Skip to main content
Top
Published in: Diagnostic Pathology 1/2013

Open Access 01-09-2013 | Proceedings

Digital immunohistochemistry: new horizons and practical solutions in breast cancer pathology

Authors: Arvydas Laurinavicius, Justinas Besusparis, Justina Didziapetryte, Gedmante Radziuviene, Raimundas Meskauskas, Aida Laurinaviciene

Published in: Diagnostic Pathology | Special Issue 1/2013

Login to get access

Excerpt

Digital image analysis (DA) brings new opportunities to enhance breast cancer pathology testing by providing tools to read tissue-based visual data in a more precise, accurate, and high-throughput manner compared to traditional evaluation performed by a pathologist. The applications may vary from very practical computer-assisted diagnosis approaches to obtain more reproducible estimates of biomarker expression to more sophisticated efforts to retrieve and aggregate multi-modal and multi-dimensional data providing integrated metamarkers of the disease [1, 2]. …
Literature
1.
go back to reference Krenacs T, Zsakovics I, Diczhazi C, Ficsor L, Varga VS, Molnar B: The potential of digital microscopy in breast pathology. Pathol Oncol Res. 2009, 15: 55-58. 10.1007/s12253-008-9087-z.CrossRefPubMed Krenacs T, Zsakovics I, Diczhazi C, Ficsor L, Varga VS, Molnar B: The potential of digital microscopy in breast pathology. Pathol Oncol Res. 2009, 15: 55-58. 10.1007/s12253-008-9087-z.CrossRefPubMed
2.
go back to reference Madabhushi A, Agner S, Basavanhally A, Doyle S, Lee G: Computer-aided prognosis: predicting patient and disease outcome via quantitative fusion of multi-scale, multi-modal data. Comput Med Imaging Graph. 2011, 35: 506-514. 10.1016/j.compmedimag.2011.01.008.CrossRefPubMed Madabhushi A, Agner S, Basavanhally A, Doyle S, Lee G: Computer-aided prognosis: predicting patient and disease outcome via quantitative fusion of multi-scale, multi-modal data. Comput Med Imaging Graph. 2011, 35: 506-514. 10.1016/j.compmedimag.2011.01.008.CrossRefPubMed
3.
go back to reference Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thurlimann B, Senn HJ: Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol. 2011, 22: 1736-1747. 10.1093/annonc/mdr304.PubMedCentralCrossRefPubMed Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thurlimann B, Senn HJ: Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol. 2011, 22: 1736-1747. 10.1093/annonc/mdr304.PubMedCentralCrossRefPubMed
4.
go back to reference Seol H, Lee HJ, Choi Y, Lee HE, Kim YJ, Kim JH, Kang E, Kim SW, Park SY: Intratumoral heterogeneity of HER2 gene amplification in breast cancer: its clinicopathological significance. Mod Pathol. 2012, 1-11. Seol H, Lee HJ, Choi Y, Lee HE, Kim YJ, Kim JH, Kang E, Kim SW, Park SY: Intratumoral heterogeneity of HER2 gene amplification in breast cancer: its clinicopathological significance. Mod Pathol. 2012, 1-11.
5.
go back to reference Laurinaviciene A, Dasevicius D, Ostapenko V, Jarmalaite S, Lazutka J, Laurinavicius A: Membrane connectivity estimated by digital image analysis of HER2 immunohistochemistry is concordant with visual scoring and fluorescence in situ hybridization results: algorithm evaluation on breast cancer tissue microarrays. Diagn Pathol. 2011, 6: 87-10.1186/1746-1596-6-87.PubMedCentralCrossRefPubMed Laurinaviciene A, Dasevicius D, Ostapenko V, Jarmalaite S, Lazutka J, Laurinavicius A: Membrane connectivity estimated by digital image analysis of HER2 immunohistochemistry is concordant with visual scoring and fluorescence in situ hybridization results: algorithm evaluation on breast cancer tissue microarrays. Diagn Pathol. 2011, 6: 87-10.1186/1746-1596-6-87.PubMedCentralCrossRefPubMed
6.
go back to reference Laurinavicius A, Laurinaviciene A, Ostapenko V, Dasevicius D, Jarmalaite S, Lazutka J: Immunohistochemistry profiles of breast ductal carcinoma: factor analysis of digital image analysis data. Diagn Pathol. 2012, 7: 27-10.1186/1746-1596-7-27.PubMedCentralCrossRefPubMed Laurinavicius A, Laurinaviciene A, Ostapenko V, Dasevicius D, Jarmalaite S, Lazutka J: Immunohistochemistry profiles of breast ductal carcinoma: factor analysis of digital image analysis data. Diagn Pathol. 2012, 7: 27-10.1186/1746-1596-7-27.PubMedCentralCrossRefPubMed
7.
go back to reference Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, Fitzgibbons PL, Francis G, Goldstein NS, Hayes M: American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. Arch Pathol Lab Med. 2010, 134: 907-922.PubMedCentralPubMed Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, Fitzgibbons PL, Francis G, Goldstein NS, Hayes M: American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. Arch Pathol Lab Med. 2010, 134: 907-922.PubMedCentralPubMed
8.
go back to reference Stevens R, Almanaseer I, Gonzalez M, Caglar D, Knudson RA, Ketterling RP, Schrock DS, Seemayer TA, Bridge JA: Analysis of HER2 gene amplification using an automated fluorescence in situ hybridization signal enumeration system. J Mol Diagn. 2007, 9: 144-150. 10.2353/jmoldx.2007.060102.PubMedCentralCrossRefPubMed Stevens R, Almanaseer I, Gonzalez M, Caglar D, Knudson RA, Ketterling RP, Schrock DS, Seemayer TA, Bridge JA: Analysis of HER2 gene amplification using an automated fluorescence in situ hybridization signal enumeration system. J Mol Diagn. 2007, 9: 144-150. 10.2353/jmoldx.2007.060102.PubMedCentralCrossRefPubMed
9.
go back to reference Schunck C, Mohammad E: Automated analysis of FISH-stained HER2/neu samples with Metafer. Methods Mol Biol. 2011, 724: 91-103. 10.1007/978-1-61779-055-3_6.CrossRefPubMed Schunck C, Mohammad E: Automated analysis of FISH-stained HER2/neu samples with Metafer. Methods Mol Biol. 2011, 724: 91-103. 10.1007/978-1-61779-055-3_6.CrossRefPubMed
Metadata
Title
Digital immunohistochemistry: new horizons and practical solutions in breast cancer pathology
Authors
Arvydas Laurinavicius
Justinas Besusparis
Justina Didziapetryte
Gedmante Radziuviene
Raimundas Meskauskas
Aida Laurinaviciene
Publication date
01-09-2013
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue Special Issue 1/2013
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-8-S1-S15

Other articles of this Special Issue 1/2013

Diagnostic Pathology 1/2013 Go to the issue