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BMC Oral Health

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Open Access 01-12-2023 | Acute Lymphoblastic Leukemia | Research

Efficacy of recombinant human interleukin-11 in preventing and treating oral mucositis after chemotherapy for patients with acute leukemia

Authors: Yilin Zhang, Yuxin Li, Aili He, Jin Wang, Pengyu Zhang, Bo Lei, Zhuan Huang, Lin Zhang, Wei Zhao, Xiaorong Ma

Published in: BMC Oral Health | Issue 1/2023

Abstract

Objective

This study aimed to investigate the clinical effects of recombinant human interleukin-11 (rhIL-11) gargle on preventing and treating oral mucositis (OM) after chemotherapy for acute leukemia.

Methods

This single-site, prospective, observer-blinded, nonrandomized controlled trial was conducted on 74 patients with acute leukemia, who were divided into the experimental and control groups. The patients in the experimental group were treated with IL-11 gargle, and those in the control group were treated with sodium bicarbonate gargle. We examined the time and severity of oral mucositis, severity and duration of associated pain, healing time of mucositis, effects of OM on eating, and levels of T-cell subset indicators before and after treatment to evaluate the effects of IL-11 treatment.

Results

The proportion of patients with severe OM was significantly lower in the experimental group than in the control group. Mucositis occurred later in the experimental group compared with the control group. The degree and duration of pain, ulcer healing time, and effects on eating were lower in the experimental group compared with the control group. Following treatment, the levels of all T-cell subset indicators improved in each of the two groups. However, the rate of improvement was significantly higher in the experimental group than in the control group. These differences were statistically significant (P < 0.05).

Conclusions

IL-11 gargle reduced the severity of OM after chemotherapy for acute leukemia. Treatment with IL-11 relieved pain, promoted healing, and improved the curative effect of the condition, making it worthy of clinical promotion.

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Title: Efficacy of recombinant human interleukin-11 in preventing and treating oral mucositis after chemotherapy for patients with acute leukemia
Authors: Yilin Zhang
Yuxin Li
Aili He
Jin Wang
Pengyu Zhang
Bo Lei
Zhuan Huang
Lin Zhang
Wei Zhao
Xiaorong Ma
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Acute Lymphoblastic Leukemia
Cytostatic Therapy
Leukemia
Published in: BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI: https://doi.org/10.1186/s12903-023-03118-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Efficacy of recombinant human interleukin-11 in preventing and treating oral mucositis after chemotherapy for patients with acute leukemia

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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