmayer

Published in: Critical Care | Issue 1/2021

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Abstract

Background

There is limited information about the long-term outcome of patients suffering from acute respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (VV ECMO). Most studies focused on short- to mid-term follow-up. We aimed to investigate long-term survival and health-related quality of life (HRQL) in these patients.

Methods

We report retrospective data from a single-centre registry of patients with severe ARDS treated with VV ECMO at the Interdisciplinary Medical Intensive Care Unit at the Medical Centre, University of Freiburg, Germany, between 10/2010 and 06/2019. Follow-up data of all patients that survived the index hospitalisation were collected by telephone interviews from 02/2020 till 09/2020. Long-term survival, HRQL (Short-Form Health Survey-36 (SF-36), St. Georges Respiratory Questionnaire (SGRQ), Hospital Anxiety and Depression Scale (HADS)) and the return to work rate were documented.

Results

In total, 289 patients were treated with VV ECMO during the study period (median age 55 years, 67% males, hospital survival 45%). After a median duration of 3.9 years, follow-up assessment was complete in 94 of 129 hospital survivors (73%). Fifty-three patients completed the HRQL assessment. Hospital survivors showed a high 6- and 12-month survival rate (89% and 85%, respectively). Estimated survival rate of those discharged alive from ICU was 68.5% (95%-CI 56.9–80.1%) after 9.7 years. These patients reported high levels of HRQL (median SF-36 total score 73) and only few pulmonary (median SGRQ total score 19) and mental limitations (median HAD-D score 2 and HAD-A score 3). In total, 80% of the patients were able to resume employment.

Conclusion

This analysis of VV ECMO patients showed favourable long-term survival and high levels of HRQL suggesting promising prospects for VV ECMO survivors.

Graphical Abstract

Appendix
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Metadata
Title
Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support
Authors
Jonathan Rilinger
Klara Krötzsch
Xavier Bemtgen
Markus Jäckel
Viviane Zotzmann
Corinna N. Lang
Klaus Kaier
Daniel Duerschmied
Alexander Supady
Christoph Bode
Dawid L. Staudacher
Tobias Wengenmayer
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2021
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-021-03821-0

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