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Open Access 01-11-2020 | Acute Kidney Injury | Invited review article

The need for disruptive innovation in acute kidney injury

Author: Kent Doi

Published in: Clinical and Experimental Nephrology | Issue 11/2020

Abstract

Acute kidney injury (AKI) is a threatening medical condition associated with poor outcomes at different settings. The development of standardized diagnostic criteria and new biomarkers addressed significant clinical impacts of AKI and the need for an early AKI detection, respectively. There have been some breakthroughs in understanding the pathogenesis of AKI through basic research; however, treatments against AKI aside from renal replacement therapy (RRT) have not shown adequate successful results. Biomarkers that could identify good responders to certain treatment are expected to facilitate translation of basic research findings. Most patients with severe AKI treated with RRT died due to multiple-organ failure, not renal dysfunction. Hence, it is essential to identify other organ dysfunctions induced by AKI as organ crosstalk. Also, a multidisciplinary approach of critical care nephrology is needed to evaluate a complex organ crosstalk in AKI. For disruptive innovation for AKI, we further explore these new aspects of AKI, which previously were considered outside the scope of nephrology.

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Title: The need for disruptive innovation in acute kidney injury
Author: Kent Doi
Publication date: 01-11-2020
Publisher: Springer Singapore
Keywords: Acute Kidney Injury
Septicemia
Septicemia
Care
Acute Kidney Injury
Biomarkers
Published in: Clinical and Experimental Nephrology / Issue 11/2020
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI: https://doi.org/10.1007/s10157-020-01920-w

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