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World Journal of Surgical Oncology

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Open Access 01-12-2007 | Case report

A diagnostic dilemma following risk-reducing surgery for BRCA1 mutation – a case report of primary papillary serous carcinoma presenting as sigmoid cancer

Authors: Manish Chand, Patrick J Moore, Andrew D Clarke, Guy F Nash, Tamas Hickisk

Published in: World Journal of Surgical Oncology | Issue 1/2007

Abstract

Background

Women that carry germ-line mutations for BRCA1 or BRCA2 genes are at an increased risk of developing breast, ovarian and peritoneal cancer. Primary peritoneal carcinoma is a rare tumour histologically identical to papillary serous ovarian carcinoma. Risk-reducing surgery in the form of mastectomy and oophorectomy in premenopausal women has been recommended to prevent breast and ovarian cancer occurrence and decrease the risk of developing primary peritoneal cancer.

Case presentation

We present a case report of a woman with a strong family history of breast cancer who underwent risk-reducing surgery in the form of bilateral salpingo-oophorectomy following a mastectomy for a right-sided breast tumour. Following the finding of a BRCA1 mutation, a prophylactic left-sided mastectomy was performed. After remaining well for twenty-seven years, she presented with rectal bleeding and altered bowel habit, and was found to have a secondary cancer of the sigmoid colon. She was finally diagnosed with primary papillary serous carcinoma of the peritoneum (PSCP).

Conclusion

PSCP can present many years after risk-reducing surgery and be difficult to detect. Surveillance remains the best course of management for patients with known BRCA mutations.

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Title: A diagnostic dilemma following risk-reducing surgery for BRCA1 mutation – a case report of primary papillary serous carcinoma presenting as sigmoid cancer
Authors: Manish Chand
Patrick J Moore
Andrew D Clarke
Guy F Nash
Tamas Hickisk
Publication date: 01-12-2007
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2007
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-5-102

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A diagnostic dilemma following risk-reducing surgery for BRCA1 mutation – a case report of primary papillary serous carcinoma presenting as sigmoid cancer

Abstract

Background

Case presentation

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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