Skip to main content
Top
Published in: Journal of NeuroVirology 3/2020

01-06-2020 | Acupuncture | Short Communication

Acupuncture in the treatment of HTLV-I-associated myelopathy / tropical spastic Paraparesis

Authors: Ali Shoeibi, SeyedJavad Mojtabavi, Reza Boostani, Mohammad Sobhan Sheikh Andalibi, Houshang Rafatpanah, Mohammadmahdi Etemadi, Zohreh Poursina, Amirali Ghahremani

Published in: Journal of NeuroVirology | Issue 3/2020

Login to get access

Abstract

We investigate the possible effects of acupuncture on the improvement of neurological problems in HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)disease. Twenty patients with HAM/TSP were studied in this pre and post-test clinical trial. Urinary incontinence, global motor disability, spasticity, and pain severity were evaluated before, one month, and three-month after the intervention. Analyses demonstrated a significant reduction of urinary symptoms one month after acupuncture (P = 0.023). A significant improvement was observed in patients’ pain and the spasticity at the upper extremity joints, one and three-month after the intervention (P < 0.05). This study suggests that body acupuncture can be used as a complementary treatment to improve HAM/TSP neurological symptoms.
Literature
go back to reference Araya N, Sato T, Coler-Reilly A, Yagishita N, Yamano Y (2016) Developing novel treatments for HTLV-1-associated myelopathy (HAM) by investigating molecular pathomechanisms. Nihon Rinshō Men'eki Gakkai Kaishi 39(3):207PubMedCrossRef Araya N, Sato T, Coler-Reilly A, Yagishita N, Yamano Y (2016) Developing novel treatments for HTLV-1-associated myelopathy (HAM) by investigating molecular pathomechanisms. Nihon Rinshō Men'eki Gakkai Kaishi 39(3):207PubMedCrossRef
go back to reference Avery K, Donovan J, Peters TJ, Shaw C, Gotoh M, Abrams P (2004) ICIQ: a brief and robust measure for evaluating the symptoms and impact of urinary incontinence. Neurourol Urodyn 23(4):322–330PubMedCrossRef Avery K, Donovan J, Peters TJ, Shaw C, Gotoh M, Abrams P (2004) ICIQ: a brief and robust measure for evaluating the symptoms and impact of urinary incontinence. Neurourol Urodyn 23(4):322–330PubMedCrossRef
go back to reference Bangham CR, Araujo A, Yamano Y, Taylor GP (2015) HTLV-1-associated myelopathy/tropical spastic paraparesis. Nat Rev Dis Prim 1(15012):15012PubMedCrossRef Bangham CR, Araujo A, Yamano Y, Taylor GP (2015) HTLV-1-associated myelopathy/tropical spastic paraparesis. Nat Rev Dis Prim 1(15012):15012PubMedCrossRef
go back to reference Bohannon RW, Smith MB (1987) Interrater reliability of a modified Ashworth scale of muscle spasticity. Phys Ther 67(2):206–207PubMedCrossRef Bohannon RW, Smith MB (1987) Interrater reliability of a modified Ashworth scale of muscle spasticity. Phys Ther 67(2):206–207PubMedCrossRef
go back to reference Boostani R, Ghabeli Juibary A (2014) Acute human T-lymphotropic virus type I-associated myelitis: a rare case successfully treated with intravenous pulse methylprednisolone. J Neuro-Oncol 20(4):423–425 Boostani R, Ghabeli Juibary A (2014) Acute human T-lymphotropic virus type I-associated myelitis: a rare case successfully treated with intravenous pulse methylprednisolone. J Neuro-Oncol 20(4):423–425
go back to reference Boostani R, Saber H, Etemadi M (2013) Effects of Danazol on clinical improvement of patients with human T-cell Lymphotropic virus type I associated myelopathy/tropical spastic Paraparesis (HAM/TSP): a placebo-controlled clinical trial. Iran J Basic Med Sci 16(3):213–216PubMedPubMedCentral Boostani R, Saber H, Etemadi M (2013) Effects of Danazol on clinical improvement of patients with human T-cell Lymphotropic virus type I associated myelopathy/tropical spastic Paraparesis (HAM/TSP): a placebo-controlled clinical trial. Iran J Basic Med Sci 16(3):213–216PubMedPubMedCentral
go back to reference Boostani R, Vakili R, Hosseiny SS, Shoeibi A, Fazeli B, Etemadi MM, Sabet F, Valizade N, Rezaee SA (2015) Triple therapy with prednisolone, Pegylated interferon and sodium valproate improves clinical outcome and reduces human T-cell leukemia virus type 1 (HTLV-1) Proviral load, tax and HBZ mRNA expression in patients with HTLV-1-associated myelopathy/tropical spastic Paraparesis. Neurotherapeutics 12(4):887–895PubMedPubMedCentralCrossRef Boostani R, Vakili R, Hosseiny SS, Shoeibi A, Fazeli B, Etemadi MM, Sabet F, Valizade N, Rezaee SA (2015) Triple therapy with prednisolone, Pegylated interferon and sodium valproate improves clinical outcome and reduces human T-cell leukemia virus type 1 (HTLV-1) Proviral load, tax and HBZ mRNA expression in patients with HTLV-1-associated myelopathy/tropical spastic Paraparesis. Neurotherapeutics 12(4):887–895PubMedPubMedCentralCrossRef
go back to reference Coler-Reilly AL, Sato T, Matsuzaki T, Nakagawa M, Niino M, Nagai M, Nakamura T, Takenouchi N, Araya N, Yagishita N (2017) Effectiveness of daily prednisolone to slow progression of human T-Lymphotropic virus type 1-associated myelopathy/tropical spastic Paraparesis: a multicenter retrospective cohort study. Neurotherapeutics 14(4):1084–1094PubMedPubMedCentralCrossRef Coler-Reilly AL, Sato T, Matsuzaki T, Nakagawa M, Niino M, Nagai M, Nakamura T, Takenouchi N, Araya N, Yagishita N (2017) Effectiveness of daily prednisolone to slow progression of human T-Lymphotropic virus type 1-associated myelopathy/tropical spastic Paraparesis: a multicenter retrospective cohort study. Neurotherapeutics 14(4):1084–1094PubMedPubMedCentralCrossRef
go back to reference Hinuma Y, Nagata K, Hanaoka M, Nakai M, Matsumoto T, Kinoshita KI, Shirakawa S, Miyoshi I (1981) Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci U S A 78(10):6476–6480PubMedPubMedCentralCrossRef Hinuma Y, Nagata K, Hanaoka M, Nakai M, Matsumoto T, Kinoshita KI, Shirakawa S, Miyoshi I (1981) Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci U S A 78(10):6476–6480PubMedPubMedCentralCrossRef
go back to reference Jenkins M (1990) A new standard international acupuncture nomenclature. Acupunct Med 7(1):21–22CrossRef Jenkins M (1990) A new standard international acupuncture nomenclature. Acupunct Med 7(1):21–22CrossRef
go back to reference Koyama RVL, Yoshikawa GT, Fujihara S, Da Silva Dias GA, Virgolino RR, Rodrigues AR, Medeiros R, Simões Quaresma JA, Fuzii HT (2019) Incomplete myelopathy and human T cell lymphotropic virus type-1 (HTLV-1). J Neuro-Oncol 25(1):1–8 Koyama RVL, Yoshikawa GT, Fujihara S, Da Silva Dias GA, Virgolino RR, Rodrigues AR, Medeiros R, Simões Quaresma JA, Fuzii HT (2019) Incomplete myelopathy and human T cell lymphotropic virus type-1 (HTLV-1). J Neuro-Oncol 25(1):1–8
go back to reference Lee JD, Chon J, Jeong H, Kim H, Yun M, Kim D, Kim D, Park C, Yoo H (2003) The cerebrovascular response to traditional acupuncture after stroke. Neuroradiology 45(11):780–784PubMedCrossRef Lee JD, Chon J, Jeong H, Kim H, Yun M, Kim D, Kim D, Park C, Yoo H (2003) The cerebrovascular response to traditional acupuncture after stroke. Neuroradiology 45(11):780–784PubMedCrossRef
go back to reference Levin MC, Jacobson S (1997) HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP): a chronic progressive neurologic disease associated with immunologically mediated damage to the central nervous system. J Neuro-Oncol 3(2):126–140 Levin MC, Jacobson S (1997) HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP): a chronic progressive neurologic disease associated with immunologically mediated damage to the central nervous system. J Neuro-Oncol 3(2):126–140
go back to reference Lim SM, Yoo J, Lee E, Kim HJ, Shin S (2015) Acupuncture for spasticity after stroke: a systematic review and meta-analysis of randomized controlled trials. Evid Based Complement Alternat Med 2015:870398PubMedPubMedCentral Lim SM, Yoo J, Lee E, Kim HJ, Shin S (2015) Acupuncture for spasticity after stroke: a systematic review and meta-analysis of randomized controlled trials. Evid Based Complement Alternat Med 2015:870398PubMedPubMedCentral
go back to reference Macpherson H, Altman DG, Hammerschlag R, Youping L, Taixiang W, White A, Moher D (2010) Revised standards for reporting interventions in clinical trials of acupuncture (STRICTA): extending the CONSORT statement. J Evid Based Med 3(3):140–155PubMedCrossRef Macpherson H, Altman DG, Hammerschlag R, Youping L, Taixiang W, White A, Moher D (2010) Revised standards for reporting interventions in clinical trials of acupuncture (STRICTA): extending the CONSORT statement. J Evid Based Med 3(3):140–155PubMedCrossRef
go back to reference Martin F, Castro H, Gabriel C, Adonis A, Fedina A, Harrison L, Brodnicki L, Demontis MA, Babiker AG, Weber JN (2012) Ciclosporin a proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis. PLoS Negl Trop Dis 6(6):e1675PubMedPubMedCentralCrossRef Martin F, Castro H, Gabriel C, Adonis A, Fedina A, Harrison L, Brodnicki L, Demontis MA, Babiker AG, Weber JN (2012) Ciclosporin a proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis. PLoS Negl Trop Dis 6(6):e1675PubMedPubMedCentralCrossRef
go back to reference Martins ML, Guimarães JC, Ribas JG, Romanelli LCF, De Freitas Carneiro-Proietti AB (2017) Long-term follow-up of HTLV-1 proviral load in asymptomatic carriers and in incident cases of HAM/TSP: what is its relevance as a prognostic marker for neurologic disease? J Neuro-Oncol 23(1):125–133 Martins ML, Guimarães JC, Ribas JG, Romanelli LCF, De Freitas Carneiro-Proietti AB (2017) Long-term follow-up of HTLV-1 proviral load in asymptomatic carriers and in incident cases of HAM/TSP: what is its relevance as a prognostic marker for neurologic disease? J Neuro-Oncol 23(1):125–133
go back to reference Matsuura E, Nozuma S, Tashiro Y, Kubota R, Izumo S, Takashima H (2016) HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): a comparative study to identify factors that influence disease progression. J Neurol Sci 371:112–116PubMedCrossRef Matsuura E, Nozuma S, Tashiro Y, Kubota R, Izumo S, Takashima H (2016) HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): a comparative study to identify factors that influence disease progression. J Neurol Sci 371:112–116PubMedCrossRef
go back to reference Myles PS, Troedel S, Boquest M, Reeves M (1999) The pain visual analog scale: is it linear or nonlinear? Anesth Analg 89(6):1517PubMed Myles PS, Troedel S, Boquest M, Reeves M (1999) The pain visual analog scale: is it linear or nonlinear? Anesth Analg 89(6):1517PubMed
go back to reference Najm WI (2010) Acupuncture in poststroke rehabilitation: a systematic review and meta-analysis of randomized trials. Med Acupunct 22(3):228–230CrossRef Najm WI (2010) Acupuncture in poststroke rehabilitation: a systematic review and meta-analysis of randomized trials. Med Acupunct 22(3):228–230CrossRef
go back to reference Nakagawa M, Nakahara K, Maruyama Y, Kawabata M, Higuchi I, Kubota H, Izumo S, Arimura K, Osame M (1996) Therapeutic trials in 200 patients with HTLV-I-associated myelopathy/ tropical spastic paraparesis. J Neuro-Oncol 2(5):345–355 Nakagawa M, Nakahara K, Maruyama Y, Kawabata M, Higuchi I, Kubota H, Izumo S, Arimura K, Osame M (1996) Therapeutic trials in 200 patients with HTLV-I-associated myelopathy/ tropical spastic paraparesis. J Neuro-Oncol 2(5):345–355
go back to reference Nakamura T, Matsuo T, Fukuda T, Yamato S, Yamaguchi K, Kinoshita I, Matsuzaki T, Nishiura Y, Nagasato K, Narita-Masuda T (2013) Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial. BMC Med 11(1):182PubMedPubMedCentralCrossRef Nakamura T, Matsuo T, Fukuda T, Yamato S, Yamaguchi K, Kinoshita I, Matsuzaki T, Nishiura Y, Nagasato K, Narita-Masuda T (2013) Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial. BMC Med 11(1):182PubMedPubMedCentralCrossRef
go back to reference Nakamura T, Satoh K, Fukuda T, Kinoshita I, Nishiura Y, Nagasato K, Yamauchi A, Kataoka Y, Nakamura T, Sasaki H (2014) Pentosan polysulfate treatment ameliorates motor function with increased serum soluble vascular cell adhesion molecule-1 in HTLV-1-associated neurologic disease. J Neuro-Oncol 20(3):269–277 Nakamura T, Satoh K, Fukuda T, Kinoshita I, Nishiura Y, Nagasato K, Yamauchi A, Kataoka Y, Nakamura T, Sasaki H (2014) Pentosan polysulfate treatment ameliorates motor function with increased serum soluble vascular cell adhesion molecule-1 in HTLV-1-associated neurologic disease. J Neuro-Oncol 20(3):269–277
go back to reference Oh U, Jacobson S (2008) Treatment of HTLV-I-associated myelopathy/tropical spastic paraparesis: toward rational targeted therapy. Neurol Clin 26(3):781–797 ix-xPubMedPubMedCentralCrossRef Oh U, Jacobson S (2008) Treatment of HTLV-I-associated myelopathy/tropical spastic paraparesis: toward rational targeted therapy. Neurol Clin 26(3):781–797 ix-xPubMedPubMedCentralCrossRef
go back to reference Osame M, Igata A, Matsumoto M, Kohka M, Usuku K, Izumo S (1989) HTLV-I-associated myelopathy (HAM) treatment trials, retrospective survey and clinical and laboratory findings. Hematol Rev Commun 3(4):271–284 Osame M, Igata A, Matsumoto M, Kohka M, Usuku K, Izumo S (1989) HTLV-I-associated myelopathy (HAM) treatment trials, retrospective survey and clinical and laboratory findings. Hematol Rev Commun 3(4):271–284
go back to reference Paik SH, Han SR, Kwon OJ, Ahn YM, Lee BC, Ahn SY (2013) Acupuncture for the treatment of urinary incontinence: a review of randomized controlled trials. Exp Ther Med 6(3):773–780PubMedPubMedCentralCrossRef Paik SH, Han SR, Kwon OJ, Ahn YM, Lee BC, Ahn SY (2013) Acupuncture for the treatment of urinary incontinence: a review of randomized controlled trials. Exp Ther Med 6(3):773–780PubMedPubMedCentralCrossRef
go back to reference Panel, O (2006) Ottawa panel evidence-based clinical practice guidelines for post-stroke rehabilitation. Top Stroke Rehabil 13(2):1–269CrossRef Panel, O (2006) Ottawa panel evidence-based clinical practice guidelines for post-stroke rehabilitation. Top Stroke Rehabil 13(2):1–269CrossRef
go back to reference Rafatpanah H, Rezaee A, Etemadi MM, Hosseini RF, Khorram B, Afsahr L, Taylor G, Mokhber N, Mahmoudi M, Abbaszadegan MR (2012) The impact of interferon-alpha treatment on clinical and immunovirological aspects of HTLV-1-associated myelopathy in northeast of Iran. J Neuroimmunol 250(1-2):87–93PubMedCrossRef Rafatpanah H, Rezaee A, Etemadi MM, Hosseini RF, Khorram B, Afsahr L, Taylor G, Mokhber N, Mahmoudi M, Abbaszadegan MR (2012) The impact of interferon-alpha treatment on clinical and immunovirological aspects of HTLV-1-associated myelopathy in northeast of Iran. J Neuroimmunol 250(1-2):87–93PubMedCrossRef
go back to reference Saeidi M, Sasannejad P, Foroughipour M, Shahami S, Shoeibi A (2011) Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Acta Neurol Belg 111(1):41–44PubMed Saeidi M, Sasannejad P, Foroughipour M, Shahami S, Shoeibi A (2011) Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Acta Neurol Belg 111(1):41–44PubMed
go back to reference Salehi M, Shokouhi Mostafavi SK, Ghasemian A, Gholami M, Kazemi-Vardanjani A, Rahimi MK (2017) Seroepidemiology of HTLV-1 and HTLV-2 infection in Neyshabur City, north-eastern Iran, during 2010-2014. Iran Biomed J 21(1):57–60PubMedPubMedCentralCrossRef Salehi M, Shokouhi Mostafavi SK, Ghasemian A, Gholami M, Kazemi-Vardanjani A, Rahimi MK (2017) Seroepidemiology of HTLV-1 and HTLV-2 infection in Neyshabur City, north-eastern Iran, during 2010-2014. Iran Biomed J 21(1):57–60PubMedPubMedCentralCrossRef
go back to reference Shibata D, Brynes RK, Rabinowitz A, Hanson CA, Slovak ML, Spira TJ, Gill P (1989) Human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia-lymphoma in a patient infected with human immunodeficiency virus type 1 (HIV-1). Ann Intern Med 111(11):871–875PubMedCrossRef Shibata D, Brynes RK, Rabinowitz A, Hanson CA, Slovak ML, Spira TJ, Gill P (1989) Human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia-lymphoma in a patient infected with human immunodeficiency virus type 1 (HIV-1). Ann Intern Med 111(11):871–875PubMedCrossRef
go back to reference Shoeibi A, Rafatpanah H, Azarpazhooh A, Mokhber N, Hedayati-Moghaddam MR, Amiri A, Hashemi P, Foroghipour M, Hoseini RF, Bazarbachi A, Azarpazhooh MR (2013) Clinical features of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Northeast Iran. Acta Neurol Belg 113(4):427–433PubMedCrossRef Shoeibi A, Rafatpanah H, Azarpazhooh A, Mokhber N, Hedayati-Moghaddam MR, Amiri A, Hashemi P, Foroghipour M, Hoseini RF, Bazarbachi A, Azarpazhooh MR (2013) Clinical features of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Northeast Iran. Acta Neurol Belg 113(4):427–433PubMedCrossRef
go back to reference Taylor GP, Goon P, Furukawa Y, Green H, Barfield A, Mosley A, Nose H, Babiker A, Rudge P, Usuku K (2006) Zidovudine plus lamivudine in human T-Lymphotropic virus type-I-associated myelopathy: a randomised trial. Retrovirology 3(1):63PubMedPubMedCentralCrossRef Taylor GP, Goon P, Furukawa Y, Green H, Barfield A, Mosley A, Nose H, Babiker A, Rudge P, Usuku K (2006) Zidovudine plus lamivudine in human T-Lymphotropic virus type-I-associated myelopathy: a randomised trial. Retrovirology 3(1):63PubMedPubMedCentralCrossRef
go back to reference Yang A, Wu HM, Tang JL, Xu L, Yang M, Liu GJ (2016) Acupuncture for stroke rehabilitation. Cochrane Database Syst Rev Yang A, Wu HM, Tang JL, Xu L, Yang M, Liu GJ (2016) Acupuncture for stroke rehabilitation. Cochrane Database Syst Rev
go back to reference Yuan Z, He C, Yan S, Huang D, Wang H, Tang W (2015) Acupuncture for overactive bladder in female adult: a randomized controlled trial. World J Urol 33(9):1303–1308PubMedCrossRef Yuan Z, He C, Yan S, Huang D, Wang H, Tang W (2015) Acupuncture for overactive bladder in female adult: a randomized controlled trial. World J Urol 33(9):1303–1308PubMedCrossRef
go back to reference Zhou W, Wang LP (2005) Observation on therapeutic effect of abdominal acupuncture on spastic paralysis after cerebrovascular disorder. Zhongguo Zhen Jiu 25(11):757–759PubMed Zhou W, Wang LP (2005) Observation on therapeutic effect of abdominal acupuncture on spastic paralysis after cerebrovascular disorder. Zhongguo Zhen Jiu 25(11):757–759PubMed
Metadata
Title
Acupuncture in the treatment of HTLV-I-associated myelopathy / tropical spastic Paraparesis
Authors
Ali Shoeibi
SeyedJavad Mojtabavi
Reza Boostani
Mohammad Sobhan Sheikh Andalibi
Houshang Rafatpanah
Mohammadmahdi Etemadi
Zohreh Poursina
Amirali Ghahremani
Publication date
01-06-2020
Publisher
Springer International Publishing
Keyword
Acupuncture
Published in
Journal of NeuroVirology / Issue 3/2020
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI
https://doi.org/10.1007/s13365-019-00805-3

Other articles of this Issue 3/2020

Journal of NeuroVirology 3/2020 Go to the issue