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01-02-2014 | Original Article

⁸⁹Sr bremsstrahlung single photon emission computed tomography using a gamma camera for bone metastases

Authors: Seiichiro Ota, Masaki Uno, Masaki Kato, Masanobu Ishiguro, Takahiro Natsume, Kaoru Kikukawa, Masanori Tadokoro, Takashi Ichihara, Hiroshi Toyama

Published in: Annals of Nuclear Medicine | Issue 2/2014

Abstract

Objective

Strontium-89 chloride (⁸⁹Sr) bremsstrahlung single photon emission computed tomography (SPECT) imaging was evaluated for detecting more detailed whole body ⁸⁹Sr distribution.

Methods

⁸⁹Sr bremsstrahlung whole body planar and merged SPECT images were acquired using two-detector SPECT system. Energy window A (100 keV ± 50 %) for planar imaging and energy window A plus adjacent energy window B (300 keV ± 50 %) for SPECT imaging were set on the continuous spectrum. Thirteen patients with multiple bone metastases were evaluated. Bone metastases can be detected with ^99mTc-HMDP whole body planar and merged SPECT images and compared with ⁸⁹Sr bremsstrahlung whole body planar and merged SPECT images. Based on the location of metastatic lesions seen as hot spots on ^99mTc-HMDP images as a reference, the hot spots on ⁸⁹Sr bremsstrahlung images were divided into the same bone parts as ^99mTc-HMDP images (a total of 35 parts in the whole body), and the number of hot spots were counted. We also evaluated the incidence of extra-osseous uptakes in the intestine on ⁸⁹Sr bremsstrahlung whole body planar images.

Results

A total of 195 bone metastatic lesions were detected in both ^99mTc-HMDP whole body planar and merged SPECT images. Detection of hot spot lesions in ⁸⁹Sr merged SPECT images (127 of 195; 66 %) was more frequent than in ⁸⁹Sr whole body planar images (108 of 195; 56 %), based on metastatic bone lesions in ^99mTc-HMDP whole body planar and merged SPECT images. A large intestinal ⁸⁹Sr accumulation was detected in 5 of the 13 patients (38 %).

Conclusions

⁸⁹Sr bremsstrahlung-merged SPECT imaging could be more useful for detailed detection of whole body ⁸⁹Sr distribution than planar imaging. Intestinal ⁸⁹Sr accumulation due to ⁸⁹Sr physiologic excretion was detected in feces for 4 days after tracer injection.

Paes FM, Serafini AN. Systemic metabolic radiopharmaceutical therapy in the treatment of metastatic bone pain. Semin Nucl Med. 2010;40:89–104.PubMedCrossRef

Kuroda I. Effective use of strontium-89 in osseous metastases. Ann Nucl Med. 2012;26:197–206.PubMedCrossRef

Robinson RG, Spicer JA, Preston DF, Wegst AV, Martin NL. Treatment of metastatic bone pain with strontium-89. Int J Rad Appl Instrum B. 1987;14:219–22.PubMedCrossRef

Bodei L, Lam M, Chiesa C, Flux G, Brans B, Chiti A, et al. EANM procedure guideline for treatment of refractory metastatic bone pain. Eur J Nucl Med Mol Imaging. 2008;35:1934–40.PubMedCrossRef

Serafini AN. Therapy of metastatic bone pain. J Nucl Med. 2001;42:895–906.PubMed

Finlay IG, Mason MD, Shelley M. Radioisotopes for the palliation of metastatic bone cancer: a systematic review. Lancet Oncol. 2005;6:392–400.PubMedCrossRef

Lewington VJ. Bone-seeking radionuclides for therapy. J Nucl Med. 2005;46:38S–47S.PubMed

Kan MK. Palliation of bone pain in patients with metastatic cancer using strontium-89 (Metastron). Cancer Nurs. 1995;18:286–91.PubMedCrossRef

Cipriani C, Atzei G, Argirò G, Boemi S, Shukla S, Rossi G, et al. Gamma camera imaging of osseous metastatic lesions by strontium-89 bremsstrahlung. Eur J Nucl Med. 1997;24:1356–61.PubMedCrossRef

10.

Narita H, Uchiyama M, Ooshita T, Hirase K, Makino M, Mori Y, et al. Imaging of strontium-89 uptake with bremsstrahlung using NaI scintillation camera. Kaku Igaku. 1996;33:1207–12 (in Japanese).

11.

Uchiyama M, Narita H, Makino M, Sekine H, Mori Y, Fukumitsu N, et al. Strontium-89 therapy and imaging with bremsstrahlung in bone metastases. Clin Nucl Med. 1997;22:605–9.PubMedCrossRef

12.

Ota S, Toyama H, Uno M, Kato M, Ishiguro M, Natsume T, et al. A trial of ⁸⁹Sr bremsstrahlung SPECT. Kaku Igaku. 2011;48:101–7 (in Japanese).

13.

Blake GM, Zivanovic MA, Lewington VJ. Measurements of the strontium plasma clearance rate in patients receiving ⁸⁹Sr radionuclide therapy. Eur J Nucl Med. 1989;15:780–3.PubMed

14.

Sisson JC, Yanik GA. Theranostics: evolution of the radiopharmaceutical meta-iodobenzylguanidine in endocrine tumors. Semin Nucl Med. 2012;42:171–84.PubMedCrossRef

15.

Baziotis N, Yakoumakis E, Zissimopoulos A, Geronicola-Trapali X, Malamitsi J, Proukakis C. Strontium-89 chloride in the treatment of bone metastases from breast cancer. Oncology. 1998;55:377–81.PubMedCrossRef

16.

Rossleigh MA, Murray IP, Mackey DW, Bargwanna KA, Nayanar VV. Pediatric solid tumors: evaluation by gallium-67 SPECT studies. J Nucl Med. 1990;31:168–72.PubMed

17.

Gelfand MJ, Elgazzar AH, Kriss VM, Masters PR, Golsch GJ. Iodine-123-MIBG SPECT versus planar imaging in children with neural crest tumors. J Nucl Med. 1994;35:1753–7.PubMed

18.

De Maeseneer M, Lenchik L, Everaert H, Marcelis S, Bossuyt A, Osteaux M, et al. Evaluation of lower back pain with bone scintigraphy and SPECT. Radiographics. 1999;19:901–12.PubMedCrossRef

19.

Uematsu T, Yuen S, Yukisawa S, Aramaki T, Morimoto N, Endo M, et al. Comparison of FDG PET and SPECT for detection of bone metastases in breast cancer. Am J Roentgenol. 2005;184:1266–73.CrossRef

20.

Ito S, Kurosawa H, Kasahara H, Teraoka S, Ariga E, Deji S, et al. (90)Y bremsstrahlung emission computed tomography using gamma cameras. Ann Nucl Med. 2009;23:257–67.PubMedCrossRef

21.

Siegel JA. Quantitative bremsstrahlung SPECT imaging: attenuation-corrected activity determination. J Nucl Med. 1994;35:1213–6.PubMed

22.

Mansberg R, Sorensen N, Mansberg V, Van der Wall H. Yttrium 90 Bremsstrahlung SPECT/CT scan demonstrating areas of tracer/tumour uptake. Eur J Nucl Med Mol Imaging. 2007;34:1887.

23.

Minarik D, Sjögreen Gleisner K, Ljungberg M. Evaluation of quantitative (90)Y SPECT based on experimental phantom studies. Phys Med Biol. 2008;53:5689–703.PubMedCrossRef

24.

Cohn SH, Lippencott SW, Gusmano EA, Robertson JS. Comparative kinetics of Ca47 and Sr85 in man. Radiat Res. 1963;19:104–19.PubMedCrossRef

25.

Blake GM, Zivanovic MA, McEwan AJ, Ackery DM. Sr-89 therapy: strontium kinetics in disseminated carcinoma of the prostate. Eur J Nucl Med. 1986;12:447–54.PubMed

Title: 89Sr bremsstrahlung single photon emission computed tomography using a gamma camera for bone metastases
Authors: Seiichiro Ota
Masaki Uno
Masaki Kato
Masanobu Ishiguro
Takahiro Natsume
Kaoru Kikukawa
Masanori Tadokoro
Takashi Ichihara
Hiroshi Toyama
Publication date: 01-02-2014
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 2/2014
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-013-0788-3

At a glance: The STEP trials

Springer Medicine

⁸⁹Sr bremsstrahlung single photon emission computed tomography using a gamma camera for bone metastases

Abstract

Objective

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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