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01-12-2020 | Acute Kidney Injury | Commentary

Acute kidney injury in SARS-CoV-2 infected patients

Authors: Vito Fanelli, Marco Fiorentino, Vincenzo Cantaluppi, Loreto Gesualdo, Giovanni Stallone, Claudio Ronco, Giuseppe Castellano

Published in: Critical Care | Issue 1/2020

Excerpt

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the pathogen responsible of atypical pneumonia that has affected more than 330,000 people and caused death of more than 14,000 patients (as of March 23, 2020, WHO Report). Coronavirus spike (S) glycoproteins mediate entry into cells end predominantly lung epithelial alveolar cells precipitating an interstitial pneumonia that evolves through acute respiratory distress syndrome (ARDS) [1]. Interestingly, about 25% of acute kidney injury (AKI) occurrence has been reported in this clinical setting [2, 3]. These data were recently confirmed by the Italian Report of “Istituto Superiore di Sanità” describing an incidence of 27.8% in more than 2000 patients (updated on 17 March) (https://www.epicentro.iss.it/coronavirus/bollettino/Report-COVID-2019_17_marzo-v2.pdf). In this commentary, we discuss possible mechanisms of the COVID-19-induced AKI, indicating potential new approaches for risk stratification of SARS-CoV-2 infected patients that may help clinical decision in this emerging scenario. …

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Title: Acute kidney injury in SARS-CoV-2 infected patients
Authors: Vito Fanelli
Marco Fiorentino
Vincenzo Cantaluppi
Loreto Gesualdo
Giovanni Stallone
Claudio Ronco
Giuseppe Castellano
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Acute Kidney Injury
SARS-CoV-2
Acute Respiratory Distress-Syndrome
Acute Kidney Injury
Published in: Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-020-02872-z

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Acute kidney injury in SARS-CoV-2 infected patients

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