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Diabetologia
Published in: Diabetologia 9/2017

Open Access 01-09-2017 | Review

A new perspective on metformin therapy in type 1 diabetes

Authors: Rachel Livingstone, James G. Boyle, John R. Petrie, on behalf of The REMOVAL Study Team

Published in: Diabetologia | Issue 9/2017

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Abstract

Metformin is quite frequently used off-label in type 1 diabetes to limit insulin dose requirement. Guidelines recommend that it can improve glucose control in those who are overweight and obese but evidence in support of this is limited. Recently-published findings from the REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL) trial suggest that metformin therapy in type 1 diabetes can reduce atherosclerosis progression, weight and LDL-cholesterol levels. This provides a new perspective on metformin therapy in type 1 diabetes and suggests a potential role for reducing the long-term risk of cardiovascular disease.
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Metadata
Title
A new perspective on metformin therapy in type 1 diabetes
Authors
Rachel Livingstone
James G. Boyle
John R. Petrie
on behalf of The REMOVAL Study Team
Publication date
01-09-2017
Publisher
Springer Berlin Heidelberg
Published in
Diabetologia / Issue 9/2017
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-017-4364-6

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