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European Radiology
Published in: European Radiology 4/2005

01-04-2005 | Urogenital

3D proton MR spectroscopic imaging of prostate cancer using a standard spine coil at 1.5 T in clinical routine: a feasibility study

Authors: Matthias P. Lichy, Jörg Pintaske, Raimund Kottke, Jürgen Machann, Aristotelis Anastasiadis, Stefan Roell, Jörg Hennenlotter, Till Diergarten, Fritz Schick, Arnulf Stenzl, Claus D. Claussen, Heinz-Peter Schlemmer

Published in: European Radiology | Issue 4/2005

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Abstract

The objective of this study was to demonstrate the feasibility of 3D proton MR spectroscopic imaging (MRSI) of the prostate using a standard spine instead of a dedicated endorectal coil at 1.5 T. Twenty-eight patients (25 with biopsy proven prostate cancers and three patients with a benign prostate hyperplasia) were examined. MRI and MRSI were conducted with commercial array surface coils at 1.5 T. Ratios of choline (Cho), creatine (Cr) and citrate (Ci) were calculated for tumour, central and peripheral zone retrospectively, based on axial T2 weighed MR images and histology reports. Prostate cancer was characterized by significantly elevated (Cho+Cr)/Ci ratio compared with non-tumourous prostate tissue. The quality of all proton MR spectra was considered to be good or acceptable in 17/28 patients (61%) and poor in 11/28 (39%) examinations. In 20/25 patients with proven malignancy (80%), MRSI was considered to be helpful for the detection of prostate cancer. In 4/25 patients with proven malignancy (16%) who underwent seed implantation, radiotherapy or hormone deprivation before MR examination spectroscopy was of poor and non-diagnostic quality. MRSI of the prostate is feasible within clinical routine using the spine array surface coil at 1.5 T. It can consequently be applied to patients even with contraindications for endorectal coils. However, spectral quality and signal-to-noise ratio is clearly inferior to 3D MRSI examinations with endorectal coils.
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Metadata
Title
3D proton MR spectroscopic imaging of prostate cancer using a standard spine coil at 1.5 T in clinical routine: a feasibility study
Authors
Matthias P. Lichy
Jörg Pintaske
Raimund Kottke
Jürgen Machann
Aristotelis Anastasiadis
Stefan Roell
Jörg Hennenlotter
Till Diergarten
Fritz Schick
Arnulf Stenzl
Claus D. Claussen
Heinz-Peter Schlemmer
Publication date
01-04-2005
Publisher
Springer-Verlag
Published in
European Radiology / Issue 4/2005
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-004-2547-2

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