Skip to main content
Top
Published in: Journal of Assisted Reproduction and Genetics 7/2008

01-07-2008 | Case Report

A male phenotype (XY) hermaphrodite treated for seminoma, fathered a healthy child by IVF–ICSI technique

Authors: Faheem Zayed, Ibrahim Ghalayini, Ismail Matalka

Published in: Journal of Assisted Reproduction and Genetics | Issue 7/2008

Login to get access

Abstract

Objective

To report a successful delivery of a healthy infant fathered by an infertile 46, XY true hermaphrodite who suffered from a seminoma.

Design

Case report

Setting

IVF unit in University hospital

Patient(s)

Male 41 years (true hermaphrodite), his wife 35 years

Main Outcome Measures

Laboratory, pathology tests and ultrasound tests

Results

The above patient treated and cured from seminoma, the couple had in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) using frozen testicular sperm and had a healthy baby.

Conclusion

This is the first case report of a successful delivery of a healthy infant fathered by an infertile 46, XY true hermaphrodite who suffered from a seminoma. Once treated and cured, the couple had IVF and ICSI using frozen testicular sperm and had a healthy baby.
Literature
2.
go back to reference Blyth B, Duckett JW Jr. Gonadal differentiation: a review of the physiological process and influencing factors based on recent experimental evidence. J Urol 1991;145:689–94.PubMed Blyth B, Duckett JW Jr. Gonadal differentiation: a review of the physiological process and influencing factors based on recent experimental evidence. J Urol 1991;145:689–94.PubMed
5.
go back to reference Malik V, Gupta D, Meenu Gill M, Salvi AL. Seminoma in a male phenotype 46XX true hermaphrodite. Asian J Surg 2007;30(1):85–7.PubMed Malik V, Gupta D, Meenu Gill M, Salvi AL. Seminoma in a male phenotype 46XX true hermaphrodite. Asian J Surg 2007;30(1):85–7.PubMed
7.
go back to reference Inatomi K, Oka S, Nomura Y, Ta N, Tsuhata K, Yoshida T, et al. Two cases of true hermaphrodite. Japn Soc Ob Gyn 1973;25:720. in Japanese. Inatomi K, Oka S, Nomura Y, Ta N, Tsuhata K, Yoshida T, et al. Two cases of true hermaphrodite. Japn Soc Ob Gyn 1973;25:720. in Japanese.
8.
go back to reference Manba S, Adachi T, Narita S, Nakanishi O, Ishihara N. The pregnancy and delivery from true hermaphrodite. Japn Fertil Steril 1971;16:110. in Japanese. Manba S, Adachi T, Narita S, Nakanishi O, Ishihara N. The pregnancy and delivery from true hermaphrodite. Japn Fertil Steril 1971;16:110. in Japanese.
9.
go back to reference Møller H, Skakkebaek NE. Risk of testicular cancer in subfertile men: case–control study. BMJ 1999;318:599. Møller H, Skakkebaek NE. Risk of testicular cancer in subfertile men: case–control study. BMJ 1999;318:599.
13.
go back to reference Carmignani L, Gadda F, Gazzano G, Ragni G, Paffoni A, Rocco F, et al. Testicular sperm extraction in cancerous testicle in patients with azoospermia: a case report. Hum Reprod 2007;22(4):1068–72.PubMedCrossRef Carmignani L, Gadda F, Gazzano G, Ragni G, Paffoni A, Rocco F, et al. Testicular sperm extraction in cancerous testicle in patients with azoospermia: a case report. Hum Reprod 2007;22(4):1068–72.PubMedCrossRef
14.
go back to reference Novero V Jr, Goossens A, Tournaye H, Silber S, Van Steirteghem AC, Devroey P. Seminoma discovered in two males undergoing successful testicular sperm extraction for intracytoplasmic sperm injection. Fertil Steril 1996;65:1051–4.PubMed Novero V Jr, Goossens A, Tournaye H, Silber S, Van Steirteghem AC, Devroey P. Seminoma discovered in two males undergoing successful testicular sperm extraction for intracytoplasmic sperm injection. Fertil Steril 1996;65:1051–4.PubMed
17.
go back to reference Kohn FM, Schroeder P, Weidner W, Montag M, van del Ven H, Schill WB. Testicular sperm extraction in a patient with metachronous bilateral testicular cancer. Hum Reprod 2001;16:2343–6.PubMed Kohn FM, Schroeder P, Weidner W, Montag M, van del Ven H, Schill WB. Testicular sperm extraction in a patient with metachronous bilateral testicular cancer. Hum Reprod 2001;16:2343–6.PubMed
18.
go back to reference Gundy S, Baki M, Bodrogi I, Czeizl A. Persistence of chromosomal aberration in blood lymphocytes of testicular cancer patients. Oncology 1992;49:376–80.PubMedCrossRef Gundy S, Baki M, Bodrogi I, Czeizl A. Persistence of chromosomal aberration in blood lymphocytes of testicular cancer patients. Oncology 1992;49:376–80.PubMedCrossRef
19.
go back to reference Sugawara N, Tokunaga Y, Maeda M, Komaba R, Araki Y. A successful pregnancy outcome using frozen testicular sperm from a chimeric infertile male with a 46, XX/46, XY karyotype: case report. Hum Reprod 2005;20(1):147–8. doi:10.1093/humrep/deh587.PubMedCrossRef Sugawara N, Tokunaga Y, Maeda M, Komaba R, Araki Y. A successful pregnancy outcome using frozen testicular sperm from a chimeric infertile male with a 46, XX/46, XY karyotype: case report. Hum Reprod 2005;20(1):147–8. doi:10.​1093/​humrep/​deh587.PubMedCrossRef
Metadata
Title
A male phenotype (XY) hermaphrodite treated for seminoma, fathered a healthy child by IVF–ICSI technique
Authors
Faheem Zayed
Ibrahim Ghalayini
Ismail Matalka
Publication date
01-07-2008
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 7/2008
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-008-9234-1

Other articles of this Issue 7/2008

Journal of Assisted Reproduction and Genetics 7/2008 Go to the issue