Published in:
01-07-2018 | Review
Activating and inhibitory receptors expressed on innate lymphoid cells
Authors:
Sophie Guia, Aurore Fenis, Eric Vivier, Emilie Narni-Mancinelli
Published in:
Seminars in Immunopathology
|
Issue 4/2018
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Abstract
Innate lymphoid cells (ILCs) are innate immune cells located in lymphoid and non-lymphoid tissues. They are particularly abundant at mucosal and barrier surfaces. Three major ILC subsets are present in humans and mice: group 1 ILCs (comprising natural killer (NK) cells and ILC1s), ILC2s, and ILC3s. ILCs are involved in the maintenance of homeostasis and the regulation of immunity. This review focuses on the extensive array of activating and inhibitory receptors expressed by ILCs for communication with other cell types and their environment in health and disease.