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Open Access 01-09-2013 | Proceedings

A morphometric tool applied to angiogenesis research based on vessel segmentation

Authors: Maria-Milagro Fernández-Carrobles, Irene Tadeo, Rosa Noguera, Marcial García-Rojo, Oscar Déniz, Jesús Salido, Gloria Bueno

Published in: Diagnostic Pathology | Special Issue 1/2013

Excerpt

It is now widely accepted that tumor growth and metastasis are angiogenesis and lymphangiogenesis-dependent providing novel therapeutic targets in malignant disease [1‐3]. A common feature of the tumor vessels studies is that the investigators focus on microvessel density overlooking other parameters that might be significant, such as the size and shape of the microvessels [4]. In many aspects, tumor vessels are different from normal vessels [5, 6]. Studies have revealed the importance of the size and shape of blood vessels in, for example laryngeal tumors [7]. …

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Reyes-Aldasoro CC, Williams LJ, Akerman S, Kanthou C, Tozer GM: An automatic algorithm for the segmentation and morphological analysis of microvessels in immunostained histological tumour sections. J Microsc. 2011, 242: 262-278. 10.1111/j.1365-2818.2010.03464.x.CrossRefPubMed

Aperio: Angiogenesis applications. [http://tmalab.jhmi.edu/aperiou/userguides/Microvessel.pdf]

Title: A morphometric tool applied to angiogenesis research based on vessel segmentation
Authors: Maria-Milagro Fernández-Carrobles
Irene Tadeo
Rosa Noguera
Marcial García-Rojo
Oscar Déniz
Jesús Salido
Gloria Bueno
Publication date: 01-09-2013
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue Special Issue 1/2013
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/1746-1596-8-S1-S20

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A morphometric tool applied to angiogenesis research based on vessel segmentation

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