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Open Access 01-12-2019 | Acute Kidney Injury | Research

Associations between tricuspid annular plane systolic excursion to reflect right ventricular function and acute kidney injury in critically ill patients: a SICS-I sub-study

Authors: Renske Wiersema, Jacqueline Koeze, Bart Hiemstra, Ville Pettilä, Anders Perner, Frederik Keus, Iwan C. C. van der Horst, SICS Study Group

Published in: Annals of Intensive Care | Issue 1/2019

Abstract

Background

Acute kidney injury (AKI) occurs in up to 50% of all critically ill patients and hemodynamic abnormalities are assumed to contribute, but their nature and share is still unclear. We explored the associations between hemodynamic variables, including cardiac index and right ventricular function, and the occurrence of AKI in critically ill patients.

Methods

In this prospective cohort study, we included all patients acutely admitted to an intensive care unit (ICU). Within 24 h after ICU admission clinical and hemodynamic variables were registered including ultrasonographic measurements of cardiac index and right ventricular function, assessed using tricuspid annular plane systolic excursion (TAPSE) and right ventricular systolic excursion (RV S’). Maximum AKI stage was assessed according to the KDIGO criteria during the first 72 h after admission. Multivariable logistic regression modeling was used including both known predictors and univariable significant predictors of AKI. Secondary outcomes were days alive outside ICU and 90-day mortality.

Results

A total of 622 patients were included, of which 338 patients (54%) had at least AKI stage 1 within 72 h after ICU admission. In the final multivariate model higher age (OR 1.01, 95% CI 1.00–1.03, for each year), higher weight (OR 1.03 CI 1.02–1.04, for each kg), higher APACHE IV score (OR 1.02, CI 1.01–1.03, per point), lower mean arterial pressure (OR 1.02, CI 1.01–1.03, for each mmHg decrease) and lower TAPSE (OR 1.05, CI 1.02–1.09 per millimeter decrease) were all independent predictors for AKI in the final multivariate logistic regression model. Sepsis, cardiac index, RV S’ and use of vasopressors were not significantly associated with AKI in our data. AKI patients had fewer days alive outside of ICU, and their mortality rate was significantly higher than those without AKI.

Conclusions

In our cohort of acutely admitted ICU patients, the incidence of AKI was 54%. Hemodynamic variables were significantly different between patients with and without AKI. A worse right ventricle function was associated with AKI in the final model, whereas cardiac index was not.

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Title: Associations between tricuspid annular plane systolic excursion to reflect right ventricular function and acute kidney injury in critically ill patients: a SICS-I sub-study
Authors: Renske Wiersema
Jacqueline Koeze
Bart Hiemstra
Ville Pettilä
Anders Perner
Frederik Keus
Iwan C. C. van der Horst
SICS Study Group
Publication date: 01-12-2019
Publisher: Springer International Publishing
Keywords: Acute Kidney Injury
Care
Acute Kidney Injury
Published in: Annals of Intensive Care / Issue 1/2019
Electronic ISSN: 2110-5820
DOI: https://doi.org/10.1186/s13613-019-0513-z

At a glance: The STEP trials

Springer Medicine

Associations between tricuspid annular plane systolic excursion to reflect right ventricular function and acute kidney injury in critically ill patients: a SICS-I sub-study

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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