Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
BMC Cancer
Published in: BMC Cancer 1/2014

Open Access 01-12-2014 | Case report

A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity

Authors: Masataka Matsumoto, Takashi Nakayama, Daiki Inoue, Kazufumi Takamatsu, Ryo Itotani, Manabu Ishitoko, Shinko Suzuki, Minoru Sakuramoto, Yoshiaki Yuba, Osamu Yoshie, Masaya Takemura, Motonari Fukui

Published in: BMC Cancer | Issue 1/2014

Login to get access

Abstract

Background

Lung cancer cells have been reported to produce cytokines, resulting in systemic reactions. There have been few reports showing that these cytokines induced the formation of an inflammatory mass around lung cancers.

Case presentation

We encountered a patient with a pleomorphic carcinoma of the lung. This tumor produced interleukin (IL)-8, granulocyte colony-stimulating factor and IL-6, which in turn recruited inflammatory cells, such as CD8 positive lymphocytes, around the tumor, resulting in a rapidly growing tumor shadow.

Conclusion

18 F-fluoro-deoxy-glucose positron emission tomography, in addition to a conventional radiological approach such as computed tomography, may detect immunological responses around a tumor.
Appendix
Available only for authorised users
Literature
1.
Hidaka D, Koshizuka H, Hiyama J, Nakatsubo S, Ikeda K, Hayashi A, Fujii A, Sawamoto R, Misumi Y, Miyagawa Y: A case of lung cancer producing granulocyte colony-stimulating factor with a significantly high uptake in the bones observed by a FDG-PET scan. Nihon Kokyuki Gakkai Zasshi. 2009, 47 (3): 259-263.PubMed
2.
Sukou N: A case of large cell lung cancer with high level of G-CSF, IL-6, NSE. Haigan. 2000, 40: 796-797.
3.
Miyazawa M: A case of large cell lung cancer producing G-CSF, IL-6. Jpn J Thorac Cardiovasc Surg. 1999, 47: 105-
4.
Umiwatari H: About lung cancer producing Interleukin-6 and Granulocyte-colony stimulating factor at same time. Haigan. 1997, 37: 762-
5.
Sekido Y, Sato M, Usami N, Shigemitsu K, Mori S, Maeda O, Yokoi T, Hasegawa Y, Yoshioka H, Shimokata K: Establishment of a large cell lung cancer cell line (Y-ML-1B) producing granulocyte colony-stimulating factor. Cancer Genet Cytogenet. 2002, 137 (1): 33-42.CrossRefPubMed
6.
Inoue M, Minami M, Fujii Y, Matsuda H, Shirakura R, Kido T: Granulocyte colony-stimulating factor and interleukin-6-producing lung cancer cell line. LCAM. J Surg Oncol. 1997, 64 (4): 347-350.CrossRefPubMed
7.
Katsumata N, Eguchi K, Fukuda M, Yamamoto N, Ohe Y, Oshita F, Tamura T, Shinkai T, Saijo N: Serum levels of cytokines in patients with untreated primary lung cancer. Clin Cancer Res. 1996, 2 (3): 553-559.PubMed
8.
Tsuyuoka R, Takahashi T, Sasaki Y, Taniguchi Y, Fukumoto M, Suzuki A, Nakamura K, Kobayashi S, Kudo T, Nakao K: Colony-stimulating factor-producing tumours: production of granulocyte colony-stimulating factor and interleukin-6 is secondary to interleukin-1 production. Eur J Cancer. 1994, 30A (14): 2130-2136.CrossRefPubMed
9.
Kimura H, Yamaguchi Y, Sun L, Iwagami S, Sugita K: Establishment of large cell lung cancer cell lines secreting hematopoietic factors inducing leukocytosis and thrombocytosis. Jpn J Clin Oncol. 1992, 22 (5): 313-319.PubMed
10.
Matsuguchi T, Okamura S, Kawasaki C, Shimoda K, Omori F, Hayashi S, Kimura N, Niho Y: Constitutive production of granulocyte colony-stimulating factor and interleukin-6 by a human lung cancer cell line, KSNY: gene amplification and increased mRNA stability. Eur J Haematol. 1991, 47 (2): 128-133.CrossRefPubMed
11.
Suzuki A, Takahashi T, Okuno Y, Nakamura K, Tashiro H, Fukumoto M, Konaka Y, Imura H: Analysis of abnormal expression of g-csf gene in a novel tumor cell line (KHC 287) elaborating G-CSF, IL-1 and IL-6 with co-amplification of c-myc and c-ki-ras. Int J Cancer. 1991, 48 (3): 428-433.CrossRefPubMed
12.
Wakimoto N: Granulocyte colony-stimulating factor (G-CSF). Nihon Rinsho. 2010, 68 (Suppl 7): 50-52.PubMed
13.
Nakayama T, Hieshima K, Nagakubo D, Sato E, Nakayama M, Kawa K, Yoshie O: Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virus. J Virol. 2004, 78 (4): 1665-1674.CrossRefPubMedPubMedCentral
14.
Nakayama T, Fujisawa R, Izawa D, Hieshima K, Takada K, Yoshie O: Human B cells immortalized with Epstein-Barr virus upregulate CCR6 and CCR10 and downregulate CXCR4 and CXCR5. J Virol. 2002, 76 (6): 3072-3077.CrossRefPubMedPubMedCentral
15.
Guo Y, Xu F, Lu T, Duan Z, Zhang Z: Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat Rev. 2012, 38 (7): 904-910.CrossRefPubMed
16.
Mabuchi S, Morimoto A, Fujita M, Isohashi K, Kimura T: G-CSF induces focal intense bone marrow FDG uptake mimicking multiple bone metastases from uterine cervical cancer: a case report and review of the literature. Eur J Gynaecol Oncol. 2012, 33 (3): 316-317.PubMed
17.
Inoue M: Analysis and establish of lung cell line producing G-CSF and IL-6, that have autocrine loop promoting cell proliferation. Haigan. 1997, 37 (5): 762-
18.
Travis WD, Colby TV, Corrin B, Shimosato Y, Brambilla E: Histological Typing of Lung and Pleural Tumours. 1999, Geneva: International Histological Classification of Tumours, World Health Organization, 3CrossRef
19.
Murphy PM: Neutrophil receptors for interleukin-8 and related CXC chemokines. Semin Hematol. 1997, 34 (4): 311-318.PubMed
20.
Kasakura S, Kouji M: Cytokines and Chemokines. 2004, Tokyo: Nihon Igakukan, Revised
Metadata
Title
A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity
Authors
Masataka Matsumoto
Takashi Nakayama
Daiki Inoue
Kazufumi Takamatsu
Ryo Itotani
Manabu Ishitoko
Shinko Suzuki
Minoru Sakuramoto
Yoshiaki Yuba
Osamu Yoshie
Masaya Takemura
Motonari Fukui
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2014
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-14-588

Other articles of this Issue 1/2014

BMC Cancer 1/2014 Go to the issue

Research article

Obesity is a significant risk factor for breast cancer in Arab women

Research article

An epidemiological study assessing the prevalence of human papillomavirus types in women in the Kingdom of Bahrain

Research article

Inhibition of Na+/K+-ATPase induces hybrid cell death and enhanced sensitivity to chemotherapy in human glioblastoma cells

Research article

Provision of breast cancer care and survival in Germany – results from a population-based high resolution study from Saarland

Research article

Increase of gap junction activities in SW480 human colorectal cancer cells

Research article

MicroRNA-1246 enhances migration and invasion through CADM1 in hepatocellular carcinoma
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits