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Published in: Clinical Journal of Gastroenterology 4/2016

01-08-2016 | Case Report

A case of simultaneous esophageal squamous cell carcinoma and Barrett’s adenocarcinoma

Authors: Tomoo Yamazaki, Yugo Iwaya, Mai Iwaya, Takayuki Watanabe, Ayako Seki, Yasuhide Ochi, Etsuo Hara, Tomohiro Sekiguchi, Noriko Hosaka, Norikazu Arakura, Eiji Tanaka, Osamu Hasebe

Published in: Clinical Journal of Gastroenterology | Issue 4/2016

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Abstract

A 77-year-old male with a long history of alcohol consumption and smoking was admitted for hoarseness and dysphagia. Computed tomography revealed thickening of the middle intrathoracic esophageal wall and multiple mediastinal lymph node swellings. Esophagogastroduodenoscopic examination disclosed an advanced-stage squamous cell carcinoma lesion in the middle intrathoracic esophagus with synchronous early stage Barrett’s adenocarcinoma. The patient underwent endoscopic submucosal dissection for the adenocarcinoma followed by chemoradiation therapy for the squamous cell carcinoma. In spite of their common risk factors, the simultaneous manifestation of esophageal squamous cell carcinoma and Barrett’s adenocarcinoma is extremely rare and requires further study.
Literature
1.
go back to reference Tachimori Y, Ozawa S, Fujishiro M, et al. Comprehensive registry of esophageal cancer in Japan 2006. Esophagus. 2014;11:21–47.CrossRef Tachimori Y, Ozawa S, Fujishiro M, et al. Comprehensive registry of esophageal cancer in Japan 2006. Esophagus. 2014;11:21–47.CrossRef
2.
go back to reference Fujiwara Y, Arakawa T. Epidemiology and clinical characteristics of GERD in the Japanese population. J Gastroenterol. 2009;44:518–34.CrossRefPubMed Fujiwara Y, Arakawa T. Epidemiology and clinical characteristics of GERD in the Japanese population. J Gastroenterol. 2009;44:518–34.CrossRefPubMed
3.
go back to reference Domper Arnal MJ, Ferrández Arenas Á, Lanas Arbeloa Á, et al. Esophageal cancer: risk factors, screening and endoscopic treatment in Western and Eastern countries. World J Gastroenterol. 2015;21(26):7933–43.PubMedPubMedCentral Domper Arnal MJ, Ferrández Arenas Á, Lanas Arbeloa Á, et al. Esophageal cancer: risk factors, screening and endoscopic treatment in Western and Eastern countries. World J Gastroenterol. 2015;21(26):7933–43.PubMedPubMedCentral
4.
go back to reference de Jonge PJ, van Blankenstein M, Grady WM, et al. Barrett’s oesophagus: epidemiology, cancer risk and implications for management. Gut. 2014;63(1):191–202.CrossRefPubMed de Jonge PJ, van Blankenstein M, Grady WM, et al. Barrett’s oesophagus: epidemiology, cancer risk and implications for management. Gut. 2014;63(1):191–202.CrossRefPubMed
5.
go back to reference Sharma P, Dent J, Armstrong D, et al. The development and validation of an endoscopic grading system for Barrett’s esophagus: the Prague C & M criteria. Gastroenterology. 2006;131:1392–9.CrossRefPubMed Sharma P, Dent J, Armstrong D, et al. The development and validation of an endoscopic grading system for Barrett’s esophagus: the Prague C & M criteria. Gastroenterology. 2006;131:1392–9.CrossRefPubMed
6.
go back to reference Yagi K, Nakamura A, Sekine A. Characteristic endoscopic and magnified endoscopic findings in the normal stomach without Helicobacter pylory infection. J Gastroenterol Hepatol. 2002;17:39–45.CrossRefPubMed Yagi K, Nakamura A, Sekine A. Characteristic endoscopic and magnified endoscopic findings in the normal stomach without Helicobacter pylory infection. J Gastroenterol Hepatol. 2002;17:39–45.CrossRefPubMed
7.
go back to reference The Japan Esophageal Society: Japanese Classification of Esophageal Cancer. 10th ed. Tokyo: Kanehara Shuppan; 2008 The Japan Esophageal Society: Japanese Classification of Esophageal Cancer. 10th ed. Tokyo: Kanehara Shuppan; 2008
8.
9.
go back to reference Hongo M, Nagasaki Y, Shoji T. Epidemiology of esophageal cancer: orient to occident. Effects of chronology, geography and ethnicity. J Gastroenterol Hepatol. 2009;24:729–35.CrossRefPubMed Hongo M, Nagasaki Y, Shoji T. Epidemiology of esophageal cancer: orient to occident. Effects of chronology, geography and ethnicity. J Gastroenterol Hepatol. 2009;24:729–35.CrossRefPubMed
10.
go back to reference Ariella M, Rosengard AM, Hamilton SR. Squamous carcinoma of the esophagus in patients with Barrett esophagus. Mod Pathol. 1989;2(1):2–7. Ariella M, Rosengard AM, Hamilton SR. Squamous carcinoma of the esophagus in patients with Barrett esophagus. Mod Pathol. 1989;2(1):2–7.
11.
go back to reference Allan NK, Weitzner S, Scott L, et al. Adenocarcinoma arising in Barrett’s esophagus with synchronous squamous cell carcinoma of the esophagus. South Med J. 1986;79(8):1036–9.CrossRefPubMed Allan NK, Weitzner S, Scott L, et al. Adenocarcinoma arising in Barrett’s esophagus with synchronous squamous cell carcinoma of the esophagus. South Med J. 1986;79(8):1036–9.CrossRefPubMed
12.
go back to reference Sheahan DG, Berman MA. Barrett’s mucosa with multiple carcinomas of the esophagus and oral cavity. J Clin Gastroenterol. 1986;8(1):103–7.CrossRefPubMed Sheahan DG, Berman MA. Barrett’s mucosa with multiple carcinomas of the esophagus and oral cavity. J Clin Gastroenterol. 1986;8(1):103–7.CrossRefPubMed
13.
go back to reference Geramizadeh B, Safari A, Javadi F, et al. Squamous cell carcinoma of the esophagus and adenocarcinoma of gastroesophageal junction, a rare coincidence. Iran Red Crescent Med J. 2011;13(7):507–9.PubMedPubMedCentral Geramizadeh B, Safari A, Javadi F, et al. Squamous cell carcinoma of the esophagus and adenocarcinoma of gastroesophageal junction, a rare coincidence. Iran Red Crescent Med J. 2011;13(7):507–9.PubMedPubMedCentral
14.
go back to reference Dunbar KB, Spechler SJ. The risk of lymph-node metastases in patients with high-grade dysplasia or intramucosal carcinoma in Barrett’s esophagus: a systematic review. Am J Gastroenterol. 2012;107(6):850–62.CrossRefPubMedPubMedCentral Dunbar KB, Spechler SJ. The risk of lymph-node metastases in patients with high-grade dysplasia or intramucosal carcinoma in Barrett’s esophagus: a systematic review. Am J Gastroenterol. 2012;107(6):850–62.CrossRefPubMedPubMedCentral
15.
go back to reference Yokoyama T, Yokoyama A, Kato H, et al. Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men. Cancer epidemiol Biomarker Prev. 2003;12:1227–33. Yokoyama T, Yokoyama A, Kato H, et al. Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men. Cancer epidemiol Biomarker Prev. 2003;12:1227–33.
16.
go back to reference Corley DA, Kubo A, Levin TR, et al. Helicobacter pylori infection and the risk of Barrett’s oesophagus: a community-based study. Gut. 2008;57(6):727–33.CrossRefPubMed Corley DA, Kubo A, Levin TR, et al. Helicobacter pylori infection and the risk of Barrett’s oesophagus: a community-based study. Gut. 2008;57(6):727–33.CrossRefPubMed
17.
go back to reference Bollschweiler E, Schloesser T, Leers J, et al. High prevalence of colonic polyps in white males with esophageal adenocarcinoma. Dis Colon Rectum. 2009;52(2):299–304.CrossRefPubMed Bollschweiler E, Schloesser T, Leers J, et al. High prevalence of colonic polyps in white males with esophageal adenocarcinoma. Dis Colon Rectum. 2009;52(2):299–304.CrossRefPubMed
18.
go back to reference Balasubramanian G, Gupta N, Giacchino M, et al. Cigarette smoking is a modifiable risk factor for Barrett’s oesophagus. United Eur Gastroenterol J. 2013;1(6):430–7.CrossRef Balasubramanian G, Gupta N, Giacchino M, et al. Cigarette smoking is a modifiable risk factor for Barrett’s oesophagus. United Eur Gastroenterol J. 2013;1(6):430–7.CrossRef
19.
go back to reference Toh Y, Oki E, Ohgaki K, et al. Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: molecular mechanisms of carcinogenesis. Int J Clin Oncol. 2010;15(2):135–44.CrossRefPubMed Toh Y, Oki E, Ohgaki K, et al. Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: molecular mechanisms of carcinogenesis. Int J Clin Oncol. 2010;15(2):135–44.CrossRefPubMed
20.
go back to reference Thrift AP, Cook MB, Vaughan TL, et al. Alcohol and the risk of Barrett’s esophagus:a pooled analysis from the International BEACON consortium. Am J Gastroenterol. 2014;109:1586–94.CrossRefPubMedPubMedCentral Thrift AP, Cook MB, Vaughan TL, et al. Alcohol and the risk of Barrett’s esophagus:a pooled analysis from the International BEACON consortium. Am J Gastroenterol. 2014;109:1586–94.CrossRefPubMedPubMedCentral
21.
go back to reference Iijima K, Koike T, Abe Y, et al. Extensive gastric atrophy:an increased risk factor of superficial esophageal squamous cell carcinoma in Japan. Am J Gastroenterol. 2007;102:1603–9.CrossRefPubMed Iijima K, Koike T, Abe Y, et al. Extensive gastric atrophy:an increased risk factor of superficial esophageal squamous cell carcinoma in Japan. Am J Gastroenterol. 2007;102:1603–9.CrossRefPubMed
22.
go back to reference Anderson LA, Murphy SJ, Johnson BT, et al. Relationship between Helicobacter pylory infection and gastric atrophy and the stages of the oesophageal inflammation, metaplasia, adenocarcinoma sequence:results from the FINBAR case–control study. Gut. 2008;57:734–9.CrossRefPubMed Anderson LA, Murphy SJ, Johnson BT, et al. Relationship between Helicobacter pylory infection and gastric atrophy and the stages of the oesophageal inflammation, metaplasia, adenocarcinoma sequence:results from the FINBAR case–control study. Gut. 2008;57:734–9.CrossRefPubMed
Metadata
Title
A case of simultaneous esophageal squamous cell carcinoma and Barrett’s adenocarcinoma
Authors
Tomoo Yamazaki
Yugo Iwaya
Mai Iwaya
Takayuki Watanabe
Ayako Seki
Yasuhide Ochi
Etsuo Hara
Tomohiro Sekiguchi
Noriko Hosaka
Norikazu Arakura
Eiji Tanaka
Osamu Hasebe
Publication date
01-08-2016
Publisher
Springer Japan
Published in
Clinical Journal of Gastroenterology / Issue 4/2016
Print ISSN: 1865-7257
Electronic ISSN: 1865-7265
DOI
https://doi.org/10.1007/s12328-016-0653-8

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