Skip to main content
Top
Published in: Intensive Care Medicine 3/2003

01-03-2003 | Editorial

Acinetobacter baumannii: a threat for the ICU?

Authors: Jordi Rello, Emili Diaz

Published in: Intensive Care Medicine | Issue 3/2003

Login to get access

Excerpt

In 1993, Fagon et al. [1] reported that when pneumonia was caused by Pseudomonas aeruginosa or Acinetobacter spp., the related mortality was estimated as high as 40%, with a relative risk of death of 2.50. This report was important by drawing attention to leading nosocomial pathogens and their association with mortality. However, it ignores the fact that the risk factors [2] and virulence factors [3] for both bacteria are completely different. Unfortunately, no matched cohort studies on pneumonia caused by A. baumannii as a single pathogen have been reported to ascertain its mortality. …
Literature
1.
go back to reference Fagon JY, Chastre J, Hance AJ, Montravers P, Novava A, Gibert C (1993) Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay. Am J Med 94:281–288PubMed Fagon JY, Chastre J, Hance AJ, Montravers P, Novava A, Gibert C (1993) Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay. Am J Med 94:281–288PubMed
2.
go back to reference Baraibar J, Correa H, Mariscal D, Gallego M, Valles J, Rello J (1997) Risk Factors for Infection by Acinetobacter Baumannii in intubated Patients With Nosocomial Pneumonia. Chest 112:1050–1054 Baraibar J, Correa H, Mariscal D, Gallego M, Valles J, Rello J (1997) Risk Factors for Infection by Acinetobacter Baumannii in intubated Patients With Nosocomial Pneumonia. Chest 112:1050–1054
3.
go back to reference Hauser AR, Cobb E, Bodi M, Mariscal D, Valles J, Engel JN, Rello J (2002) Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa. Crit Care Med 30:521–528PubMed Hauser AR, Cobb E, Bodi M, Mariscal D, Valles J, Engel JN, Rello J (2002) Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa. Crit Care Med 30:521–528PubMed
4.
go back to reference Kollef MH, Ward S (1998) The influence of mini-BAL cultures on patient outcomes: implications for the antibiotic management of ventilator-associated pneumonia. Chest 113:412–420PubMed Kollef MH, Ward S (1998) The influence of mini-BAL cultures on patient outcomes: implications for the antibiotic management of ventilator-associated pneumonia. Chest 113:412–420PubMed
5.
go back to reference Rello J, Gallego M, Mariscal D, Soñora R, Valles J (1997) The value of routine microbial investigation in ventilator-associated pneumonia. Am J Respir Crit Care Med 156:196–200 Rello J, Gallego M, Mariscal D, Soñora R, Valles J (1997) The value of routine microbial investigation in ventilator-associated pneumonia. Am J Respir Crit Care Med 156:196–200
6.
go back to reference Rahal JJ, Urban C, Horn D, Freeman K, Segal-Maurer S, Maurer J, Mariano N, Marks S, Burns JM, Dominick D, Lim M (1998) Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella. JAMA 280:1233–1237PubMed Rahal JJ, Urban C, Horn D, Freeman K, Segal-Maurer S, Maurer J, Mariano N, Marks S, Burns JM, Dominick D, Lim M (1998) Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella. JAMA 280:1233–1237PubMed
7.
go back to reference Corbella X, Montero A, Pujol M, Dominguez MA, Ayats J, Argerich MJ, Garrigosa F, Ariza J, Gudiol F (2000) Emergence and rapid spread of carbapenem resistance during a large and sustained hospital outbreak of multiresistant Acinetobacter baumannii. J Clin Microbiol 38:4086–4095PubMed Corbella X, Montero A, Pujol M, Dominguez MA, Ayats J, Argerich MJ, Garrigosa F, Ariza J, Gudiol F (2000) Emergence and rapid spread of carbapenem resistance during a large and sustained hospital outbreak of multiresistant Acinetobacter baumannii. J Clin Microbiol 38:4086–4095PubMed
8.
go back to reference Husni RN, Goldstein LS, Arroliga AC, Hall GS, Fatica C, Stoller JK, Gordon SM (1999) Risk factors for an outbreak of multi-drug-resistant Acinetobacter nosocomial pneumonia among intubated patients Chest 115:1378–1382 Husni RN, Goldstein LS, Arroliga AC, Hall GS, Fatica C, Stoller JK, Gordon SM (1999) Risk factors for an outbreak of multi-drug-resistant Acinetobacter nosocomial pneumonia among intubated patients Chest 115:1378–1382
9.
go back to reference Rello J (1999) Acinetobacter baumannii infections in the ICU: customization is the key. Chest 115:1226–1229PubMed Rello J (1999) Acinetobacter baumannii infections in the ICU: customization is the key. Chest 115:1226–1229PubMed
10.
go back to reference Freeman J, Mc Gowan JE Jr (1978) Risk factors for nosocomial infection. J infect Dis 138:811–819PubMed Freeman J, Mc Gowan JE Jr (1978) Risk factors for nosocomial infection. J infect Dis 138:811–819PubMed
11.
go back to reference Blot S, Vandewoude K, Colardyn F (2003) Nosocomial bacteremia involving Acinetobacter baumannii in critically ill patients: a matched cohort study. Intensive Care Med DOI 10.1007/s00134-003-1648-8 Blot S, Vandewoude K, Colardyn F (2003) Nosocomial bacteremia involving Acinetobacter baumannii in critically ill patients: a matched cohort study. Intensive Care Med DOI 10.1007/s00134-003-1648-8
12.
go back to reference Garcia-Garmendia JL, Ortiz-Leyba C, Garnacho-Montero J, Jimenez-Jimenez FJ, Monterrubio-Villar J, Gili-Miner M (1999) Mortality and the increase in length of stay attributable to the acquisition of Acinetobacter in critically ill patients. Crit Care Med 27:1794–1799PubMed Garcia-Garmendia JL, Ortiz-Leyba C, Garnacho-Montero J, Jimenez-Jimenez FJ, Monterrubio-Villar J, Gili-Miner M (1999) Mortality and the increase in length of stay attributable to the acquisition of Acinetobacter in critically ill patients. Crit Care Med 27:1794–1799PubMed
13.
go back to reference Garnacho-Montero J, Ortiz-Leyba C, Jiménez-Jiménez FJ, Barrero-Almodóvar AE, García-Garmendia JL, Bernabeu-Wittel M, Gallego-Lara (2003) Treatment of multiresistant Acinetobacter baumannii ventilator-associated pneumonia with intravenous colistin: a comparison with imipenem susceptible episodes. Clin Infect Dis (in press) Garnacho-Montero J, Ortiz-Leyba C, Jiménez-Jiménez FJ, Barrero-Almodóvar AE, García-Garmendia JL, Bernabeu-Wittel M, Gallego-Lara (2003) Treatment of multiresistant Acinetobacter baumannii ventilator-associated pneumonia with intravenous colistin: a comparison with imipenem susceptible episodes. Clin Infect Dis (in press)
14.
go back to reference Corbella X, Ariza J, Ardanuy C, Vuelta M, Tubau F, Sora M, Pujol M, Gudiol F (1998) Efficacy of sulbactam alone and in association with ampicillin in nosocomial infections due to Acinetobacter baumannii. J Antimicrob Chemother 42:793–802CrossRef Corbella X, Ariza J, Ardanuy C, Vuelta M, Tubau F, Sora M, Pujol M, Gudiol F (1998) Efficacy of sulbactam alone and in association with ampicillin in nosocomial infections due to Acinetobacter baumannii. J Antimicrob Chemother 42:793–802CrossRef
15.
go back to reference Gerner-Smidt P (1987) Endemic occurrence of Acinetobacter calcoaceticus biovar anitratus in an intensive care unit. J Hosp Infect 10:265–272PubMed Gerner-Smidt P (1987) Endemic occurrence of Acinetobacter calcoaceticus biovar anitratus in an intensive care unit. J Hosp Infect 10:265–272PubMed
Metadata
Title
Acinetobacter baumannii: a threat for the ICU?
Authors
Jordi Rello
Emili Diaz
Publication date
01-03-2003
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 3/2003
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-003-1661-y

Other articles of this Issue 3/2003

Intensive Care Medicine 3/2003 Go to the issue