Published in:
01-12-2014 | Research Article
11C-choline PET/CT tumor recurrence detection and survival prediction in post-treatment patients with high-grade gliomas
Authors:
Wanhu Li, Li Ma, Xiaoyue Wang, Jujie Sun, Suzhen Wang, Xudong Hu
Published in:
Tumor Biology
|
Issue 12/2014
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Abstract
The aim of the present study is to evaluate the role of 11C-choline positron emission tomography/computed tomography (PET/CT) in detecting tumor recurrence and predicting survival in post-treatment patients with high-grade gliomas. A total of 16 previously treated histopathologically proven high-grade glioma patients were subjected to 11C-choline PET/CT scan and survival analysis. We found that the sensitivity and specificity of 11C-choline PET/CT were 100 and 70 %, whereas those of Gd-MRI were 83.3 and 60 %, respectively. By Cox regression analysis, 11C-choline T/N ratio correlated obviously with overall survival (OS) (hazard ratio = 2.644, 95 % confidence interval [CI] = 1.027–6.807, p = 0.044) independent of Karnofsky performance score. Patients with lower T/N ratio (tumor uptake/normal brain tissue uptake) (≤1.42) had longer survival times than patients with higher T/N ratio (median OS = 15.4 vs. 5.3 months, p < 0.001; progression-free survival (PFS) =4.5 vs. 0.8 months, p = 0.004). Thus, this preliminary study suggests that 11C-choline PET/CT is highly sensitive in detecting tumor recurrence in post-treatment patients with high-grade gliomas. Moreover, our preliminary results suggest that T/N ratio measured by 11C-choline maybe serves as a predictor of patients’ survival with suspected recurrent glioma.