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Open Access 11-05-2024 | Acute Lymphoblastic Leukemia | Letter to the Editor

Plasmapheresis effectively abrogates severe liver toxicity of pegaspargase in a patient with acute lymphoblastic leukemia

Authors: Markus Tölle, Nicola Gökbuget, Stefan Habringer, Ulrich Keller, Stefan Schwartz

Excerpt

Dear Editor, …

Douer D, Gokbuget N, Stock W, Boissel N (2022) Optimizing use of L-asparaginase-based treatment of adults with acute lymphoblastic leukemia. Blood Rev 53:100908. https://doi.org/10.1016/j.blre.2021.100908CrossRefPubMed

Juluri KR, Siu C, Cassaday RD (2022) Asparaginase in the treatment of Acute lymphoblastic leukemia in adults: current evidence and place in Therapy. Blood Lymphat Cancer 12:55–79. https://doi.org/10.2147/BLCTT.S342052CrossRefPubMedPubMedCentral

Goekbuget N, Schwartz S, Faul C, Topp MS, Subklewe M, Renzelmann A, Stoltefuss A, Hertenstein B, Wilke A, Raffel S, Jäkel N, Vucinic V, Niemann DM, Reiser L, Serve H, Brüggemann M, Viardot A (2023) Dose reduced chemotherapy in sequence with Blinatumomab for newly diagnosed older patients with Ph/BCR::ABL negative B-Precursor adult lymphoblastic leukemia (ALL): preliminary results of the GMALL bold trial. Blood 142(Supplement 1):964–964. https://doi.org/10.1182/blood-2023-180472CrossRef

Pourhassan H, Douer D, Pullarkat V, Aldoss I (2023) Asparaginase: how to better manage toxicities in adults. Curr Oncol Rep 25(1):51–61. https://doi.org/10.1007/s11912-022-01345-6CrossRefPubMed

Bilgir O, Calan M, Bilgir F, Cagliyan G, Arslan O (2013) An experience with plasma exchange treatment of acute lymphoblastic leukemia in a case with fulminant hepatitis related to L-asparaginase. Transfus Apher Sci 49(2):328–330. https://doi.org/10.1016/j.transci.2013.06.010CrossRefPubMed

Gopel W, Schnetzke U, Hochhaus A, Scholl S (2016) Functional acute liver failure after treatment with pegylated asparaginase in a patient with acute lymphoblastic leukemia: potential impact of plasmapheresis. Ann Hematol 95(11):1899–1901. https://doi.org/10.1007/s00277-016-2773-0CrossRefPubMed

Title: Plasmapheresis effectively abrogates severe liver toxicity of pegaspargase in a patient with acute lymphoblastic leukemia
Authors: Markus Tölle
Nicola Gökbuget
Stefan Habringer
Ulrich Keller
Stefan Schwartz
Publication date: 11-05-2024
Publisher: Springer Berlin Heidelberg
Keywords: Acute Lymphoblastic Leukemia
Liver Function Test
Published in: Annals of Hematology
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-024-05789-7

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