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Published in: Journal of NeuroVirology 3/2018

01-06-2018 | Short Communication

Zika virus outbreak in New Caledonia and Guillain-Barré syndrome: a case-control study

Authors: Olivier Simon, Blandine Acket, Carole Forfait, Dominique Girault, Ann-Claire Gourinat, Pauline Millon, Maguy Daures, Jessica Vanhomwegen, Segolene Billot, Antoine Biron, Damien Hoinard, Elodie Descloux, David Guyon, Jean Claude Manuguerra, Sylvie Laumond, Nicolas Molko, Myrielle Dupont-Rouzeyrol

Published in: Journal of NeuroVirology | Issue 3/2018

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Abstract

Zika virus (ZIKV) infection has been associated with neurologic disorders including Guillain-Barré syndrome (GBS). In New Caledonia during the ZIKV outbreak (2014–2015), case-control and retrospective studies have been performed to assess the link between ZIKV and GBS. Among the 15 cases included, 33% had evidence of a recent ZIKV infection compared to only 3.3% in the 30 controls involved. All patients were Melanesian, had facial diplegia and similar neurophysiological pattern consistent with acute inflammatory demyelinating polyneuropathy, and recovered well. Furthermore, during the peak of ZIKV transmission, we observed a number of GBS cases higher than the calculated upper limit, emphasizing the fact that ZIKV is now a major trigger of GBS.
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Metadata
Title
Zika virus outbreak in New Caledonia and Guillain-Barré syndrome: a case-control study
Authors
Olivier Simon
Blandine Acket
Carole Forfait
Dominique Girault
Ann-Claire Gourinat
Pauline Millon
Maguy Daures
Jessica Vanhomwegen
Segolene Billot
Antoine Biron
Damien Hoinard
Elodie Descloux
David Guyon
Jean Claude Manuguerra
Sylvie Laumond
Nicolas Molko
Myrielle Dupont-Rouzeyrol
Publication date
01-06-2018
Publisher
Springer International Publishing
Published in
Journal of NeuroVirology / Issue 3/2018
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI
https://doi.org/10.1007/s13365-018-0621-9

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