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Knee Surgery, Sports Traumatology, Arthroscopy

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01-11-2009 | Knee

A novel injectable hydrogel in combination with a surgical sealant in a rat knee osteochondral defect model

Authors: Natasa D. Miljkovic, Yen-Chih Lin, Mario Cherubino, Danielle Minteer, Kacey G. Marra

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 11/2009

Abstract

Osteochondral defects are frequent, painful, debilitating and expensive to treat, often resulting in poor results. The goal of the present study was to synthesize and characterize a novel biocompatible and biodegradable hydrogel comprised of poly(ethylene glycol), gelatin, and genipin, and examine the hydrogel as an injectable biomaterial in combination with a cyanoacrylate-based surgical sealant for cartilage repair. An osteochondral knee defect was generated in 24 rats, then the hydrogel, with or without a surgical sealant, was injected into the defect and followed for 14 days. The results demonstrated that the hydrogel is biocompatible and biodegradable, and that the cyanoacrylate-based surgical sealant is a relatively safe option for maintaining the hydrogel in the defect. This is the first study describing a cyanoacrylate-based surgical sealant in combination with a polymer hydrogel for cartilage repair.

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Title: A novel injectable hydrogel in combination with a surgical sealant in a rat knee osteochondral defect model
Authors: Natasa D. Miljkovic
Yen-Chih Lin
Mario Cherubino
Danielle Minteer
Kacey G. Marra
Publication date: 01-11-2009
Publisher: Springer-Verlag
Published in: Knee Surgery, Sports Traumatology, Arthroscopy / Issue 11/2009
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI: https://doi.org/10.1007/s00167-009-0881-2

At a glance: The STEP trials

Springer Medicine

A novel injectable hydrogel in combination with a surgical sealant in a rat knee osteochondral defect model

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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