Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Intensive Care Medicine
Published in: Intensive Care Medicine 3/2003

01-03-2003 | Correspondence

Irreversible ischemia of the hand after peripheral administration of tromethamol (THAM)

Authors: Marjolijn N. de Hooge, Bas H. Verhoeven, Willem J. M. J. Rutten, Maarten W. N. Nijsten

Published in: Intensive Care Medicine | Issue 3/2003

Login to get access

Excerpt

Sir: The practice of administering alkaline buffering solutions in severe metabolic acidosis is common [1]. Sodium bicarbonate (NaHCO3) is frequently used for this purpose, although it has three important disadvantages: initially a further decrease in intracellular pH can occur, CO2 is generated, and it carries a significant sodium load. THAM (tris-hydroxymethyl aminomethane, or tromethamol/TRIS) is an alkaline buffer without these disadvantages. THAM's advantages have recently been stressed, although no controlled studies are available [2, 3, 4]. …
Literature
1.
Adrogue HJ, Madias NE (1998) Management of life-threatening acid-base disorders. First of two parts. N Engl J Med 338:26–34CrossRefPubMed
2.
Weber T, Tschernich H, Sitzwohl C, Ullrich R, Germann P, Zimpfer M, Sladen RN, Huemer G (2000) Tromethamine buffer modifies the depressant effect of permissive hypercapnia on myocardial contractility in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 162:1361–1365
3.
Holmdahl MH, Wiklund L, Wetterberg T, Streat S, Wahlander S, Sutin K, Nahas G (2000) The place of THAM in the management of acidemia in clinical practice. Acta Anaesthesiol Scand 44:524–527CrossRefPubMed
4.
Nahas GG, Sutin KM, Fermon C, Streat S, Wiklund L, Wahlander S, Yellin P, Brasch H, Kanchuger M, Capan L, Manne J, Helwig H, Gaab M, Pfenninger E, Wetterberg T, Holmdahl M, Turndorf H (1998) Guidelines for the treatment of acidaemia with THAM. Drugs 55:191–224PubMed
Metadata
Title
Irreversible ischemia of the hand after peripheral administration of tromethamol (THAM)
Authors
Marjolijn N. de Hooge
Bas H. Verhoeven
Willem J. M. J. Rutten
Maarten W. N. Nijsten
Publication date
01-03-2003
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 3/2003
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-003-1638-x

Other articles of this Issue 3/2003

Intensive Care Medicine 3/2003 Go to the issue

Experimental

Hypothermia protects against endotoxin-induced acute lung injury in rats

Brief Reports

Quality control of mechanical ventilation at the patient's home

Original

DCL-Hb for trauma patients with severe hemorrhagic shock: the European "On-Scene" Multicenter Study

Original

The relationship between methodological trial quality and the effects of impregnated central venous catheters

Original

Microalbuminuria does not reflect increased systemic capillary permeability in septic shock

Original

Patient recollection of airway suctioning in the ICU: routine versus a minimally invasive procedure