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BMC Medical Genetics
Published in: BMC Medical Genetics 1/2014

Open Access 01-12-2014 | Research article

A replication study of GWAS findings in migraine identifies association in a Swedish case–control sample

Authors: Caroline Ran, Lisette Graae, Patrik KE Magnusson, Nancy L Pedersen, Lars Olson, Andrea C Belin

Published in: BMC Medical Genetics | Issue 1/2014

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Abstract

Background

Migraine is a common neurovascular disorder with symptoms including headache of moderate to severe intensity and recurring attacks. There is no cure for migraine today and the pathology is poorly understood. Common forms of migraine have a complex genetic background and heritability has been estimated to be around 50%. Recent genome-wide association studies (GWAS) on European and American migraine cohorts have led to the identification of new genetic risk factors for migraine.

Methods

We performed an association study in a Swedish population based cohort, investigating the frequency of eight single nucleotide polymorphisms (SNPs) recently identified as genetic risk factors for migraine in three GWAS, using available array data (Illumina Omni Express chip). The eight SNPs were rs2651899, rs3790455, rs10166942, rs7640543, rs9349379, rs1835740, rs6478241 and rs11172113. Because information on rs3790455, rs10166942 and rs7640543 was not directly available, we selected SNPs in high Linkage Disequilibrium (LD) with these three SNPs, and replaced them with rs2274316, rs1003540 and rs4075749, respectively.

Results

We were able to replicate the association with rs2651899 and found a trend for association with rs1835740 in our Swedish cohort.

Conclusions

This is the first reported genetic association study of a Swedish migraine case control material. We have thus replicated findings of susceptibility loci for migraine in an independent genetic material, thereby increasing knowledge about genetic risk factors for this common neurological disorder.
Appendix
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Metadata
Title
A replication study of GWAS findings in migraine identifies association in a Swedish case–control sample
Authors
Caroline Ran
Lisette Graae
Patrik KE Magnusson
Nancy L Pedersen
Lars Olson
Andrea C Belin
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Medical Genetics / Issue 1/2014
Electronic ISSN: 1471-2350
DOI
https://doi.org/10.1186/1471-2350-15-38

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