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Clinical Rheumatology
Published in: Clinical Rheumatology 11/2010

01-11-2010 | Case Report

A case of polymyositis and vasculitis induced by ovulation induction therapy with gonadotropin-releasing hormone

Authors: Ivica Lazúrová, Jana Angelovičová, Jana Petríková, Anna Čalfová, Mária Oetterová, Marián Švajdler

Published in: Clinical Rheumatology | Issue 11/2010

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Abstract

Gonadotropin-releasing hormone (GnRH) is the first key hormone of reproduction. GnRH analogs are extensively used in in vitro fertilization and treatment of sex hormone-dependent cancers due to their ability to bring about 'chemical castration'. Recently it has been showed that it also plays an important role in the modulation of the immune system. We report a case of vasculitis and histologically proven severe polymyositis developed 5 days after GnRH administration due to ovulation induction in an infertile patient with no previous history of autoimmune diseases. After treatment with corticosteroids (prednisone, 30 mg daily), aspirin, and pentoxyphyllin in combination with rehabilitation, an amelioration of muscle impairment was observed.
Literature
1.
Jacobson JD (2001) Gonadotropin-releasing hormone: potential role in autoimmunity. Int Immunopharmacol 1(6):1077–1083CrossRefPubMed
2.
Manger K, Widt L, Kalden JR, Manger B (2006) Prevention of gonadal toxicity and preservation of gonadal function and fertility in young women with systemic lupus erythematosus treated by cyclophosphamide: the PREGO-Study. Autoimmun Rev 5(4):269–272CrossRefPubMed
3.
Jacobson JD (2000) Gonadotropin-releasing hormone and G proteins: potential role of autoimmunity. Ann N Y Acad Sci 917:809–818CrossRefPubMed
4.
Tanriverdi F, Silveira LF, MacColl GS, Bouloux PM (2003) The hypothalamic–pituitary–gonadal axis: immune function and autoimmunity. J Endocrinol 176(3):293–304CrossRefPubMed
5.
Batticane N, Morale MC, Gallo F, Farinella Z, Marchetti B (1991) Luteinizing hormone-releasing hormone signaling at the lymphocyte involves stimulation of interleukin-2 receptor expression. Endocrinology 129(1):277–286CrossRefPubMed
6.
Mann DR, Ansari AA, Akinbami MA, Wallen K, Gould KG, McClure HM (1994) Neonatal treatment with luteinizing hormone-releasing hormone analogs alters peripheral lymphocyte subsets and cellular and humorally mediated immune responses in juvenile and adult male monkeys. J Clin Endocrinol Metab 78:292–298CrossRefPubMed
7.
Chen A, Ganor Y, Rahimipour S, Ben-Aroya N, Koch Y, Levite M (2002) The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs. Nat Med 8:1421–1426CrossRefPubMed
8.
Miyagawa S, Shirai T, Shimamoto I, Ichijo M, Ueki H (1994) Worsening of systemic lupus erythematosus-associated thrombocytopenia after administration of gonadotropin-releasing hormone analog. Arthritis Rheum 37(11):1708–1709CrossRefPubMed
9.
Casoli P, Tumiati B, La Sala G (1997) Fatal exacerbation of systemic lupus erythematosus after induction of ovulation. J Rheumatol 24(8):1639–1640PubMed
10.
Amichai B, Grunwald MH, Halevy S (1993) Allergic vasculitis induced by Decapeptyl: confirmation by macrophage migration inhibition factor (MIF) test. Eur J Obstet Gynecol Reprod Biol 30(52):217–218CrossRef
11.
Turk BG, Dereli T, Dereli D, Akalin T (2007) Leuprolide acetate-induced leukocytoclastic vasculitis. Acta Obstet Gynecol Scand 86(7):892–893CrossRefPubMed
12.
Crayton H, Bohlmann T, Sufit R, Graziano FM (1991) Drug-induced polymyositis secondary to leuprolide acetate (Lupron) therapy for prostatic carcinoma. Clin Exp Rheumatol 9(5):525–528PubMed
13.
Olsen NJ (2004) Drug-induced autoimmunity. Best Pract Res Clin Rheumatology 18(5):677–688CrossRef
14.
Weesner GD, Becker BA, Matteri RL (1997) Expression of luteinizing hormone-releasing hormone and its receptor in porcine immune tissues. Life Sci 61:1643–1649CrossRefPubMed
15.
Huong DL, Wechsler B, Vauthier-Brouzes D, Duhaut P, Costedoat N, Lefebvre G, Piette JC (2002) Importance of planning ovulation induction therapy in systemic lupus erythematosus and antiphospholipid syndrome: a single center retrospective study of 21 cases and 114 cycles. Semin Arthritis Rheum 32(3):174–188CrossRefPubMed
16.
McClean G, McCluggage WG (2003) Unusual morphologic features of uterine leiomyomas treated with gonadotropin-releasing hormone agonists: massive lymphoid infiltration and vasculitis. Int J Surg Pathol 11(4):339–344CrossRefPubMed
17.
Ohmori T, Wakamoto R, Lu LM, Okada K, Nose M (2002) Immunohistochemical study of a case of uterine leiomyoma showing massive lymphoid infiltration and localized vasculitis after LH-RH derivant treatment. Histopathology 41(3):276–277PubMed
Metadata
Title
A case of polymyositis and vasculitis induced by ovulation induction therapy with gonadotropin-releasing hormone
Authors
Ivica Lazúrová
Jana Angelovičová
Jana Petríková
Anna Čalfová
Mária Oetterová
Marián Švajdler
Publication date
01-11-2010
Publisher
Springer-Verlag
Published in
Clinical Rheumatology / Issue 11/2010
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-010-1426-2

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