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Surgical Endoscopy

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01-09-2005 | Original article

A poor response to proton pump inhibition is not a contraindication for laparoscopic antireflux surgery for gastro esophageal reflux disease

Authors: P. M. Wilkerson, J. Stratford, L. Jones, J. Sohanpal, M. I. Booth, T. C. B. Dehn

Published in: Surgical Endoscopy | Issue 9/2005

Abstract

Background

We aimed to determine if a poor response to proton pump inhibitors (PPIs) can predict a poor outcome following laparoscopic antireflux surgery (LARS) in our surgically treated population.

Methods

A total of 324 patients undergoing LARS were included in this study. Following standardized assessment, patients recorded the efficacy of their medication on visual analogue scales. Pre- and postoperative symptom scores were recorded, with outcomes measured by modified Visick scores.

Results

There were 233 good responders (>50% relief) and 91 poor responders (<49% relief). Both groups demonstrated a significant decline in postoperative symptom scores. Ninety-four percent of good responders had an excellent or good outcome, compared to 87% of poor responders. Twenty-seven patients reported a fair or poor outcome, despite improved postoperative symptom scores. Fifteen of these patients reported continuing heartburn; five had positive pH tests.

Conclusion

Our results do not support the assumption that a poor response to PPIs equates to a poor outcome after LARS.

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Title: A poor response to proton pump inhibition is not a contraindication for laparoscopic antireflux surgery for gastro esophageal reflux disease
Authors: P. M. Wilkerson
J. Stratford
L. Jones
J. Sohanpal
M. I. Booth
T. C. B. Dehn
Publication date: 01-09-2005
Publisher: Springer-Verlag
Published in: Surgical Endoscopy / Issue 9/2005
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-004-2238-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A poor response to proton pump inhibition is not a contraindication for laparoscopic antireflux surgery for gastro esophageal reflux disease

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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