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01-03-2014 | Case Report

¹⁸F-DOPA PET/CT for assessment of response to induction chemotherapy in a child with high-risk neuroblastoma

Authors: Arnoldo Piccardo, Egesta Lopci, Luca Foppiani, Giovanni Morana, Massimo Conte

Published in: Pediatric Radiology | Issue 3/2014

Abstract

Functional imaging plays a crucial role in the assessment of neuroblastoma. The evaluation of response to induction chemotherapy is a cornerstone in scheduling proper treatment management in patients affected by high-risk neuroblastoma. ¹²³I-metaiodobenzylguanidine has been recognized as the radiopharmaceutical of choice in neuroblastoma assessment. To date, the clinical role of PET/CT in pediatric malignancy is not well established.¹⁸F-DOPA-PET/CT has been recently used in neuroblastoma, and compared with ¹²³I-MIBG-scan. Scant new data are available about the role of this tool in the evaluation of treatment response after induction chemotherapy. We investigate the role of ¹⁸F-DOPA-PET/CT in characterizing the response to induction chemotherapy in a child affected by high-risk-neuroblastoma, in whom the rare association of ¹²³I-MIBG-negative primary tumor and MIBG-positive bone marrow metastases was observed.

Katzenstein HM, Cohn SL, Shore RM et al (2004) Scintigraphic response by 123I-metaiodobenzylguanidine scan correlates with event-free survival in high-risk neuroblastoma. J Clin Oncol 22:3909–3915PubMedCrossRef

Matthay KK, Shulkin B, Ladenstein R et al (2010) Criteria for evaluation of disease extent by (123) I-metaiodobenzylguanidine scans in neuroblastoma: a report for the International Neuroblastoma Risk Group 16 (INRG) Task Force. Br J Cancer 102:1319–1322PubMedCentralPubMedCrossRef

Papathanasiou ND, Gaze MN, Sullivan K et al (2011) 18F-FDG PET/CT and 123I-metaiodobenzylguanidine imaging in high-risk neuroblastoma: diagnostic comparison and survival analysis. J Nucl Med 52:519–525PubMedCrossRef

Jacobson AF, Deng H, Lombard J et al (2010) 123I-meta-iodobenzylguanidine scintigraphy for the detection of neuroblastoma and pheochromocytoma: results of a meta-analysis. J Clin Endocrinol Metab 95:2596–2606PubMedCrossRef

Matthay KK, Edeline V, Lumbroso J et al (2003) Correlation of early metastatic response by 123I-metaiodobenzylguanidine scintigraphy with overall response and event-free survival in stage IV neuroblastoma. J Clin Oncol 21:2486–2491

Piccardo A, Lopci E, Conte M et al (2012) Comparison of (18)F-dopa PET/CT and (123)I-MIBG scintigraphy in stage 3 and 4 neuroblastoma: a pilot study. Eur J Nucl Med Mol Imaging 39:57–61PubMedCrossRef

Bonnin F, Lumbroso J, Tenenbaum F et al (1994) Refining interpretation of MIBG scans in children. J Nucl Med 35:803–810PubMed

Lu MY, Liu YL, Chang HH et al (2013) Characterization of neuroblastic tumors using 18F-FDOPA PET. J Nucl Med 54:42–49PubMedCrossRef

Title: 18F-DOPA PET/CT for assessment of response to induction chemotherapy in a child with high-risk neuroblastoma
Authors: Arnoldo Piccardo
Egesta Lopci
Luca Foppiani
Giovanni Morana
Massimo Conte
Publication date: 01-03-2014
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Radiology / Issue 3/2014
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-013-2807-x

2024 ASCO Annual Meeting

Springer Medicine

¹⁸F-DOPA PET/CT for assessment of response to induction chemotherapy in a child with high-risk neuroblastoma

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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