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Journal of Anesthesia
Published in: Journal of Anesthesia 4/2020

01-08-2020 | Acute Kidney Injury | Review Article

A “crush” course on rhabdomyolysis: risk stratification and clinical management update for the perioperative clinician

Authors: Devan R. Cote, Eva Fuentes, Ali H. Elsayes, Jonathan J. Ross, Sadeq A. Quraishi

Published in: Journal of Anesthesia | Issue 4/2020

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Abstract

Rhabdomyolysis, the release of myoglobin and other cellular breakdown products from necrotic muscle tissue, is seen in patients with crush injuries, drug overdose, malignant hyperthermia, muscular dystrophy, and with increasing frequency in obese patients undergoing routine procedures. For the perioperative clinician, managing the resultant shock, hyperkalemia, acidosis, and myoglobinuric acute kidney injury can present a significant challenge. Prompt recognition, hydration, and correction of metabolic disturbances may reduce or eliminate the need for long-term renal replacement therapy. This article reviews the pathophysiology and discusses key issues in the perioperative diagnosis, risk stratification, and management of rhabdomyolysis.
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Metadata
Title
A “crush” course on rhabdomyolysis: risk stratification and clinical management update for the perioperative clinician
Authors
Devan R. Cote
Eva Fuentes
Ali H. Elsayes
Jonathan J. Ross
Sadeq A. Quraishi
Publication date
01-08-2020
Publisher
Springer Singapore
Published in
Journal of Anesthesia / Issue 4/2020
Print ISSN: 0913-8668
Electronic ISSN: 1438-8359
DOI
https://doi.org/10.1007/s00540-020-02792-w

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