Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Archives of Virology
Published in: Archives of Virology 5/2017

01-05-2017 | Original Article

A highly divergent Puumala virus lineage in southern Poland

Authors: Ulrike M. Rosenfeld, Stephan Drewes, Hanan Sheikh Ali, Edyta T. Sadowska, Magdalena Mikowska, Gerald Heckel, Paweł Koteja, Rainer G. Ulrich

Published in: Archives of Virology | Issue 5/2017

Login to get access

Abstract

Puumala virus (PUUV) represents one of the most important hantaviruses in Central Europe. Phylogenetic analyses of PUUV strains indicate a strong genetic structuring of this hantavirus. Recently, PUUV sequences were identified in the natural reservoir, the bank vole (Myodes glareolus), collected in the northern part of Poland. The objective of this study was to evaluate the presence of PUUV in bank voles from southern Poland. A total of 72 bank voles were trapped in 2009 at six sites in this part of Poland. RT-PCR and IgG-ELISA analyses detected three PUUV positive voles at one trapping site. The PUUV-infected animals were identified by cytochrome b gene analysis to belong to the Carpathian and Eastern evolutionary lineages of bank vole. The novel PUUV S, M and L segment nucleotide sequences showed the closest similarity to sequences of the Russian PUUV lineage from Latvia, but were highly divergent to those previously found in northern Poland, Slovakia and Austria. In conclusion, the detection of a highly divergent PUUV lineage in southern Poland indicates the necessity of further bank vole monitoring in this region allowing rational public health measures to prevent human infections.
Appendix
Available only for authorised users
Literature
1.
Plyusnin A, Beaty BJ, Elliott RM, Goldbach R, Kormelink R, Lundkvist Å, Schmaljohn CS, Tesh RB (2011) Family Bunyaviridae. In: King AMQ, Adams MJ, Carstens EB, Lefkowitz EJ (eds) Virus taxonomy. Ninth report of the International Committee on Taxonomy of Viruses. Elsevier Inc., San Diego, USA, pp 725–741
2.
3.
Schönrich G, Rang A, Lütteke N, Raftery MJ, Charbonnel N, Ulrich RG (2008) Hantavirus-induced immunity in rodent reservoirs and humans. Immunol Rev 225:163–189CrossRefPubMed
4.
Spitzenberger F (1999) Clethrionomys glareolus. In: Mitchell-Jones AJ (ed) The atlas of European mammals. T & AD Poyser LTD, London, pp 212–213
5.
Heyman P, Ceianu CS, Christova I, Tordo N, Beersma M, João Alves M, Lundkvist Å, Hukic M, Papa A, Tenorio A, Zelená H, Essbauer S, Visontai I, Golovljova I, Connell J, Nicoletti L, Van Esbroeck M, Gjeruldsen Dudman S, Aberle SW, Avšič-Županc T, Korukluoglu G, Nowakowska A, Klempa B, Ulrich RG, Bino S, Engler O, Opp M, Vaheri A (2011) A five-year perspective on the situation of haemorrhagic fever with renal syndrome and status of the hantavirus reservoirs in Europe, 2005-2010. Euro Surveill 16(36):977–986
6.
Reil D, Imholt C, Eccard JA, Jacob J (2015) Beech fructification and bank vole population dynamics - combined analyses of promoters of human Puumala Virus infections in Germany. PLoS One 10(7):e0134124CrossRefPubMedPubMedCentral
7.
Ettinger J, Hofmann J, Enders M, Tewald F, Oehme RM, Rosenfeld UM, Ali HS, Schlegel M, Essbauer S, Osterberg A, Jacob J, Reil D, Klempa B, Ulrich RG, Krüger DH (2012) Multiple synchronous outbreaks of Puumala virus, Germany, 2010. Emerg Infect Dis 18(9):1461–1464CrossRefPubMedPubMedCentral
8.
Weber de Melo V, Sheikh Ali H, Freise J, Kühnert D, Essbauer S, Mertens M, Wanka KM, Drewes S, Ulrich RG, Heckel G (2015) Spatiotemporal dynamics of Puumala hantavirus associated with its rodent host, Myodes glareolus. Evol Appl 8(6):545–559CrossRefPubMedPubMedCentral
9.
Sironen T, Plyusnin A (2011) Genetics and Evolution of Hantaviruses. In: Plyusnin A, Elliot RM (eds) Bunyaviridae: molecular and cellular biology. Caister Academic Press, Norfolk, pp 61–94
10.
Ali HS, Drewes S, Weber de Melo V, Schlegel M, Freise J, Groschup MH, Heckel G, Ulrich RG (2015) Complete genome of a Puumala virus strain from Central Europe. Virus Genes 50(2):292–298CrossRefPubMed
11.
Jääskeläinen KM, Kaukinen P, Minskaya ES, Plyusnina A, Vapalahti O, Elliott RM, Weber F, Vaheri A, Plyusnin A (2007) Tula and Puumala hantavirus NSs ORFs are functional and the products inhibit activation of the interferon-beta promoter. J Med Virol 79(10):1527–1536CrossRefPubMed
12.
Schlegel M, Jacob J, Krüger DH, Rang A, Ulrich RG (2014) Hantavirus emergence in rodents, insectivores and bats. In: Johnson N (ed) Role of animals in emerging viral diseases. Academic Press Waltham, MA, pp 235–291CrossRef
13.
Nowakowska A, Heyman P, Knap JP, Burzyński W, Witas M (2009) The first established focus of hantavirus infection in Poland, 2007. Ann Agric Environ Med 16(1):79–85PubMed
14.
Michalski A, Niemcewicz M, Bielawska-Drózd A, Nowakowska A, Gaweł J, Pitucha G, Joniec J, Zielonka K, Marciniak-Niemcewicz A, Kocik J (2014) Surveillance of hantaviruses in Poland: a study of animal reservoirs and human hantavirus disease in Subcarpathia. Vector Borne Zoonotic Dis 14(7):514–522CrossRefPubMedPubMedCentral
15.
Song JW, Baek LJ, Song KJ, Skrok A, Markowski J, Bratosiewicz-Wasik J, Kordek R, Liberski PP, Yanagihara R (2004) Characterization of Tula virus from common voles (Microtus arvalis) in Poland: evidence for geographic-specific phylogenetic clustering. Virus Genes 29(2):239–247CrossRefPubMed
16.
Gu SH, Markowski J, Kang HJ, Hejduk J, Sikorska B, Liberski PP, Yanagihara R (2013) Boginia virus, a newfound hantavirus harbored by the Eurasian water shrew (Neomys fodiens) in Poland. Virol J 10:160CrossRefPubMedPubMedCentral
17.
Gu SH, Hejduk J, Markowski J, Kang HJ, Markowski M, Połatyńska M, Sikorska B, Liberski PP, Yanagihara R (2014) Co-circulation of soricid- and talpid-borne hantaviruses in Poland. Infect Genet Evol 28:296–303CrossRefPubMedPubMedCentral
18.
Ali HS, Drewes S, Sadowska ET, Mikowska M, Groschup MH, Heckel G, Koteja P, Ulrich RG (2014) First molecular evidence for Puumala hantavirus in Poland. Viruses 6(1):340–353CrossRefPubMed
19.
Gut AK, Gut R, Pencuła M, Jarosz MJ (2013) New cases of suspected HFRS (Hantavirus infection) in south-eastern Poland. Ann Agric Environ Med 20(3):544–548PubMed
20.
Mertens M, Kindler E, Emmerich P, Esser J, Wagner-Wiening C, Wölfel R, Petraityte-Burneikiene R, Schmidt-Chanasit J, Zvirbliene A, Groschup MH, Dobler G, Pfeffer M, Heckel G, Ulrich RG, Essbauer SS (2011) Phylogenetic analysis of Puumala virus subtype Bavaria, characterization and diagnostic use of its recombinant nucleocapsid protein. Virus Genes 43(2):177–191CrossRefPubMed
21.
Essbauer S, Schmidt J, Conraths FJ, Friedrich R, Koch J, Hautmann W, Pfeffer M, Wölfel R, Finke J, Dobler G, Ulrich R (2006) A new Puumala hantavirus subtype in rodents associated with an outbreak of Nephropathia epidemica in South-East Germany in 2004. Epidemiol Infect 134(6):1333–1344CrossRefPubMedPubMedCentral
22.
Klempa B, Fichet-Calvet E, Lecompte E, Auste B, Aniskin V, Meisel H, Denys C, Koivogui L, ter Meulen J, Krüger DH (2006) Hantavirus in African wood mouse, Guinea. Emerg Infect Dis 12(5):838–840CrossRefPubMedPubMedCentral
23.
Razzauti M, Plyusnina A, Henttonen H, Plyusnin A (2008) Accumulation of point mutations and reassortment of genomic RNA segments are involved in the microevolution of Puumala hantavirus in a bank vole (Myodes glareolus) population. J Gen Virol 89(Pt 7):1649–1660CrossRefPubMed
24.
Schlegel M, Ali HS, Stieger N, Groschup MH, Wolf R, Ulrich RG (2012) Molecular identification of small mammal species using novel cytochrome B gene-derived degenerated primers. Biochem Genet 50(5–6):440–447CrossRefPubMed
25.
Ronquist F, Teslenko M, van der Mark P, Ayres DL, Darling A, Höhna S, Larget B, Liu L, Suchard MA, Huelsenbeck JP (2012) MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. Syst Biol 61(3):539–542CrossRefPubMedPubMedCentral
26.
Miller MA, Pfeiffer W, Schwartz T (2010) Creating the CIPRES Science gateway for inference of large phylogenetic trees. In: Gateway Computing Environments Workshop (GCE), 2010. New Orleans, pp 1–8
27.
Kotlík P, Deffontaine V, Mascheretti S, Zima J, Michaux JR, Searle JB (2006) A northern glacial refugium for bank voles (Clethrionomys glareolus). Proc Natl Acad Sci USA 103(40):14860–14864CrossRefPubMedPubMedCentral
28.
Deffontaine V, Libois R, Kotlík P, Sommer R, Nieberding C, Paradis E, Searle JB, Michaux JR (2005) Beyond the Mediterranean peninsulas: evidence of central European glacial refugia for a temperate forest mammal species, the bank vole (Clethrionomys glareolus). Mol Ecol 14(6):1727–1739CrossRefPubMed
29.
Wójcik JM, Kawałko A, Marková S, Searle JB, Kotlík P (2010) Phylogeographic signatures of northward post-glacial colonization from high-latitude refugia: a case study of bank voles using museum specimens. J Zool 281(4):249–262
30.
Boratyński Z, Koteja P (2009) The association between body mass, metabolic rates and survival of bank voles. Functional Ecology 23(2):330–339CrossRef
31.
Faber M, Wollny T, Schlegel M, Wanka KM, Thiel J, Frank C, Rimek D, Ulrich RG, Stark K (2013) Puumala virus outbreak in Western Thuringia, Germany, 2010: epidemiology and strain identification. Zoonoses Public Health 60(8):549–554CrossRefPubMed
32.
Drewes S, Ali HS, Saxenhofer M, Rosenfeld UM, Binder F, Cuypers F, Schlegel M, Röhrs S, Heckel G, Ulrich RG (2017) Host-associated absence of human Puumala virus infections in northern and eastern Germany. Emerg Infect Dis 23(1):83–86CrossRefPubMedPubMedCentral
33.
Razzauti M, Plyusnina A, Niemimaa J, Henttonen H, Plyusnin A (2012) Co-circulation of two Puumala hantavirus lineages in Latvia: a Russian lineage described previously and a novel Latvian lineage. J Med Virol 84(2):314–318CrossRefPubMed
34.
Straková P, Jagdmann S, Balčiauskas L, Balčiauskienė L, Drewes S, Ulrich RG (2017) Molecular detection of Puumala virus in bank voles (Myodes glareolus). Lithuania. Emerg Infect Dis 23(1):158–160CrossRefPubMed
35.
Schmidt S, Saxenhofer M, Drewes S, Schlegel M, Wanka KM, Frank R, Klimpel S, von Blanckenhagen F, Maaz D, Herden C, Freise J, Wolf R, Stubbe M, Borkenhagen P, Ansorge H, Eccard JA, Lang J, Jourdain E, Jacob J, Marianneau P, Heckel G, Ulrich RG (2016) High genetic structuring of Tula hantavirus. Arch Virol 161(5):1135–1149CrossRefPubMed
36.
Monroe MC, Morzunov SP, Johnson AM, Bowen MD, Artsob H, Yates T, Peters CJ, Rollin PE, Ksiazek TG, Nichol ST (1999) Genetic diversity and distribution of Peromyscus-borne hantaviruses in North America. Emerg Infect Dis 5(1):75–86CrossRefPubMedPubMedCentral
37.
Plyusnin A, Morzunov SP (2001) Virus evolution and genetic diversity of hantaviruses and their rodent hosts. Curr Top Microbiol Immunol 256:47–75PubMed
38.
Morzunov SP, Rowe JE, Ksiazek TG, Peters CJ, St Jeor SC, Nichol ST (1998) Genetic analysis of the diversity and origin of hantaviruses in Peromyscus leucopus mice in North America. J Virol 72(1):57–64PubMedPubMedCentral
39.
Vaheri A, Strandin T, Hepojoki J, Sironen T, Henttonen H, Mäkelä S, Mustonen J (2013) Uncovering the mysteries of hantavirus infections. Nat Rev Microbiol 11(8):539–550CrossRefPubMed
Metadata
Title
A highly divergent Puumala virus lineage in southern Poland
Authors
Ulrike M. Rosenfeld
Stephan Drewes
Hanan Sheikh Ali
Edyta T. Sadowska
Magdalena Mikowska
Gerald Heckel
Paweł Koteja
Rainer G. Ulrich
Publication date
01-05-2017
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 5/2017
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-016-3200-5

Other articles of this Issue 5/2017

Archives of Virology 5/2017 Go to the issue

Original Article

Comparative genomics of QX-like infectious bronchitis viruses in Korea

Original Article

Genome sequence of bubaline alphaherpesvirus 1 (BuHV1) isolated in Australia in 1972

Annotated Sequence Record

Deinbollia mosaic virus: a novel begomovirus infecting the sapindaceous weed Deinbollia borbonica in Kenya and Tanzania

Annotated Sequence Record

Full-length genome sequence of the tospovirus melon severe mosaic virus

Original Article

Genetic variation and population structure of Cucumber green mottle mosaic virus

Annotated Sequence Record

Complete genome sequence of a novel mitovirus from the phytopathogenic fungus Rhizoctonia oryzae-sativae
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits