Published in:
01-06-2017 | Original Contribution
A meta-analysis of efficacy of Morus alba Linn. to improve blood glucose and lipid profile
Published in: European Journal of Nutrition | Issue 4/2017
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Purpose
The previous studies have reported the Morus alba may improve blood glucose and lipid profile. The evidence from these studies is not consistent. This meta-analysis was to evaluate efficacy of products derived from M. alba on blood glucose and lipid levels.
Methods
Literature was reviewed via international database (PubMed, PubMed Central, ScienceDirect, and SciSearch) and Thai databases. Thirteen RCTs with high quality, assessed by Jadad score, were included.
Results
M. alba expressed a significant reduction in postprandial glucose (PPG) at 30 min (MD −1.04, 95 % CI −1.36, −0.73), 60 min (MD −0.87, 95 % CI −1.27, −0.48) and 90 min (MD −0.55, 95 % CI −0.87, −0.22). The difference was not found in the levels of other glycaemic (FBS, HbA1C, or HOMA-IR) and lipidaemic (TC, TG, LDL, or HDL) markers. Serious adverse effects were found neither in the control nor in the group received M. alba.
Conclusion
Products derived from M. alba can effectively contribute to the reduction in PPG levels, but large-scale RCTs would be informative.