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01-12-2014 | Original Article

Acute leukocyte, cytokine and adipocytokine responses to maximal and hypertrophic resistance exercise bouts

Authors: Johanna Ihalainen, Simon Walker, Gøran Paulsen, Keijo Häkkinen, William J. Kraemer, Mari Hämäläinen, Katriina Vuolteenaho, Eeva Moilanen, Antti A Mero

Published in: European Journal of Applied Physiology | Issue 12/2014

Abstract

The purpose of this study was to examine the acute immune response (circulating levels of leukocytes, cytokines and adipocytokines) to maximal resistance (MAX, 15 × 1RM) and hypertrophic resistance (HYP, 5 × 10RM) exercise bouts. Twelve healthy men (age = 28.2 ± 3.5 years, weight = 78.6 ± 10.4 kg, height 178.8 ± 5.0 cm, fat percentage = 16.5 ± 3.5 %) participated in the study. Blood was sampled before, immediately after and 15 and 30 min after exercise. Leukocytes (WBC) significantly increased immediately after HYP (p < 0.01), whereas in MAX, increases in WBC became significant after 30 min (p < 0.05). Lymphocytes increased only after HYP (p < 0.001), while MAX induced lymphopenia during recovery (p < 0.01). Monocyte chemoattractant protein-1 (MCP-1) decreased (p < 0.05) and interleukin-1 receptor antagonist (IL-1ra) increased after HYP, which were not observed after MAX. Adipsin and resistin decreased after both exercise bouts (p < 0.05), which suggest that heavy resistance exercise is at least transiently beneficial for adipocytokine profile. Immediate mechanical stress seemed similar as no differences in myoglobin response were observed. The higher magnitude of metabolic demand reflected in higher lactate response in HYP could be the reason for the significantly high responses in WBC, IL-1ra and decrease in MCP-1.

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Title: Acute leukocyte, cytokine and adipocytokine responses to maximal and hypertrophic resistance exercise bouts
Authors: Johanna Ihalainen
Simon Walker
Gøran Paulsen
Keijo Häkkinen
William J. Kraemer
Mari Hämäläinen
Katriina Vuolteenaho
Eeva Moilanen
Antti A Mero
Publication date: 01-12-2014
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 12/2014
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-014-2979-6

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Acute leukocyte, cytokine and adipocytokine responses to maximal and hypertrophic resistance exercise bouts

Abstract

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Acknowledgement to referees