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AIDS and Behavior
Published in: AIDS and Behavior 1/2008

01-07-2008 | Original Paper

100% Adherence Study: Educational Workshops vs. Video Sessions to Improve Adherence Among ART-Naïve Patients in Salvador, Brazil

Authors: Marcia Sampaio-Sa, Kimberly Page-Shafer, David R. Bangsberg, Jennifer Evans, Maria de Lourdes Dourado, Celia Teixeira, Eduardo M. Netto, Carlos Brites

Published in: AIDS and Behavior | Special Issue 1/2008

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Abstract

We conducted a randomized trial to test an intervention aimed at increasing adherence to antiretroviral therapy (ART) among HIV-positive, ART-naïve patients in Salvador, Brazil. Participants (N = 107) were randomized to either educational workshops based on the information-motivation-behavioral skills model (n = 52) or a control video session (n = 55). Changes in self-reported ART adherence, viral load, CD4 cell counts and ART pharmacy records were measured periodically over 12 months. After 3–6 months, ART adherence (≥95%) was 77.8% in the workshop group and 85.7% in video group (as treated) and 53.8% and 65.5%, respectively, using intention-to-treat (ITT) analysis (both P > 0.05) At 9–12 months, ART adherence decreased to 73.7% in the workshop group and 79.1% in the video group (as treated) and 53.8% and 61.8% using ITT, respectively. No differences were found in self-reported adherence, viral load or pharmacy records between groups. We found that the educational workshop intervention does not increase adherence to ART.
Literature
Altice, F. L., & Friedland, G. H. (1998). The era of adherence to HIV therapy. Annals of Internal Medicine, 129, 503–505. Editorial.PubMed
Bangsberg, D. R., Hecht, F. M., Charlebois, E. D., Zolopa, A. R., Holodniy, M., Sheiner, L., et al. (2000). Adherence to protease inhibitors, HIV-1, viral load, and development of drug resistance in an indigent population. AIDS (London, England), 14, 357–366. doi:10.​1097/​00002030-200003100-00008.
Bartlett, J. A. (2002). Addressing the challenges of adherence. Journal of Acquired Immune Deficiency Syndromes, 29(Suppl), S2–S10.PubMed
Bastos, F. I., Kerrigan, D., Malta, M., Carneiro-da-Cunha, C., & Strathdee, A. S. (2001). Treatment for HIV/AIDS in Brazil: Strenghts, challenges, and opportunities for operational research. AIDScience (Science Knowledge Environment). Retrieved September 2, 2007, from http://​www.​aidscience.​com.
Brazilian Ministry of Health. (2001). Implementation and monitoring report—AIDS II—December 1988–May 2001. World Bank Loan BIRD 4392/BR (in Portuguese). Retrieved September 2, 2007 from http://​www.​aids.​gov.​br.
Brazilian Ministry of Health. (2006). Recommendations for antiretroviral therapy in HIV-infected adults and adolescents (in Portuguese). Retrieved September 2, 2007 from http://​www.​aids.​gov.​br.
Brigido, L. F. M., Rodrigues, R., Casseb, J., Oliveira, D., Rossetti, M., Menezes, P., et al. (2001). Impact of adherence to antiretroviral therapy in HIV-1 infected patients at a University Public Service in Brazil. AIDS patient care and STDs, 15(11), 587–593. doi:10.​1089/​1087291017532876​85.
Chesney, M. (2003). Adherence to HAART regimens. AIDS Patient Care and STDs, 17(4), 169–177.
Chesney, M. A., Ickovics, J. R., Chambers, D. B., Gifford, A. L., Neidig, J., Zwickl, B., et al. (2000). Self-reported adherence to anti-retroviral medications among participants in HIV clinical trials: The AACTG adherence instruments. Patient Care Committee & Adherence Working Group of the Outcomes Committee of the Adult AIDS Clinical Trials Group (AACTG). AIDS Care, 12, 255–256. doi:10.​1080/​0954012005004289​1.PubMedCrossRef
Fairley, C. K., Levy, R., Rayner, C. R., Allardice, K., Costello, K., Thomas, C., et al. (2003). Randomized trial of an adherence programme for clients with HIV. International Journal of STD & AIDS, 14, 805–809. doi:10.​1258/​0956462033225561​29.CrossRef
Fisher, W. A., Fisher, J. D., & Harman, J. J. (2003). The information, motivation, behavioral, skills model as a general model of health behavior change: Theoretical approaches to individual-level change. In J Suls & K. A. Wallston (Eds.), Social psychological foundations of health and Illness (pp. 127–153). London: Blackwell.
Hirsch, M. S., Conway, B., D’Aquila, R. T., Johnson, V. A., Brun-Vézinet, F., Clotet, B., et al. (1998). Antiretroviral drug resistance testing in adults with HIV infection: implications for clinical management. Journal of the American Medical Association, 279, 1984–1991. doi:10.​1001/​jama.​279.​24.​1984.PubMedCrossRef
Lyon, M. E., Trexler, C., Akpan-Townsend, C. P. M., Selden, K., Fletcher, J., Addlestone, I. C., et al. (2003). A family group approach to increasing adherence to therapy in HIV-infected youths: Results of a pilot project. AIDS Patient Care and STDs, 1, 299–308. doi:10.​1089/​1087291033221081​75.CrossRef
Mannheimer, S. B., Morse, E., Matts, J. P., Andrews, L., Child, C., Schmetter, B., et al. (2006). Sustained benefit from a long-term antiretroviral adherence intervention. Results from a large randomized clinical trial. Journal of Acquired Immune Deficiency Syndromes, 43, S41–S47. doi:10.​1097/​01.​qai.​0000245887.​58886.​ac.PubMedCrossRef
Marins, J. R. P., Jamal, L. F., Chen, S. Y., Barros, M. B., Hudes, E. S., Barbosa, A. A., et al. (2003). Dramatic improvement in survival among adult Brazilian AIDS patients. AIDS (London, England), 17, 1675–1682. doi:10.​1097/​00002030-200307250-00012.
Murphy, D. A., Lu, M. C., Martin, D., Hoffman, D., & Marelich, W. D. (2002). Results of a pilot intervention trial to improve anti-retroviral adherence among HIV-positive patients. The Journal of the Association of Nurses in AIDS Care, 13, 57–69. doi:10.​1177/​1055329002238026​.PubMedCrossRef
Palella, F. J., Jr., Delaney, K. M., Moorman, A. C., Loveless, M. O., Fuhrer, J., Satten, G. A., et al. (1998). Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV outpatient study investigators. The New England Journal of Medicine, 338(13), 853–860. doi:10.​1056/​NEJM199803263381​301.PubMedCrossRef
Paterson, D. L., Swindells, S., Mohr, J., Brester, M., Vergis, E. N., Squier, C., et al. (2002). Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Annals of Internal Medicine, 133, 21–30.
Perno, C. F., Ceccherini-Silberstein, F., De Luca, A., Cozzi-Lepri, A., Gori, C., Cingolani, A., et al. (2002). Virologic correlates of adherence to antiretroviral medications and therapeutic failure. Journal of Acquired Immune Deficiency Syndromes, 31(3), S118–S122.PubMed
Pinheiro, C. A. T., Leite, J. C. C., Drachler, M. L., & Silveira, V. L. (2002). Factors associated with adherence to antiretroviral therapy in HIV/AIDS patients: A cross-sectional study in Southern Brazil. Brazilian Journal of Medical and Biological Research, 35, 1173–1181.PubMed
Remien, R. H., Stirratt, M. J., Dognin, J., Day, E., El-Bassel, N., & Warne, P. (2006). Moving from theory to research to practice. Implementing an effective dyadic intervention to improve antiretroviral adherence for clinic patients. Journal of Acquired Immune Deficiency Syndromes, 43, S69–S78. doi:10.​1097/​01.​qai.​0000248340.​20685.​7d.PubMedCrossRef
Safren, S. A., Otto, M. W., Worth, J. L., Salomon, E., Johnson, W., Mayer, K., et al. (2001). Two strategies to increase adherence to HIV anti-retroviral medication: Life-steps and medication monitoring. Behaviour Research and Therapy, 39, 1151–1162. doi:10.​1016/​S0005-7967(00)00091-7.PubMedCrossRef
Simoni, J. M., Frick, P. A., Pantalone, D. W., & Turner, B. J. (2003). Antriretroviral adherence interventions: A review of current literature and ongoing studies. Topics in HIV Medicine, 11, 185–198.PubMed
Tesoriero, J., French, T., Weiss, L., Waters, M., Finkelstein, R., & Agins, B. (2003). Stability of adherence to highly active anti-retroviral therapy over time among clients enrolled in the treatment adherence demonstration project. Journal of Acquired Immune Deficiency Syndromes, 33, 484–493.PubMed
Tuldra, A., Fumaz, C. R., Ferrer, M. J., Bayés, R., Arnó, A., Balagué, M., et al. (2000). Prospective randomized two-arm controlled study to determine the efficacy of a specific intervention to improve long-term adherence to highly active anti-retroviral therapy. Journal of Acquired Immune Deficiency Syndromes, 25, 221–228. doi:10.​1097/​00042560-200011010-00003.PubMedCrossRef
Metadata
Title
100% Adherence Study: Educational Workshops vs. Video Sessions to Improve Adherence Among ART-Naïve Patients in Salvador, Brazil
Authors
Marcia Sampaio-Sa
Kimberly Page-Shafer
David R. Bangsberg
Jennifer Evans
Maria de Lourdes Dourado
Celia Teixeira
Eduardo M. Netto
Carlos Brites
Publication date
01-07-2008
Publisher
Springer US
Published in
AIDS and Behavior / Issue Special Issue 1/2008
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-008-9414-0

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