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Open Access 01-12-2009 | Proceedings

A new gene-based association test for genome-wide association studies

Authors: Alfonso Buil, Angel Martinez-Perez, Alexandre Perera-Lluna, Leonor Rib, Pere Caminal, Jose Manuel Soria

Published in: BMC Proceedings | Special Issue 7/2009

Abstract

Genome-wide association studies are widely used today to discover genetic factors that modify the risk of complex diseases. Usually, these methods work in a SNP-by-SNP fashion. We present a gene-based test that can be applied in the context of genome-wide association studies. We compare both strategies, SNP-based and gene-based, in a sample of cases and controls for rheumatoid arthritis.

We obtained different results using each strategy. The SNP-based test found the PTPN22 gene while the gene-based test found the PHF19-TRAF1-C5 region. That suggests that no single strategy performs better than another in all cases and that a certain underlying genetic architecture can be delineated more easily with one strategy rather than with another.

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Title: A new gene-based association test for genome-wide association studies
Authors: Alfonso Buil
Angel Martinez-Perez
Alexandre Perera-Lluna
Leonor Rib
Pere Caminal
Jose Manuel Soria
Publication date: 01-12-2009
Publisher: BioMed Central
Published in: BMC Proceedings / Issue Special Issue 7/2009
Electronic ISSN: 1753-6561
DOI: https://doi.org/10.1186/1753-6561-3-S7-S130

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A new gene-based association test for genome-wide association studies

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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