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Journal of the International AIDS Society
Published in: Journal of the International AIDS Society 4/2010

Open Access 01-12-2010 | Poster presentation

A comparison of the FDA TLOVR and FDA Snapshot algorithms based on studies evaluating once-daily vs. twice daily lopinavir/ritonavir (LPV/r) regimens

Authors: R Qaqish, J van Wyk, MS King

Published in: Journal of the International AIDS Society | Special Issue 4/2010

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Excerpt

The FDA TLOVR algorithm has been commonly used to assess virologic response to antiretroviral (ARV) regimens. The FDA Snapshot algorithm has been proposed to replace the TLOVR algorithm, as it is simpler and is expected to yield similar results. Multiple studies determined that efficacy of LPV/r dosed once-daily (QD) + nucleoside reverse transcriptase inhibitors (NRTIs) was statistically similar to LPV/r dosed twice-daily (BID) + NRTIs using the FDA TLOVR algorithm. The purpose of the analyses presented here is to compare the TLOVR and Snapshot algorithms in the context of studies evaluating QD vs. BID LPV/r-based regimens. …
Metadata
Title
A comparison of the FDA TLOVR and FDA Snapshot algorithms based on studies evaluating once-daily vs. twice daily lopinavir/ritonavir (LPV/r) regimens
Authors
R Qaqish
J van Wyk
MS King
Publication date
01-12-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1758-2652-13-S4-P58

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Obesity Clinical Trial Summary

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