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Open Access 01-12-2015 | Case report

A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis

Authors: Miho Ohta, Masafumi Moriyama, Yuichi Goto, Shintaro Kawano, Akihiko Tanaka, Takashi Maehara, Sachiko Furukawa, Jun-Nosuke Hayashida, Tamotsu Kiyoshima, Mayumi Shimizu, Yojiro Arinobu, Seiji Nakamura

Published in: World Journal of Surgical Oncology | Issue 1/2015

Abstract

Background

IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz’s disease, is characterized by elevated serum IgG4 and infiltration of IgG4-positive plasma cells in glandular tissues. Recently, several studies reported both malignant lymphoma developed on the background of IgG4-associated conditions and IgG4-producing malignant lymphoma (non-IgG4-related disease).

Case presentation

We report on the case of a 70-year-old man who was strongly suspected IgG4-DS because of high serum IgG4 concentration (215 mg/dl) and bilateral swelling of parotid and submandibular glands. Biopsies of cervical lymph node and a portion of submandibular gland were performed. These histopathological findings subsequently confirmed a diagnosis of marginal zone B cell lymphoma.

Conclusion

Differential diagnosis of IgG4-DS is necessary from other disorders, including Sjögren’s syndrome, sarcoidosis, Castleman’s disease, Wegener’s granulomatosis, lymphoma, and cancer. We suggest that biopsy of swollen lesions is important for a definitive diagnosis of IgG4-DS and discuss the mechanism of development in this case.

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Title: A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis
Authors: Miho Ohta
Masafumi Moriyama
Yuichi Goto
Shintaro Kawano
Akihiko Tanaka
Takashi Maehara
Sachiko Furukawa
Jun-Nosuke Hayashida
Tamotsu Kiyoshima
Mayumi Shimizu
Yojiro Arinobu
Seiji Nakamura
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2015
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/s12957-015-0459-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis

Abstract

Background

Case presentation

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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