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Inflammation
Published in: Inflammation 6/2021

01-12-2021 | Acute Respiratory Distress-Syndrome | Original Article

Ameliorative Effects of Oleuropein on Lipopolysaccharide-Induced Acute Lung Injury Model in Rats

Authors: Nursel Dikmen, Mustafa Cellat, Muhammed Etyemez, Cafer Tayer İşler, Ahmet Uyar, Tuba Aydın, Mehmet Güvenç

Published in: Inflammation | Issue 6/2021

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Abstract

Acute lung injury (ALI) is one of the most common causes of death in diseases with septic shock. Oleuropein, one of the important components of olive leaf, has antioxidant and anti-inflammatory effects. The objective of this study was to investigate the effects of oleuropein on lipopolysaccharide (LPS)-induced ALI in rats. Oleuropein was administered to rats at a dose of 200 mg/kg for 20 days and LPS was given through intratracheal administration to induce ALI. The study was terminated after 12 h. The results showed that in the group treated with oleuropein, inflammatory cytokines and oxidative stress decreased in serum, bronchoalveolar lavage fluid (BALF), and lung tissue, and there were significant improvements in the picture of acute interstitial pneumonia (AIP) caused by LPS in histopathological examination. Based on the findings of the present study, oleuropein showed protective effects against LPS-induced ALI.
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Metadata
Title
Ameliorative Effects of Oleuropein on Lipopolysaccharide-Induced Acute Lung Injury Model in Rats
Authors
Nursel Dikmen
Mustafa Cellat
Muhammed Etyemez
Cafer Tayer İşler
Ahmet Uyar
Tuba Aydın
Mehmet Güvenç
Publication date
01-12-2021
Publisher
Springer US
Published in
Inflammation / Issue 6/2021
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-021-01496-x

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