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01-12-2021 | Acute Respiratory Distress-Syndrome | Original Article

Selenium-Containing Compound Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Regulating the MAPK/AP-1 Pathway

Authors: Wenjing Jia, Wenting Ding, Xinmiao Chen, Zhengwei Xu, Yelin Tang, Meihong Wang, Bin Zheng, Yali Zhang, Tao Wei, Zaisheng Zhu

Published in: Inflammation | Issue 6/2021

Abstract

Abstract—Acute lung injury (ALI) is characterized by a series of inflammatory reactions and serves as the main cause of mortality in intensive care unit patients. Although great progress has been made in understanding the pathophysiology of ALI, there are no effective treatments in clinic. Recently, we have synthesized a selenium-containing compound, which possesses obvious anti-inflammatory activity. The aim of the present study is to evaluate the protective effects of the selenium-containing compound 34# in LPS-induced ALI in mice as well as its underlying mechanism. Compound 34# was found to inhibit LPS-induced macrophage inflammatory cytokine release. These effects were observed to be produced via suppression of the MAPK/AP-1 pathway. Compound 34# was also noted to attenuate the LPS-induced lung inflammation in mice with ALI. The corresponding results suggested that compound 34# possesses remarkable protective effects on LPS-induced ALI. Furthermore, the MAPK/AP-1 pathway may prove to be the underlying mechanism. Accordingly, compound 34# may serve as a potential candidate for the prevention of ALI.

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Title: Selenium-Containing Compound Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Regulating the MAPK/AP-1 Pathway
Authors: Wenjing Jia
Wenting Ding
Xinmiao Chen
Zhengwei Xu
Yelin Tang
Meihong Wang
Bin Zheng
Yali Zhang
Tao Wei
Zaisheng Zhu
Publication date: 01-12-2021
Publisher: Springer US
Keywords: Acute Respiratory Distress-Syndrome
Cytokines
Published in: Inflammation / Issue 6/2021
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-021-01521-z

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