Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Environmental Health and Preventive Medicine
Published in: Environmental Health and Preventive Medicine 1/2021

Open Access 01-12-2021 | Acute Lymphoblastic Leukemia | Research article

The CEBPE rs2239633 genetic polymorphism on susceptibility to childhood acute lymphoblastic leukemia: an updated meta-analysis

Authors: Jin Liu, Gu Weiling, Li Xueqin, Xie Liang, Wang Linhong, Chen Zhongwen

Published in: Environmental Health and Preventive Medicine | Issue 1/2021

Login to get access

Abstract

Objectives

We performed an updated meta-analysis to clarify the relationship between the CEBPE rs2239633 polymorphism and the childhood acute lymphoblastic leukemia (CALL) susceptibility.

Methods

All the case-control studies were updated on October 5, 2020, through Web of Science, PubMed, Cochrane Library, Embase, and China National Knowledge Infrastructure (CNKI) electronic database. The heterogeneity in the study was tested by the Q test and I2, and then the random ratio or fixed effect was utilized to merge the odds ratios (OR) and 95% confidence interval (CI). We also performed sensitivity analysis to estimate the impact of individual studies on aggregate estimates. Publication bias was investigated by using funnel plot and Egger’s regression test. All statistical analyses were performed using Stata 12.0.

Results

A total of 20 case-control studies were selected, including 7014 patients and 16,428 controls. There was no association of CEBPE rs2239633 polymorphism with CALL (CC vs CT + TT: OR = 1.08, 95% CI = 0.94–1.26; CC + CT vs TT: OR = 1.10, 95% CI = 0.94–1.30; C vs T: OR = 1.02, 95% CI = 0.92–1.13). In the subgroup analysis by ethnicity, there is no significant association of this polymorphism and CALL risks among Asian and Caucasian populations in the three genetic models (CC vs CT + TT, CC + CT vs TT, and C vs T).

Conclusion

This meta-analysis found no significant association between the CEBPE rs2239633 polymorphism and susceptibility to CALL.
Literature
1.
2.
Terracini B. Epidemiology of childhood cancer. Environ Health 2011; 10 Suppl 1(Suppl 1):S8.
3.
Karathanasis NV, Choumerianou DM, Kalmanti M. Gene polymorphisms in childhood ALL. Pediatr Blood Cancer. 2008;52(3):318–23.CrossRef
4.
Bhojwani D, Yang JJ, Pui CH. Biology of childhood acute lymphoblastic leukemia. Pediatr Clin N Am. 2015;62(1):47–60.CrossRef
5.
Schuz J, Erdmann F. Environmental exposure and risk of childhood leukemia: an overview. Arch Med Res. 2016;47(8):607–14.PubMedCrossRef
6.
Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E, et al. Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. Nat Genet. 2009;41(9):1006–10.PubMedPubMedCentralCrossRef
7.
TrevnO LR, Yang W, French D, Hunger SP, Carroll WL, Devidas M, et al. Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nat Genet. 2009;41(9):1001–5.CrossRef
8.
Orsi L, Rudant J, Bonaventure A, Goujon-Bellec S, Corda E, Evans TJ, et al. Genetic polymorphisms and childhood acute lymphoblastic leukemia: GWAS of the ESCALE study (SFCE). Leukemia. 2012;26(12):2561–4.PubMedCrossRef
9.
Walsh KM, Chokkalingam AP, Hsu LI, Metayer C, de Smith AJ, Jacobs DI, et al. Associations between genome-wide native American ancestry, known risk alleles and B-cell ALL risk in Hispanic children. Leukemia. 2013;27(12):2416–9.PubMedCrossRef
10.
Akagi T, Thoennissen NH, George A, Crooks G, Song JH, Okamoto R, et al. In vivo deficiency of both C/EBPbeta and C/EBPepsilon results in highly defective myeloid differentiation and lack of cytokine response. PLoS One. 2010;5(11):e15419.PubMedPubMedCentralCrossRef
11.
Gharbi H, Ben Hassine I, Soltani I, Safra I, Ouerhani S, Bel Haj Othmen H, et al. Association of genetic variation in IKZF1, ARID5B, CDKN2A, and CEBPE with the risk of acute lymphoblastic leukemia in Tunisian children and their contribution to racial differences in leukemia incidence. Pediatr Hematol Oncol. 2016;33(3):157–67.PubMedCrossRef
12.
Akasaka T, Balasas T, Russell LJ, Sugimoto KJ, Majid A, Walewska R, et al. Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Blood. 2007;109(8):3451–61.PubMedCrossRef
13.
Wang C, Chen J, Sun H, Sun L, Liu Y. CEBPE polymorphism confers an increased risk of childhood acute lymphoblastic leukemia: a meta-analysis of 11 case-control studies with 5,639 cases and 10,036 controls. Ann Hematol. 2015;94(2):181–5.PubMedCrossRef
14.
Sun J, Zheng J, Tang L, Healy J, Sinnett D, Dai YE. Association between CEBPE variant and childhood acute leukemia risk: evidence from a meta-analysis of 22 studies. PLoS One. 2015;10(5):e0125657.PubMedPubMedCentralCrossRef
15.
Al-Absi B, Razif MFM, Noor SM, Saif-Ali R, Aqlan M, Salem SD, et al. Contributions of IKZF1, DDC, CDKN2A, CEBPE, and LMO1 gene polymorphisms to acute lymphoblastic leukemia in a Yemeni population. Genetic Test Mol Biomark. 2017;21(10):592–9.CrossRef
16.
Bekker-Mendez VC, Nunez-Enriquez JC, Torres Escalante JL, Alvarez-Olmos E, Gonzalez-Montalvoc PM, Jimenez-Hernandez E, et al. ARID5B, CEBPE and PIP4K2A germline genetic polymorphisms and risk of childhood acute lymphoblastic leukemia in Mexican patients: a MIGICCL study. Arch Med Res. 2016;47(8):623–8.PubMedCrossRef
17.
Bhandari P, Ahmad F, Mandava S, Das BR. Association of genetic variants in ARID5B, IKZF1 and CEBPE with risk of childhood de novo B-lineage acute lymphoblastic leukemia in India. Asian Pac J Cancer Prev. 2016;17(8):3989–95.PubMed
18.
Urayama KY, Takagi M, Kawaguchi T, Matsuo K, Tanaka Y, Ayukawa Y, et al. Regional evaluation of childhood acute lymphoblastic leukemia genetic susceptibility loci among Japanese. Sci Rep. 2018;8(1):789.PubMedPubMedCentralCrossRef
19.
Kreile M, Piekuse L, Rots D, Dobele Z, Kovalova Z, Lace B. Analysis of possible genetic risk factors contributing to development of childhood acute lymphoblastic leukaemia in the Latvian population. Arch Med Sci. 2016;12(3):479–85.PubMedPubMedCentralCrossRef
20.
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–9 w264.CrossRefPubMed
21.
Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603–5.CrossRefPubMed
22.
Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 21(11):1539–58.
23.
Zintzaras E, Lau J. Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches. J Clin Epidemiol. 2008;61(7):634–45.PubMedCrossRef
24.
25.
26.
Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ (Clinical research ed). 1997;315(7109):629–34.CrossRef
27.
Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50(4):1088–101.CrossRefPubMed
28.
Wada T, Akagi T. Role of the leucine zipper domain of CCAAT/enhancer binding protein-epsilon (C/EBPepsilon) in neutrophil-specific granule deficiency. Crit Rev Immunol. 2016;36(4):349–58.PubMedCrossRef
29.
Ellinghaus E, Stanulla M, Richter G, Ellinghaus D, te Kronnie G, Cario G, et al. Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Leukemia. 2012;26(5):902–9.PubMedCrossRef
30.
Prasad RB, Hosking FJ, Jayaram V, Elli P, Rolf K, Mel G, et al. Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood. Blood. 2010;115(9):1765–7.PubMedCrossRef
31.
Vijayakrishnan J, Sherborne AL, Sawangpanich R, Hongeng S, Houlston RS, Pakakasama S. Variation at 7p12.2 and 10q21.2 influences childhood acute lymphoblastic leukemia risk in the Thai population and may contribute to racial differences in leukemia incidence. Leukemia Lymphoma. 2010;51(10):1870–4.PubMedCrossRef
32.
Pastorczak A, Górniak P, Sherborne A, Hosking F, Trelińska J, Lejman M, et al. Role of 657del5 NBN mutation and 7p12.2 (IKZF1), 9p21 (CDKN2A), 10q21.2 (ARID5B) and 14q11.2 (CEBPE) variation and risk of childhood ALL in the polish population. Leuk Res. 2011;35(11):1534–6.PubMedCrossRef
33.
Lautner-Csorba O, Gezsi A, Semsei AF, Antal P, Erdelyi DJ, Schermann G, et al. Candidate gene association study in pediatric acute lymphoblastic leukemia evaluated by Bayesian network based Bayesian multilevel analysis of relevance. BMC Med Genet. 2012;5:42.
34.
Chokkalingam AP, Hsu LI, Metayer C, Hansen HM, Month SR, Barcellos LF, et al. Genetic variants in ARID5B and CEBPE are childhood ALL susceptibility loci in Hispanics. Cancer Causes Control. 2013;24(10):1789–95.PubMedPubMedCentralCrossRef
35.
Ross JA, Linabery AM, Blommer CN, Langer EK, Spector LG, Hilden JM, et al. Genetic variants modify susceptibility to leukemia in infants: a Children’s oncology group report. Pediatr Blood Cancer. 2013;60(1):31–4.PubMedCrossRef
36.
Wang Y, Chen J, Li J, Deng J, Rui Y, Lu Q, et al. Association of three polymorphisms in ARID5B, IKZF1 and CEBPE with the risk of childhood acute lymphoblastic leukemia in a Chinese population. Gene. 2013;524(2):203–7.PubMedCrossRef
37.
Emerenciano M, Barbosa TC, Lopes BA, Blunck CB, Faro A, Andrade C, et al. ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia. BMC Cancer. 2014;14:127.PubMedPubMedCentralCrossRef
Metadata
Title
The CEBPE rs2239633 genetic polymorphism on susceptibility to childhood acute lymphoblastic leukemia: an updated meta-analysis
Authors
Jin Liu
Gu Weiling
Li Xueqin
Xie Liang
Wang Linhong
Chen Zhongwen
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Environmental Health and Preventive Medicine / Issue 1/2021
Print ISSN: 1342-078X
Electronic ISSN: 1347-4715
DOI
https://doi.org/10.1186/s12199-020-00920-2

Other articles of this Issue 1/2021

Environmental Health and Preventive Medicine 1/2021 Go to the issue

Research article

Effect of IL-15 addition on asbestos-induced suppression of human cytotoxic T lymphocyte induction

Correction

Correction to: Effects of short-term exposure to ambient airborne pollutants on COPD-related mortality among the elderly residents of Chengdu city in Southwest China

Research article

Long-term participation in community-based group resistance exercises delays the transition from robustness to frailty in older adults: a retrospective cohort study

Research article

The willingness for dietary and behavioral changes in frontline epidemic prevention workers after experiencing the outbreak of COVID-19 in China: a cross-sectional study

Research article

Associations of education and income with hazardous drinking among postpartum women in Japan: results from the TMM BirThree Cohort Study

Research article

Associations between trunk-to-peripheral fat ratio and cardiometabolic risk factors in elderly Japanese men: baseline data from the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study