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01-12-2013 | Original Article

Clinical features of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in northeast Iran

Authors: Ali Shoeibi, Houshang Rafatpanah, Amir Azarpazhooh, Naghme Mokhber, Mohammad Reza Hedayati-Moghaddam, Amin Amiri, Peyman Hashemi, Mohsen Foroghipour, Reza Farid Hoseini, Ali Bazarbachi, Mahmoud Reza Azarpazhooh

Published in: Acta Neurologica Belgica | Issue 4/2013

Abstract

This study aimed to introduce clinical manifestations of patients in northeast Iran with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and describe the epidemiological features, as well as risk factors for HTLV-1 infection. This is a cross-sectional study of HTLV-1 infected cases and HAM/TSP patients referred by outpatient neurology clinics as well as Mashhad Blood Transfusion Center from 2005 to 2010. The study comprises 513 cases, including 358 healthy carriers (HCs) and 145 HAM/TSP patients. The majority of carriers were male (73.5 %), whereas 67.6 % of HAM/TSP sufferers were female (P < 0.001). The mean age of HAM/TSP patients and HCs was 45.9 ± 13.6 and 39.5 ± 11.58 years, respectively (P < 0.001). The history of transfusion, surgery, hospitalization and cupping was observed in a significant greater number of HAM/TSP patients than the HCs (P < 0.001, P < 0.001, P < 0.001 and P = 0.029, respectively). Gait disturbance was the most common complaint in HAM/TSP patients (72.4 %). This research develops an HTLV-1 data registry in an endemic area such as Mashhad which can serve useful purposes, including evaluation of clinical and laboratory characteristics of HAM/TSP patients and epidemiological data of HTLV-1-infected cases.

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Title: Clinical features of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in northeast Iran
Authors: Ali Shoeibi
Houshang Rafatpanah
Amir Azarpazhooh
Naghme Mokhber
Mohammad Reza Hedayati-Moghaddam
Amin Amiri
Peyman Hashemi
Mohsen Foroghipour
Reza Farid Hoseini
Ali Bazarbachi
Mahmoud Reza Azarpazhooh
Publication date: 01-12-2013
Publisher: Springer Milan
Published in: Acta Neurologica Belgica / Issue 4/2013
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-013-0194-6

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Clinical features of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in northeast Iran

Abstract

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