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01-12-2016 | Short Communication

β-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization

Authors: Seth M. Dever, Myosotys Rodriguez, Nazira El-Hage

Published in: Journal of NeuroVirology | Issue 6/2016

Abstract

We previously reported that mRNA expression of the unique alternatively spliced OPRM1 isoform μ-opioid receptor-1K (MOR-1K), which exhibits excitatory cellular signaling, is elevated in HIV-infected individuals with combined neurocognitive impairment (NCI) and HIV encephalitis (HIVE). It has recently been shown that the β₂-adrenergic receptor (β₂-AR) chaperones MOR-1K, normally localized intracellularly, to the cell surface. Here, we found mRNA expression of the adrenoceptor beta 2 (ADRB2) gene is also elevated in NCI-HIVE individuals, as well as that β₂-AR protein expression is elevated in HIV-1-infected primary human astrocytes treated with morphine, and discuss the implications for MOR-1K subcellular localization in this condition.

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Title: β-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization
Authors: Seth M. Dever
Myosotys Rodriguez
Nazira El-Hage
Publication date: 01-12-2016
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 6/2016
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-016-0464-1

At a glance: The STEP trials

Springer Medicine

β-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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