Published in:
01-05-2011 | Editorial
Severe viral infection and the kidney: lessons learned from the H1N1 pandemic
Authors:
Michael Joannidis, Lui G. Forni
Published in:
Intensive Care Medicine
|
Issue 5/2011
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Excerpt
Through the development and application of the risk of renal failure, injury to the kidney, failure of kidney function, loss of kidney function, and end-stage kidney disease (RIFLE)/Acute Kidney Injury Network (AKIN) criteria for acute kidney injury, uncertainties about definitions have finally ended [
1]. However, the term acute kidney injury (AKI) shares some similarities with that of acute respiratory distress syndrome (ARDS) given that these ‘definitions’ provide no information as to the underlying specific aetiologies. Clearly the cause of AKI determines treatment but also has been shown to influence both prognosis and outcome [
2]; for example, sepsis-related AKI is associated with particularly high mortality rates approaching 70% in some studies [
3] and is usually attributed to bacterial infections, less so to fungal causes and rarely to a viral aetiology [
4]. …