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Published in: BMC Infectious Diseases 1/2015

Open Access 01-12-2015 | Research article

About the usefulness of contact precautions for carriers of extended-spectrum beta-lactamase-producing Escherichia coli

Authors: Jean-Ralph Zahar, Laurent Poirel, Claire Dupont, Nicolas Fortineau, Xavier Nassif, Patrice Nordmann

Published in: BMC Infectious Diseases | Issue 1/2015

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Abstract

Background

Extended-spectrum β-lactamases producing Escherichia coli (ESBL-E) are increasingly identified in health care facilities. As previously done for the control of methicillin-resistant Staphylococcus aureus, many hospitals have established screening strategies for early identification of patients being carriers of ESBL producers in general and ESBL-E in particular, and have implemented contact precautions (CP) for infected and colonized patients.

Methods

The incidence of ESBL-E has been compared retrospectively between two French university hospitals (A and B) with different infection control policies over a 5-year long period of time (2006–2010).

Results

While hospital A only implemented standard precautions after identification of patients colonized with ESBL-E, hospital B recommended additional CP. During the period of the study, the ESBL-E incidence rate significantly increased in both hospitals, but no significant difference was observed between the two hospitals.

Conclusions

This observational study did not reveal that additional CP measures had a greater impact on the incidence of ESBL-E in hospital settings.
Literature
1.
go back to reference Zahar JR, Lortholary O, Martin C, Potel G, Plésiat P, Nordmann P. Addressing the challenge of extended-spectrum beta-lactamases. Curr Opin Investig Drugs. 2009;10:172–80.PubMed Zahar JR, Lortholary O, Martin C, Potel G, Plésiat P, Nordmann P. Addressing the challenge of extended-spectrum beta-lactamases. Curr Opin Investig Drugs. 2009;10:172–80.PubMed
2.
go back to reference Chen YH, Hsueh PR, Badal RE, Hawser SP, Hoban DJ, Bouchillon SK, et al. Antimicrobial susceptibility profiles of aerobic and facultative Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region according to currently established susceptibility interpretive criteria. J Infect. 2011;62:280–91.CrossRefPubMed Chen YH, Hsueh PR, Badal RE, Hawser SP, Hoban DJ, Bouchillon SK, et al. Antimicrobial susceptibility profiles of aerobic and facultative Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region according to currently established susceptibility interpretive criteria. J Infect. 2011;62:280–91.CrossRefPubMed
3.
go back to reference Gibold L, Robin F, Tan RN, Delmas J, Bonnet R. Four-year epidemiological study of extended-spectrum β-lactamase-producing Enterobacteriaceae in a French teaching hospital. Clin Microbiol Infect. 2014;20:O20–6.CrossRefPubMed Gibold L, Robin F, Tan RN, Delmas J, Bonnet R. Four-year epidemiological study of extended-spectrum β-lactamase-producing Enterobacteriaceae in a French teaching hospital. Clin Microbiol Infect. 2014;20:O20–6.CrossRefPubMed
4.
go back to reference Courpon-Claudinon A, Lefort A, Panhard X, Clermont O, Dornic Q, Fantin B, et al. Bacteraemia caused by third-generation cephalosporin-resistant Escherichia coli in France : prevalence, molecular epidemiology and clinical features. Clin Microbiol Infect. 2011;17:557–65.CrossRefPubMed Courpon-Claudinon A, Lefort A, Panhard X, Clermont O, Dornic Q, Fantin B, et al. Bacteraemia caused by third-generation cephalosporin-resistant Escherichia coli in France : prevalence, molecular epidemiology and clinical features. Clin Microbiol Infect. 2011;17:557–65.CrossRefPubMed
5.
go back to reference Blanco M, Alonso MP, Nicolas-Chanoine MH, Dahbi G, Mora A, Blanco JE, et al. Molecular epidemiology of Escherichia coli producing extended-spectrum ß-lactamases in Lugo (Spain): dissemination of clone O25b:H4-ST131 producing CTX-M-15. J Antimicrob Chemother. 2009;63:1135–41.CrossRefPubMed Blanco M, Alonso MP, Nicolas-Chanoine MH, Dahbi G, Mora A, Blanco JE, et al. Molecular epidemiology of Escherichia coli producing extended-spectrum ß-lactamases in Lugo (Spain): dissemination of clone O25b:H4-ST131 producing CTX-M-15. J Antimicrob Chemother. 2009;63:1135–41.CrossRefPubMed
6.
go back to reference Hebert C, Weber SG. Common approaches to the control of multidrug-resistant organisms other than methicillin-resistant Staphylococcus aureus (MRSA). Infect Dis Clin North Am. 2011;25:181–200.CrossRefPubMed Hebert C, Weber SG. Common approaches to the control of multidrug-resistant organisms other than methicillin-resistant Staphylococcus aureus (MRSA). Infect Dis Clin North Am. 2011;25:181–200.CrossRefPubMed
7.
go back to reference Lucet JC, Decré D, Fichelle A, Joly-Guillou ML, Pernet M, Deblangy C, et al. Control of a prolonged outbreak of extended-spectrum ß-lactamase-producing Enterobacteriaceae in a university hospital. Clin Infect Dis. 1999;29:1411–8.CrossRefPubMed Lucet JC, Decré D, Fichelle A, Joly-Guillou ML, Pernet M, Deblangy C, et al. Control of a prolonged outbreak of extended-spectrum ß-lactamase-producing Enterobacteriaceae in a university hospital. Clin Infect Dis. 1999;29:1411–8.CrossRefPubMed
8.
go back to reference Mendonca N, Leitao J, Manageiro V, Ferreira E, Canica M. Spread of extended-spectrum ß-lactamase CTX-M-producing Escherichia coli clinical isolates in community and nosocomial environments in Portugal. Antimicrob Agents Chemother. 2007;51:1946–55.CrossRefPubMedPubMedCentral Mendonca N, Leitao J, Manageiro V, Ferreira E, Canica M. Spread of extended-spectrum ß-lactamase CTX-M-producing Escherichia coli clinical isolates in community and nosocomial environments in Portugal. Antimicrob Agents Chemother. 2007;51:1946–55.CrossRefPubMedPubMedCentral
9.
go back to reference Leclercq R, Cantón R, Brown DF, Giske CG, Heisig P, MacGowan AP, et al. EUCAST expert rules in antimicrobial susceptibility testing. Clin Microbiol Infect. 2013;19:141–60.CrossRefPubMed Leclercq R, Cantón R, Brown DF, Giske CG, Heisig P, MacGowan AP, et al. EUCAST expert rules in antimicrobial susceptibility testing. Clin Microbiol Infect. 2013;19:141–60.CrossRefPubMed
10.
go back to reference Rodriguez-Villalobos H, Bogaerts P, Berhin C, Bauraing C, Deplano A, Montesinos I, et al. Trends in production of extended-spectrum ß-lactamases among Enterobacteriaceae of clinical interest: results of a nationwide survey in Belgian hospitals. J Antimicrob Chemother. 2011;66:37–47.CrossRefPubMed Rodriguez-Villalobos H, Bogaerts P, Berhin C, Bauraing C, Deplano A, Montesinos I, et al. Trends in production of extended-spectrum ß-lactamases among Enterobacteriaceae of clinical interest: results of a nationwide survey in Belgian hospitals. J Antimicrob Chemother. 2011;66:37–47.CrossRefPubMed
11.
go back to reference Jarlier V, Trystram D, Brun-Buisson C, Fournier S, Carbonne A, Marty L, et al. Curbing methicillin-resistant Staphylococcus aureus in 38 French hospitals through a 15-year institutional control program. Arch Intern Med. 2010;170:552–9.CrossRefPubMed Jarlier V, Trystram D, Brun-Buisson C, Fournier S, Carbonne A, Marty L, et al. Curbing methicillin-resistant Staphylococcus aureus in 38 French hospitals through a 15-year institutional control program. Arch Intern Med. 2010;170:552–9.CrossRefPubMed
12.
go back to reference Aumeran C, Baud O, Lesens O, Delmas J, Souweine B, Traoré O. Successful control of a hospital-wide vancomycin-resistant Enterococcus faecium outbreak in France. Eur J Clin Microbiol Infect Dis. 2008;27:1061–4.CrossRefPubMed Aumeran C, Baud O, Lesens O, Delmas J, Souweine B, Traoré O. Successful control of a hospital-wide vancomycin-resistant Enterococcus faecium outbreak in France. Eur J Clin Microbiol Infect Dis. 2008;27:1061–4.CrossRefPubMed
13.
go back to reference Cepeda JA, Whitehouse T, Cooper B, Hails J, Jones K, Kwaku F, et al. Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive-care units: prospective two-centre study. Lancet. 2005;365:295–304.CrossRefPubMed Cepeda JA, Whitehouse T, Cooper B, Hails J, Jones K, Kwaku F, et al. Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive-care units: prospective two-centre study. Lancet. 2005;365:295–304.CrossRefPubMed
14.
go back to reference Birgy A, Cohen R, Levy C, Bidet P, Courroux C, Benani M, et al. Community faecal carriage of extended-spectrum ß-lactamase-producing Enterobacteriaceae in French children. BMC Infect Dis. 2012;12:315.CrossRefPubMedPubMedCentral Birgy A, Cohen R, Levy C, Bidet P, Courroux C, Benani M, et al. Community faecal carriage of extended-spectrum ß-lactamase-producing Enterobacteriaceae in French children. BMC Infect Dis. 2012;12:315.CrossRefPubMedPubMedCentral
15.
go back to reference Kirkland KB. Taking off the gloves: toward a less dogmatic approach to the use of contact isolation. Clin Infect Dis. 2009;48:766–71.CrossRefPubMed Kirkland KB. Taking off the gloves: toward a less dogmatic approach to the use of contact isolation. Clin Infect Dis. 2009;48:766–71.CrossRefPubMed
16.
go back to reference Kaier K, Frank U, Hagist C, Conrad A, Meyer E. The impact of antimicrobial drug consumption and alcohol-based hand rub use on the emergence and spread of extended-spectrum ß-lactamase-producing strains: a time-series analysis. J Antimicrob Chemother. 2009;63:609–14.CrossRefPubMed Kaier K, Frank U, Hagist C, Conrad A, Meyer E. The impact of antimicrobial drug consumption and alcohol-based hand rub use on the emergence and spread of extended-spectrum ß-lactamase-producing strains: a time-series analysis. J Antimicrob Chemother. 2009;63:609–14.CrossRefPubMed
17.
go back to reference Reddy P, Malczynski M, Obias A, Reiner S, Jin N, Huang J, et al. Screening for extended-spectrum ß-lactamase-producing Enterobacteriaceae among high-risk patients and rates of subsequent bacteremia. Clin Infect Dis. 2007;45:846–52.CrossRefPubMed Reddy P, Malczynski M, Obias A, Reiner S, Jin N, Huang J, et al. Screening for extended-spectrum ß-lactamase-producing Enterobacteriaceae among high-risk patients and rates of subsequent bacteremia. Clin Infect Dis. 2007;45:846–52.CrossRefPubMed
18.
go back to reference Arnan M, Gudiol C, Calatayud L, Liñares J, Dominguez MÁ, Batlle M, et al. Risk factors for, and clinical relevance of faecal extended-spectrum β-lactamase producing Escherichia coli (ESBL-EC) carriage in neutropenic patients with haematological malignancies. Eur J Clin Microbiol Infect Dis. 2011;30:355–60.CrossRefPubMed Arnan M, Gudiol C, Calatayud L, Liñares J, Dominguez MÁ, Batlle M, et al. Risk factors for, and clinical relevance of faecal extended-spectrum β-lactamase producing Escherichia coli (ESBL-EC) carriage in neutropenic patients with haematological malignancies. Eur J Clin Microbiol Infect Dis. 2011;30:355–60.CrossRefPubMed
19.
go back to reference Chang S, Sethi AK, Eckstein BC, Stiefel U, Cadnum JL, Donskey CJ. Skin and environmental contamination with methicillin-resistant Staphylococcus aureus among carriers identified clinically versus through active surveillance. Clin Infect Dis. 2009;48:1423–8.CrossRefPubMed Chang S, Sethi AK, Eckstein BC, Stiefel U, Cadnum JL, Donskey CJ. Skin and environmental contamination with methicillin-resistant Staphylococcus aureus among carriers identified clinically versus through active surveillance. Clin Infect Dis. 2009;48:1423–8.CrossRefPubMed
20.
go back to reference Goddard S, Muller MP. The efficacy of infection control interventions in reducing the incidence of extended-spectrum ß-lactamase-producing Enterobacteriaceae in the nonoutbreak setting: A systematic review. Am J Infect Control. 2011;39;599–601. Goddard S, Muller MP. The efficacy of infection control interventions in reducing the incidence of extended-spectrum ß-lactamase-producing Enterobacteriaceae in the nonoutbreak setting: A systematic review. Am J Infect Control. 2011;39;599–601.
21.
go back to reference Giuffre M, Cipolla D, Bonura C, Geraci DM, Aleo A, Di Noto S, et al. Outbreak of colonizations by extended-spectrum ß-lactamase-producing Escherichia coli sequence type 131 in a neonatal intensive care unit. Italy Antimicrob Resist Infect Control. 2013;2:8.CrossRefPubMed Giuffre M, Cipolla D, Bonura C, Geraci DM, Aleo A, Di Noto S, et al. Outbreak of colonizations by extended-spectrum ß-lactamase-producing Escherichia coli sequence type 131 in a neonatal intensive care unit. Italy Antimicrob Resist Infect Control. 2013;2:8.CrossRefPubMed
22.
go back to reference Willemsen I, Nelson J, Hendriks Y, Mulders A, Verhoeff S, Mulder P, et al. Extensive dissemination of extended spectrum ß-lactamase-producing Enterobacteriaceae in a Dutch nursing home. Infect Control Hosp Epidemiol. 2015;36:394–400.CrossRefPubMed Willemsen I, Nelson J, Hendriks Y, Mulders A, Verhoeff S, Mulder P, et al. Extensive dissemination of extended spectrum ß-lactamase-producing Enterobacteriaceae in a Dutch nursing home. Infect Control Hosp Epidemiol. 2015;36:394–400.CrossRefPubMed
23.
go back to reference Oteo J, Cercenado E, Fernandez-Romero S, Saez D, Padilla B, Zamora E, et al. Extended-spectrum ß-lactamase-producing Escherichia coli as a cause of pediatric infections: report of a neonatal intensive care unit outbreak due to a CTX-M-14-producing strain. Antimicrob Agents Chemother. 2012;56:54–8.CrossRefPubMedPubMedCentral Oteo J, Cercenado E, Fernandez-Romero S, Saez D, Padilla B, Zamora E, et al. Extended-spectrum ß-lactamase-producing Escherichia coli as a cause of pediatric infections: report of a neonatal intensive care unit outbreak due to a CTX-M-14-producing strain. Antimicrob Agents Chemother. 2012;56:54–8.CrossRefPubMedPubMedCentral
24.
go back to reference Karami N, Helldal L, Welinder-Olsson C, Ahren C, Moore ER. Sub-typing of extended-spectrum ß-lactamase-producing isolates from a nosocomial outbreak: application of a 10-loci generic Escherichia coli multi-locus variable number tandem repeat analysis. PloS One. 2013;8:e83030.CrossRefPubMedPubMedCentral Karami N, Helldal L, Welinder-Olsson C, Ahren C, Moore ER. Sub-typing of extended-spectrum ß-lactamase-producing isolates from a nosocomial outbreak: application of a 10-loci generic Escherichia coli multi-locus variable number tandem repeat analysis. PloS One. 2013;8:e83030.CrossRefPubMedPubMedCentral
25.
go back to reference Tschudin-Sutter S, Frei R, Dangel M, Stranden A, Widmer AF. Rate of transmission of extended-spectrum ß-lactamase-producing enterobacteriaceae without contact isolation. Clin Infect Dis. 2012;55:1505–11.CrossRefPubMed Tschudin-Sutter S, Frei R, Dangel M, Stranden A, Widmer AF. Rate of transmission of extended-spectrum ß-lactamase-producing enterobacteriaceae without contact isolation. Clin Infect Dis. 2012;55:1505–11.CrossRefPubMed
26.
Metadata
Title
About the usefulness of contact precautions for carriers of extended-spectrum beta-lactamase-producing Escherichia coli
Authors
Jean-Ralph Zahar
Laurent Poirel
Claire Dupont
Nicolas Fortineau
Xavier Nassif
Patrice Nordmann
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2015
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-015-1244-x

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