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Published in: Malaria Journal 1/2016

Open Access 01-12-2016 | Research

A cross-sectional study of the availability and price of anti-malarial medicines and malaria rapid diagnostic tests in private sector retail drug outlets in rural Western Kenya, 2013

Authors: Urbanus Kioko, Christina Riley, Stephanie Dellicour, Vincent Were, Peter Ouma, Julie Gutman, Simon Kariuki, Ahmeddin Omar, Meghna Desai, Ann M. Buff

Published in: Malaria Journal | Issue 1/2016

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Abstract

Background

Although anti-malarial medicines are free in Kenyan public health facilities, patients often seek treatment from private sector retail drug outlets. In mid-2010, the Affordable Medicines Facility-malaria (AMFm) was introduced to make quality-assured artemisinin-based combination therapy (ACT) accessible and affordable in private and public sectors.

Methods

Private sector retail drug outlets stocking anti-malarial medications within a surveillance area of approximately 220,000 people in a malaria perennial high-transmission area in rural western Kenya were identified via a census in September 2013. A cross-sectional study was conducted in September–October 2013 to determine availability and price of anti-malarial medicines and malaria rapid diagnostic tests (RDTs) in drug outlets. A standardized questionnaire was administered to collect drug outlet and personnel characteristics and availability and price of anti-malarials and RDTs.

Results

Of 181 drug outlets identified, 179 (99 %) participated in the survey. Thirteen percent were registered pharmacies, 25 % informal drug shops, 46 % general shops, 13 % homesteads and 2 % other. One hundred sixty-five (92 %) had at least one ACT type: 162 (91 %) had recommended first-line artemether-lumefantrine (AL), 22 (12 %) had recommended second-line dihydroartemisinin-piperaquine (DHA-PPQ), 85 (48 %) had sulfadoxine-pyrimethamine (SP), 60 (34 %) had any quinine (QN) formulation, and 14 (8 %) had amodiaquine (AQ) monotherapy. The mean price (range) of an adult treatment course for AL was $1.01 ($0.35–4.71); DHA-PPQ was $4.39 ($0.71–7.06); QN tablets were $2.24 ($0.12–4.71); SP was $0.62 ($0.24–2.35); AQ monotherapy was $0.42 ($0.24–1.06). The mean AL price with or without the AMFm logo did not differ significantly ($1.01 and 1.07, respectively; p = 0.45). Only 17 (10 %) drug outlets had RDTs; 149 (84 %) never stocked RDTs. The mean RDT price was $0.92 ($0.24–2.35).

Conclusions

Most outlets never stocked RDTs; therefore, testing prior to treatment was unlikely for customers seeking treatment in the private retail sector. The recommended first-line treatment, AL, was widely available. Although SP and AQ monotherapy are not recommended for treatment, both were less expensive than AL, which might have caused preferential use by customers. Interventions that create community demand for malaria diagnostic testing prior to treatment and that increase RDT availability should be encouraged.
Literature
1.
go back to reference Division of Malaria Control. Kenya annual malaria report 2012/2013. Nairobi: Ministry of Public Health and Sanitation; 2013. Division of Malaria Control. Kenya annual malaria report 2012/2013. Nairobi: Ministry of Public Health and Sanitation; 2013.
2.
go back to reference Hamel MJ, Adazu K, Obor D, Sewe M, Vulule J, Williamson JM, et al. A reversal in reductions of child mortality in western Kenya, 2003–2009. Am J Trop Med Hyg. 2011;85:597–605.CrossRefPubMedPubMedCentral Hamel MJ, Adazu K, Obor D, Sewe M, Vulule J, Williamson JM, et al. A reversal in reductions of child mortality in western Kenya, 2003–2009. Am J Trop Med Hyg. 2011;85:597–605.CrossRefPubMedPubMedCentral
3.
go back to reference WHO. Guidelines for the treatment of malaria. 2nd ed. Geneva: World Health Organization; 2010. WHO. Guidelines for the treatment of malaria. 2nd ed. Geneva: World Health Organization; 2010.
4.
go back to reference Division of Malaria Control. National guidelines for the diagnosis, treatment and prevention of malaria in Kenya. Nairobi: Ministry of Public Health and Sanitation; 2012. Division of Malaria Control. National guidelines for the diagnosis, treatment and prevention of malaria in Kenya. Nairobi: Ministry of Public Health and Sanitation; 2012.
5.
go back to reference Chuma J, Abuya T, Memusi D, Juma E, Akhwale W, Ntwiga J, et al. Reviewing the literature on access to prompt and effective malaria treatment in Kenya: implications for meeting the Abuja targets. Malar J. 2009;8:243.CrossRefPubMedPubMedCentral Chuma J, Abuya T, Memusi D, Juma E, Akhwale W, Ntwiga J, et al. Reviewing the literature on access to prompt and effective malaria treatment in Kenya: implications for meeting the Abuja targets. Malar J. 2009;8:243.CrossRefPubMedPubMedCentral
6.
go back to reference Cohen J, Dupas P, Schaner SG. Price subsidies, diagnostic tests, and targeting of malaria treatment: evidence from a randomized controlled trial. Cambridge: National Bureau of Economic Research; 2012.CrossRef Cohen J, Dupas P, Schaner SG. Price subsidies, diagnostic tests, and targeting of malaria treatment: evidence from a randomized controlled trial. Cambridge: National Bureau of Economic Research; 2012.CrossRef
7.
go back to reference AMFm Independent Evaluation Team. Independent evaluation of phase 1 of the Affordable Medicines Facility–malaria (AMFm), multi-country independent evaluation report: final report. Calverton: ICF International and London School of Hygiene; 2012. AMFm Independent Evaluation Team. Independent evaluation of phase 1 of the Affordable Medicines Facility–malaria (AMFm), multi-country independent evaluation report: final report. Calverton: ICF International and London School of Hygiene; 2012.
8.
go back to reference Davis B, Ladner J, Sams K, Tekinturhan E, de Korte D, Saba J. Artemisinin-based combination therapy availability and use in the private sector of five AMFm phase 1 countries. Malar J. 2013;12:135.CrossRefPubMedPubMedCentral Davis B, Ladner J, Sams K, Tekinturhan E, de Korte D, Saba J. Artemisinin-based combination therapy availability and use in the private sector of five AMFm phase 1 countries. Malar J. 2013;12:135.CrossRefPubMedPubMedCentral
9.
go back to reference Riley CM, Dellicour S, Ouma P, Kioko U, ter Kuile FO, Omar A, et al. Knowledge and adherence to the national guidelines for malaria case management in pregnancy among healthcare providers and drug outlet dispensers in rural, western Kenya. PLoS One. 2016. doi:10.1371/journal.pone.0145616. Riley CM, Dellicour S, Ouma P, Kioko U, ter Kuile FO, Omar A, et al. Knowledge and adherence to the national guidelines for malaria case management in pregnancy among healthcare providers and drug outlet dispensers in rural, western Kenya. PLoS One. 2016. doi:10.​1371/​journal.​pone.​0145616.
10.
go back to reference Odhiambo FO, Laserson KF, Sewe M, Hamel MJ, Feikin DR, Adazu K, et al. Profile: the KEMRI/CDC health and demographic surveillance system—western Kenya. Int J Epidemiol. 2012;4:977–87.CrossRef Odhiambo FO, Laserson KF, Sewe M, Hamel MJ, Feikin DR, Adazu K, et al. Profile: the KEMRI/CDC health and demographic surveillance system—western Kenya. Int J Epidemiol. 2012;4:977–87.CrossRef
11.
go back to reference KNBS. Statistical abstract 2011. Nairobi: Kenya National Bureau of Statistics; 2012. KNBS. Statistical abstract 2011. Nairobi: Kenya National Bureau of Statistics; 2012.
12.
go back to reference Agarwal A, McMorrow M, Onyango P, Otieno K, Odero C, Williamson J, et al. A randomized trial of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated malaria among children in western Kenya. Malar J. 2013;12:254.CrossRefPubMedPubMedCentral Agarwal A, McMorrow M, Onyango P, Otieno K, Odero C, Williamson J, et al. A randomized trial of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated malaria among children in western Kenya. Malar J. 2013;12:254.CrossRefPubMedPubMedCentral
13.
go back to reference Ogutu BR, Onyango KO, Koskei N, Omondi EK, Ongecha JM, Otieno GA. Efficacy and safety of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children aged less than five years: results of an open-label, randomized, single-centre study. Malar J. 2014;13:33.CrossRefPubMedPubMedCentral Ogutu BR, Onyango KO, Koskei N, Omondi EK, Ongecha JM, Otieno GA. Efficacy and safety of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children aged less than five years: results of an open-label, randomized, single-centre study. Malar J. 2014;13:33.CrossRefPubMedPubMedCentral
14.
go back to reference MOH. National guidelines for diagnosis, treatment and prevention of malaria for health workers. Nairobi: Ministry of Health; 2006. MOH. National guidelines for diagnosis, treatment and prevention of malaria for health workers. Nairobi: Ministry of Health; 2006.
15.
go back to reference Zurovac D, Njogu J, Akhwale W, Hamer DH, Larson BA, Snow RW. Effects of revised diagnostic recommendations on malaria treatment practices across age groups in Kenya. Trop Med Int Health. 2008;13:784–7.CrossRefPubMedPubMedCentral Zurovac D, Njogu J, Akhwale W, Hamer DH, Larson BA, Snow RW. Effects of revised diagnostic recommendations on malaria treatment practices across age groups in Kenya. Trop Med Int Health. 2008;13:784–7.CrossRefPubMedPubMedCentral
16.
go back to reference Sridaran S, McClintock SK, Syphard LM, Herman KM, Barnwell JW, Udhayakumar V. Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations. Malar J. 2010;9:247.CrossRefPubMedPubMedCentral Sridaran S, McClintock SK, Syphard LM, Herman KM, Barnwell JW, Udhayakumar V. Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations. Malar J. 2010;9:247.CrossRefPubMedPubMedCentral
17.
go back to reference Njagi P, Makoyo J, Njoki N, Ochako R, Poyer S, Lussiana C, et al. A tale of two providers: differences in fever case management practices and performance among private clinicians and private pharmacy providers on the Kenyan coast. In: Poster presented at 64th Annual Meeting American Society of Tropical Medicine and Hygiene, 25–29 October 2015. Philadelphia: American Society of Tropical Medicine and Hygiene. Njagi P, Makoyo J, Njoki N, Ochako R, Poyer S, Lussiana C, et al. A tale of two providers: differences in fever case management practices and performance among private clinicians and private pharmacy providers on the Kenyan coast. In: Poster presented at 64th Annual Meeting American Society of Tropical Medicine and Hygiene, 25–29 October 2015. Philadelphia: American Society of Tropical Medicine and Hygiene.
18.
19.
go back to reference RBM Partnership. Diagnostic testing in the retail private sector: lessons learned. Report from RBM Case Management Working Group Meeting; 29–30 April 2013. London: Roll Back Malaria Partnership; 2013. RBM Partnership. Diagnostic testing in the retail private sector: lessons learned. Report from RBM Case Management Working Group Meeting; 29–30 April 2013. London: Roll Back Malaria Partnership; 2013.
20.
go back to reference Mbonye A, Magnussen P, Lal S, Hansen SK, Cundill B, Chandler C, Clarke SE. A cluster randomised trial introducing rapid diagnostic tests into registered drug shops in Uganda: impact on appropriate treatment of malaria. PLoS One. 2015. doi:10.1371/journal.pone.0129545. Mbonye A, Magnussen P, Lal S, Hansen SK, Cundill B, Chandler C, Clarke SE. A cluster randomised trial introducing rapid diagnostic tests into registered drug shops in Uganda: impact on appropriate treatment of malaria. PLoS One. 2015. doi:10.​1371/​journal.​pone.​0129545.
21.
22.
go back to reference Ikwuobe JO, Faragher BE, Alawode G, Lalloo DG. The impact of rapid malaria diagnostic tests upon anti-malarial sales in community pharmacies in Gwagwalada, Nigeria. Malar J. 2013;380:12. Ikwuobe JO, Faragher BE, Alawode G, Lalloo DG. The impact of rapid malaria diagnostic tests upon anti-malarial sales in community pharmacies in Gwagwalada, Nigeria. Malar J. 2013;380:12.
23.
go back to reference Machini B, Nyandigisi A, Kigen S, Memusi D, Kimbui R, Mulinga J, et al. Monitoring outpatient malaria case management under the 2010 diagnostic and treatment policy in Kenya: progress 2010–2014. Nairobi: Ministry of Health; 2014. Machini B, Nyandigisi A, Kigen S, Memusi D, Kimbui R, Mulinga J, et al. Monitoring outpatient malaria case management under the 2010 diagnostic and treatment policy in Kenya: progress 2010–2014. Nairobi: Ministry of Health; 2014.
Metadata
Title
A cross-sectional study of the availability and price of anti-malarial medicines and malaria rapid diagnostic tests in private sector retail drug outlets in rural Western Kenya, 2013
Authors
Urbanus Kioko
Christina Riley
Stephanie Dellicour
Vincent Were
Peter Ouma
Julie Gutman
Simon Kariuki
Ahmeddin Omar
Meghna Desai
Ann M. Buff
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2016
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/s12936-016-1404-5

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