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Clinical Rheumatology
Published in: Clinical Rheumatology 1/2017

01-01-2017 | Review Article

Acro-osteolysis

Authors: Anna Botou, Athanasios Bangeas, Ioannis Alexiou, Lazaros I. Sakkas

Published in: Clinical Rheumatology | Issue 1/2017

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Abstract

Acro-osteolysis is an osteolysis of the distal phalanges of the hands and feet and can affect the terminal tuft or the shaft of the distal phalanx (transverse or band acro-osteolysis). It is often associated with distal digital ischemia, digital calcinosis, or severe sensory neuropathy. Acro-osteolysis has been associated with a heterogeneous group of disorders, including occupational activities, infections, rheumatic disorders (systemic sclerosis, psoriatic arthritis), endocrinopathies, genetic disorders, and lysosomal storage disorders. Plain radiography is the gold standard for the detection of acro-osteolysis.
Literature
1.
Freire V, Bazeli R, Elhai M, Campagna R, Pessis É, Avouac J, Allanore Y, Drapé JL, Guérini H (2013) Hand and wrist involvement in systemic sclerosis: US features. Radiology 269(3):824–830PubMedCrossRef
2.
Preston BJ, Jones KL, Grainger RG (1976) Clinical aspects of vinyl chloride disease: acro-osteolysis. Proc R Soc Med 69(4):284–286PubMedPubMedCentral
3.
Zocchetti C, Osculati A, Colosio C (2010) Acroosteolysis in PVC autoclave cleaners: history of an occupational disease. Med Lav 101:91–109PubMed
4.
5.
Bretza J, Goldman JA (1979) Scleroderma simulating vinyl chloride disease. J Occup Med 21(6):436–438PubMed
6.
Delle Monache F, Cresta V, Marzano P, Palazzi C, Olivieri I (2012) Clinical images: transverse acroosteolysis. Arthritis Rheum 64(5):1641PubMedCrossRef
7.
8.
Lehmer LM, Ragsdale BD, Hoffman D, Clark SJ (2012) Surfer’s toe: trauma-induced idiopathic acro-osteolysis in the toes of a 46-year-old surfer: a case report. J Am Podiatr Med Assoc 102(2):165–168PubMedCrossRef
9.
Baran R, Tosti A (1993) Occupational acroosteolysis in a guitar player. Acta Derm Venereol 73(1):64–65PubMed
10.
Avouac J, Guerini H, Wipff J, Assous N, Chevrot A, Kahan A, Allanore Y (2006) Radiological hand involvement in systemic sclerosis. Ann Rheum Dis 65(8):1088–1092PubMedPubMedCentralCrossRef
11.
Park JK, Fava A, Carrino J, Del Grande F, Rosen A, Boin F (2016) Association of acroosteolysis with enhanced osteoclastogenesis and higher blood levels of vascular endothelial growth factor in systemic sclerosis. Arthritis Rheumatol 68(1):201–209PubMedPubMedCentralCrossRef
12.
Avouac J, Mogavero G, Guerini H, Drapé JL, Mathieu A, Kahan A, Allanore Y (2011) Predictive factors of hand radiographic lesions in systemic sclerosis: a prospective study. Ann Rheum Dis 70(4):630–633PubMedCrossRef
13.
Johnstone EM, Hutchinson CE, Vail A, Chevance A, Herrick AL (2012) Acro-osteolysis in systemic sclerosis is associated with digital ischaemia and severe calcinosis. Rheumatology (Oxford) 51:2234–2238CrossRef
14.
La Montagna G, Baruffo A, Tirri R, Buono G, Valentini G (2002) Foot involvement in systemic sclerosis: a longitudinal study of 100 patients. Semin Arthritis Rheum 31(4):248–255PubMedCrossRef
15.
Braun-Moscovici Y, Furst DE, Markovits D, Rozin A, Clements PJ, Nahir AM, Balbir-Gurman A (2008) Vitamin D, parathyroid hormone, and acroosteolysis in systemic sclerosis. J Rheumatol 35(11):2201–2205PubMedCrossRef
16.
Erre GL, Marongiu A, Fenu P, Faedda R, Masala A, Sanna M, Soro G, Tocco A, Piu D, Marotto D, Passiu G (2008) The “sclerodermic hand”: a radiological and clinical study. Joint Bone Spine 75(4):426–431PubMedCrossRef
17.
Koutaissoff S, Vanthuyne M, Smith V, De Langhe E, Depresseux G, Westhovens R, De Keyser F, Malghem J, Houssiau FA (2011) Hand radiological damage in systemic sclerosis: comparison with a control group and clinical and functional correlations. Semin Arthritis Rheum 40(5):455–460PubMedCrossRef
18.
Azevedo VF, Mueller C, Aragao SC (2008) Asymmetric scleroderma in a CVA patient. Clin Rheumatol 27(10):1321–1323PubMedCrossRef
19.
20.
Ammora L, Jones A (1998) Unusual and memorable. Acro-osteolysis of the terminal phalanges. Ann Rheum Dis 57:389PubMedCrossRef
21.
Bocci EB, Biscontini D, Olivieri I, Gerli R (2009) Acro-osteolysis of the big toe in a patient with psoriatic arthritis. J Rheumatol 36(9):2044PubMedCrossRef
22.
Niamane R, Bezza A, El Hassani S, Bensabbath R, Hajjaj-Hassouni N (2005) Value of the radiographic criteria “fingers and toes” in the early diagnosis of psoriatic arthritis. J Radiol 86(3):321–324PubMedCrossRef
23.
24.
Guillén CA, Zea AC (2011) Acroosteolysis in systemic lupus erythematosus. J Clin Rheumatol 17(2):92–93PubMedCrossRef
25.
Modi M, Vats AK, Prabhakar S, Singla V, Mishra S (2007) Acro-osteolysis and mononeuritis multiplex as a presenting symptom of systemic angiitis of Wegener’s type. Indian J Med Sci 61(4):212–215PubMedCrossRef
26.
27.
Romaní J, Puig L, de Miguel G, de Moragas JM (1997) Carpal tunnel syndrome presenting as sclerodactylia, nail dystrophy and acro-osteolysis in a 60-year-old woman. Dermatology 195(2):159–161PubMedCrossRef
28.
Natale M, Spennato P, Bocchetti A, Fratta M, Savarese L, Rotondo M (2005) Ulcerative and mutilating variant of carpal tunnel syndrome. Acta Neurochir 147(8):905–908PubMedCrossRef
29.
Illarramendi X, Jardim MR, Sales AM, Nery JA, Sarno EN (2000) Acro-osteolysis prior to diagnosis of leprosy. Lepr Rev 71(3):382–387PubMed
30.
Scutellari PN, Orzincolo C, Droghetti M, Bedani PL, Tamarozzi R (1983) The hand of the patient under periodic hemodialysis treatment. Comparative radiographic and xeroradiographic aspects. Radiol Med 69(7–8):527–532PubMed
31.
Henriques JC, Castilho JC, Jacobs R, Amorim JB, Rosa RR, Matai CV (2013) Correlation between hand/wrist and panoramic radiographs in severe secondary hyperparathyroidism. Clin Oral Investig 17(6):1611–1617PubMedCrossRef
32.
Gray MJ, van Kogelenberg M, Beddow R, Morgan T, Wordsworth P, Shears DJ, Robertson SP, Hurst JA (2014) A new acro-osteolysis syndrome caused by duplications including PTHLH. J Hum Genet 59(9):484–487PubMedCrossRef
33.
Baer AN, Zahr ZA, Khan S, Polydefkis M (2012) Acroosteolysis in diabetes mellitus. J Rheumatol 39(12):2364–2365PubMedCrossRef
34.
Cheney WD (1965) Acro-osteolysis. Am J Roentgenol Radium Therapy, Nucl Med 94:595–607
35.
Narumi Y, Min BJ, Shimizu K, Kazukawa I, Sameshima K, Nakamura K, Kosho T, Rhee Y, Chung YS, Kim OH, Fukushima Y, Park WY, Nishimura G (2013) Clinical consequences in truncating mutations in exon 34 of NOTCH2: report of six patients with Hajdu–Cheney syndrome and a patient with serpentine fibula polycystic kidney syndrome. Am J Med Genet A 161A(3):518–526PubMedCrossRef
36.
37.
Damian LO, Simon SP, Filipescu I, Bocsa C, Botar-Jid C, Rednic S (2016) Capillaroscopic findings in a case of Hajdu-Cheney syndrome. Osteoporos Int 27(3):1269–1273PubMedCrossRef
38.
Leidig-Bruckner G, Pfeilschifter J, Penning N, Limberg B, Priemel M, Delling G, Ziegler R (1999) Severe osteoporosis in familial Hajdu–Cheney syndrome: progression of acro-osteolysis and osteoporosis during long-term follow-up. J Bone Miner Res 14(12):2036–2041PubMedCrossRef
39.
Palav S, Vernekar J, Pereira S, Desai A (2014) Hajdu-Cheney syndrome: a case report with review of literature. J Radiol Case Rep 8(9):1–8PubMedPubMedCentral
40.
Potti TA, Petty EM, Lesperance MM (2011) A comprehensive review of reported heritable noggin-associated syndromes and proposed clinical utility of one broadly inclusive diagnostic term: NOG-related-symphalangism spectrum disorder (NOG-SSD). Hum Mutat 32(8):877–886PubMedCrossRef
41.
Yuan L, Chen L, Liao RX, Lin YY, Jiang Y, Wang O, Li M, Xing XP, Pang QQ, Jiajue R, Xia WB (2015) A common mutation and a novel mutation in the HPGD gene in nine patients with primary hypertrophic osteoarthropathy. Calcif Tissue Int 97(4):336–342PubMedCrossRef
42.
Okten A, Mungan I, Kalyoncy M, Orbak Z (2007) Two cases of pachydermoperiostosis with discussion of tamoxifen citrate treatment for arthralgia. Clin Rheumatol 26(1):8–11PubMedCrossRef
43.
Johnston JJ, Sanchez-Contreras MY, Keppler-Noreuil KM, Sapp J, Crenshaw M, Finch NA, Cormier-Daire V, Rademakers R, Sybert VP, Biesecker LG (2015) A point mutation in PDGFRB causes autosomal-dominant Penttinen syndrome. Am J Hum Genet 97(3):465–474PubMedPubMedCentralCrossRef
44.
Penttinen M, Niemi KM, Vinkka-Puhakka H, Johansson R, Aula P (1997) New progeroid disorder. Am J Med Genet 69(2):182–187PubMedCrossRef
45.
Zufferey F, Hadj-Rabia S, De Sandre-Giovannoli A et al (2013) Acro-osteolysis, keloid like-lesions, distinctive facial features, and overgrowth: two newly recognized patients with premature aging syndrome, Penttinen type. Am J Med Genet A 161A(7):1786–1791PubMedCrossRef
46.
47.
48.
Linari S, Castaman G (2015) Clinical manifestations and management of Gaucher disease. Clin Cases Miner Bone Metab 12(2):157–164PubMedPubMedCentral
49.
Clarke LA, Hollak CE (2015) The clinical spectrum and pathophysiology of skeletal complications in lysosomal storage disorders. Best Pract Res Clin Endocrinol Metab 29(2):219–235PubMedCrossRef
50.
Metadata
Title
Acro-osteolysis
Authors
Anna Botou
Athanasios Bangeas
Ioannis Alexiou
Lazaros I. Sakkas
Publication date
01-01-2017
Publisher
Springer London
Published in
Clinical Rheumatology / Issue 1/2017
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-016-3459-7

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