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BMC Complementary Medicine and Therapies

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01-12-2021 | Acupuncture | Research article

Acupuncture for post-stroke depression: a systematic review and meta-analysis

Authors: Ran Liu, Kun Zhang, Qiu-yu Tong, Guang-wei Cui, Wen Ma, Wei-dong Shen

Published in: BMC Complementary Medicine and Therapies | Issue 1/2021

Abstract

Background

Acupuncture for post-stroke depression (PSD) has been evolving, but uncertainty remains. To assess the existing evidence from randomized clinical trials (RCTs) of acupuncture for PSD, we sought to draw conclusions by synthesizing RCTs.

Methods

An exhaustive literature search was conducted in seven electronic databases from their inception dates to April 19, 2020, to identify systematic reviews (SRs) and meta-analyses (MAs) on this topic. The primary RCTs included in the SRs/MAs were identified. We also conducted a supplementary search for RCTs published from January 1, 2015, to May 12, 2020. Two reviewers extracted data separately and pooled data using RevMan 5.3 software. The quality of evidence was critically appraised with the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) system.

Results

A total of 17 RCTs involving 1402 patients were included. Meta-analysis showed that participants who received a combination of acupuncture and conventional treatments exhibited significantly lower scores on the HAM-D₁₇, HAM-D₂₄ and HAM-D (MD, − 5.08 [95% CI, − 6.48 to − 3.67], I² = 0%), (MD, − 9.72 [95% CI, − 14.54 to − 4.91], I² = 65%) and (MD, − 2.72 [95% CI, − 3.61 to − 1.82], respectively) than those who received conventional treatment. However, there was no significant difference in acupuncture versus antidepressants in terms of the 17-item, 24-item and HAM-D scales (MD, − 0.43 [95% CI, − 1.61 to 0.75], I² = 51%), (MD, − 3.09 [95% CI, − 10.81 to 4.63], I² = 90%) and (MD, − 1.55 [95% CI, − 4.36 to 1.26], I² = 95%, respectively). For adverse events, acupuncture was associated with fewer adverse events than antidepressants (RR, 0.16 [95% CI, 0.07 to 0.39], I² = 35%), but there was no significant difference in the occurrence of adverse events between the combination of acupuncture and conventional treatments versus conventional treatments (RR, 0.63 [95% CI, 0.21 to 1.83], I² = 38%). The quality of evidence was low to very low due to the substantial heterogeneity among the included studies.

Conclusions

The current review indicates that acupuncture has greater effect on PSD and better safety profile than antidepressants, but high-quality evidence evaluating acupuncture for PSD is still needed.

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Title: Acupuncture for post-stroke depression: a systematic review and meta-analysis
Authors: Ran Liu
Kun Zhang
Qiu-yu Tong
Guang-wei Cui
Wen Ma
Wei-dong Shen
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Acupuncture
Antidepressant Drugs
Stroke
Mood Disorders
Affective Disorder
Antidepressant Drugs
Fluoxetine
Published in: BMC Complementary Medicine and Therapies / Issue 1/2021
Electronic ISSN: 2662-7671
DOI: https://doi.org/10.1186/s12906-021-03277-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Acupuncture for post-stroke depression: a systematic review and meta-analysis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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