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Sleep and Biological Rhythms
Published in: Sleep and Biological Rhythms 1/2024

05-09-2023 | Zolpidem | Short Paper

Impact of zolpidem and lemborexant on sleep and morning symptoms when used as a single dose for polysomnography

Authors: Hiroyuki Sawatari, Tomoko Yoshikawa, Shin-ichi Ando

Published in: Sleep and Biological Rhythms | Issue 1/2024

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Abstract

This study evaluated the effect of zolpidem and lemborexant on sleep and morning symptoms in patients undergoing type-1 polysomnography for suspected sleep-disordered breathing based on questionnaires and polysomnography results. We enrolled 127 patients (lemborexant: N = 57, zolpidem: N = 25, without hypnotics: N = 45). Rapid eye movement sleep in patients on lemborexant was higher than that in patients without hypnotics (P = 0.02). Frequency of unsteadiness in the morning was higher in patients on zolpidem than that in patients without hypnotics (P = 0.04), which remained after adjustment for potential confounders (P = 0.03). Low-dose lemborexant might be suitable when administered as a single dose during polysomnography.
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Metadata
Title
Impact of zolpidem and lemborexant on sleep and morning symptoms when used as a single dose for polysomnography
Authors
Hiroyuki Sawatari
Tomoko Yoshikawa
Shin-ichi Ando
Publication date
05-09-2023
Publisher
Springer Nature Singapore
Published in
Sleep and Biological Rhythms / Issue 1/2024
Print ISSN: 1446-9235
Electronic ISSN: 1479-8425
DOI
https://doi.org/10.1007/s41105-023-00485-x

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