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Intensive Care Medicine

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01-05-2011 | Original

Acute kidney injury in patients with influenza A (H1N1) 2009

Authors: Ville Pettilä, Steven A. R. Webb, Michael Bailey, Belinda Howe, Ian M. Seppelt, Rinaldo Bellomo

Published in: Intensive Care Medicine | Issue 5/2011

Abstract

Objective

We aim to evaluate the incidence and outcome of acute kidney injury (AKI) among critically ill adult patients with H1N1 2009 infection.

Design and patients

From a prospectively collected influenza A (H1N1) 2009 bi-national, we identified 671 adult patients admitted to intensive care unit (ICU) from June 1 to August 31, 2009. Of these, 628 (93.6%) had admission and/or peak serum creatinine values during ICU stay. We defined AKI according to the creatinine criteria of the RIFLE classification.

Results

Of 628 adult patients, 211 [33.6%, 95% confidence interval (CI) 29.8–37.4%] had AKI: 41 (6.5%) risk, 56 (8.9%) injury and 114 (18.2%) failure. Of all 211 AKI patients, 76 [36.0% (29.4–42.6%)] died in hospital (36.6% in risk, 25.0% in injury and 41.3% in failure group) compared with 33 of 408 (8.1%) patients without AKI. Among the 33 AKI patients treated with renal replacement therapy, 13 died (39.4%). Mechanical ventilation [odds ratio (OR) 3.62 (2.07–6.34)], any severe co-morbidity (OR 2.36, 95% CI 1.15–3.71), age (OR 1.02, 95% CI 1.01–1.03 per 1 year increase), and AKI (OR 6.69, 95% CI 4.25–10.55) were independently associated with hospital mortality.

Conclusions

Acute kidney injury appears common in H1N1 2009 infected patients and is independently associated with an increased risk of hospital mortality.

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Title: Acute kidney injury in patients with influenza A (H1N1) 2009
Authors: Ville Pettilä
Steven A. R. Webb
Michael Bailey
Belinda Howe
Ian M. Seppelt
Rinaldo Bellomo
Publication date: 01-05-2011
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 5/2011
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-011-2166-8

At a glance: The STEP trials

Springer Medicine

Acute kidney injury in patients with influenza A (H1N1) 2009

Abstract

Objective

Design and patients

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Design and patients

Results

Conclusions

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