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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 4/2016

01-08-2016 | Colorectal Cancer

8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis

Authors: Keishi Sugimachi, MD, PhD, Rui Yamaguchi, PhD, Hidetoshi Eguchi, MD, PhD, Masami Ueda, MD, Atsushi Niida, PhD, Shotaro Sakimura, MD, Hidenari Hirata, MD, Ryutaro Uchi, MD, Yoshiaki Shinden, MD, Tomohiro Iguchi, MD, PhD, Kazutoyo Morita, MD, PhD, Ken Yamamoto, MD, PhD, Satoru Miyano, PhD, Masaki Mori, MD, PhD, Yoshihiko Maehara, MD, PhD, Koshi Mimori, MD, PhD

Published in: Annals of Surgical Oncology | Special Issue 4/2016

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Abstract

Background

Here, we explored the genetic interactions between diabetes and oncogenic single-nucleotide polymorphisms (SNPs) that determine colorectal cancer (CRC) morbidity.

Methods

8q24 rs6983267 polymorphism analysis and cDNA microarray were performed in 107 CRCs to identify the genes associated with diabetes and the oncogenic SNP. Then clinical significance of the gene was validated in 132 CRCs. Meta-analysis of microarray data and diabetic comorbidity was performed.

Results

Of genes associated with a minor SNP allele at 8q24, diabetes, and MYC overexpression, apolipoprotein A-IV (ApoA-IV) was associated with oncogenesis and poor prognosis in CRC patients. Patients with high ApoA-IV expression showed significantly poorer prognosis by univariate and multivariate analysis. Meta-analysis revealed lipid metabolism was associated with ApoA-IV-related oncogenesis in diabetic patients.

Conclusions

Changes in lipid metabolism associated with aberrant expression of ApoA-IV were risks for CRC oncogenesis.
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Metadata
Title
8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis
Authors
Keishi Sugimachi, MD, PhD
Rui Yamaguchi, PhD
Hidetoshi Eguchi, MD, PhD
Masami Ueda, MD
Atsushi Niida, PhD
Shotaro Sakimura, MD
Hidenari Hirata, MD
Ryutaro Uchi, MD
Yoshiaki Shinden, MD
Tomohiro Iguchi, MD, PhD
Kazutoyo Morita, MD, PhD
Ken Yamamoto, MD, PhD
Satoru Miyano, PhD
Masaki Mori, MD, PhD
Yoshihiko Maehara, MD, PhD
Koshi Mimori, MD, PhD
Publication date
01-08-2016
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 4/2016
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-016-5374-1

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